Journal ArticleDOI
Leishmaniasis: current situation and new perspectives.
TLDR
Research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines, and the newly available control tools should allow a scaling up of control activities in priority areas.Abstract:
Leishmaniasis represents a complex of diseases with an important clinical and epidemiological diversity. Visceral leishmaniasis (VL) is of higher priority than cutaneous leishmaniasis (CL) as it is a fatal disease in the absence of treatment. Anthroponotic VL foci are of special concern as they are at the origin of frequent and deathly epidemics (e.g. Sudan). Leishmaniasis burden remains important: 88 countries, 350 million people at risk, 500,000 new cases of VL per year, 1-1.5 million for CL and DALYs: 2.4 millions. Most of the burden is concentrated on few countries which allows clear geographic priorities. Leishmaniasis is still an important public health problem due to not only environmental risk factors such as massive migrations, urbanisation, deforestation, new irrigation schemes, but also to individual risk factors: HIV, malnutrition, genetic, etc em leader Leishmaniasis is part of those diseases which still requires improved control tools. Consequently WHO/TDR research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines. The ongoing effort has already produced significant results. The newly available control tools should allow a scaling up of control activities in priority areas. In anthroponotic foci, the feasibility of getting a strong impact on mortality, morbidity and transmission, is high.read more
Citations
More filters
Journal ArticleDOI
Leishmaniasis: focus on the design of nanoparticulate vaccine delivery systems
Delaram Doroud,Sima Rafati +1 more
TL;DR: Stability, production reproducibility, low cost per dose and low risk–benefit ratios are desirable characteristics of an ideal vaccine formulation and solid lipid nanoparticles may serve as one of the most promising practical strategies to help to achieve such a leishmanial vaccine, at least in canine species in the developing world.
Journal ArticleDOI
Antileishmanial metabolites from Geosmithia langdonii.
Lourin G. Malak,Mohamed Ali Ibrahim,D. W. Bishay,Afaf M. Abdel-Baky,A. M. Moharram,Babu L. Tekwani,Stephen J. Cutler,Samir A. Ross +7 more
TL;DR: The structures of the isolated metabolites were elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as mass spectrometry for antileishmanial activities.
Journal ArticleDOI
Aspectos epidemiológicos da leishmaniose tegumentar americana em Varzelândia, Minas Gerais, Brasil
Adriana Guimarães Nunes,Edvá Vieira de Paula,Roberto Teodoro,Aluízio Prata,Mario León Silva-Vergara +4 more
TL;DR: The epidemiological characteristics observed in this location are suggestive of an endemic area with old colonization, aiming to test a candidate leishmania vaccine, in a rural area of Varzelândia, Minas Gerais, Brazil.
Journal ArticleDOI
Leishmania amazonensis: Characterization of an ouabain-insensitive Na+-ATPase activity
Elmo Eduardo de Almeida-Amaral,Celso Caruso-Neves,Vanessa Maria Pereira Pires,José Roberto Meyer-Fernandes +3 more
TL;DR: Results show that L. amazonensis expresses a P-type, ouabain-insensitive Na+-ATPase that could be involved with the growth of the parasite.
Journal ArticleDOI
Assessment of Interferon-γ Levels and Leishmanin Skin Test Results in Persons Recovered for Leishmaniasis
Mohammad Hossein Alimohammadian,Stephen L. Jones,Haideh Darabi,Farhad Riazi-Rad,Soheila Ajdary,Aliakbar Shabani,Mohammad A. Rezaee,Mehdi Mohebali,Zohreh Hosseini,Farrokh Modabber +9 more
TL;DR: The data indicate that the LST is significantly more sensitive than IFN-γ levels in people who have been cured of cutaneous leishmaniasis than in persons who have be cured of ZVL.
References
More filters
Journal ArticleDOI
The increase in risk factors for leishmaniasis worldwide.
TL;DR: Increasing risk factors are making leishmaniasis a growing public health concern for many countries around the world, and some are related to a specific eco-epidemiological entity, others affect all forms of leish maniasis.
Journal ArticleDOI
Drug resistance in Indian visceral leishmaniasis.
TL;DR: Despite several disadvantages, amphotericin B is the only drug available for use in these areas and should be used as first‐line drug instead of Sbv, and the new oral antileishmanial drug miltefosine is likely to be the first-line drug in future.
Journal ArticleDOI
Rapid accurate field diagnosis of Indian visceral leishmaniasis
TL;DR: In this paper, a prospective study was conducted to assess the diagnostic usefulness of non-invasive testing for antibody to the leishmanial antigen K39 by means of antigen-impregnated nitrocellulose paper strips adapted for use under field conditions.
Journal ArticleDOI
Effect of insecticide-impregnated dog collars on incidence of zoonotic visceral leishmaniasis in Iranian children: a matched-cluster randomised trial.
TL;DR: Community-wide application of deltamethrin-impregnated dog collars not only protects domestic dogs from L infantum infections, but might also reduce the risk of L infantu infection in children.