Journal ArticleDOI
Leishmaniasis: current situation and new perspectives.
TLDR
Research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines, and the newly available control tools should allow a scaling up of control activities in priority areas.Abstract:
Leishmaniasis represents a complex of diseases with an important clinical and epidemiological diversity. Visceral leishmaniasis (VL) is of higher priority than cutaneous leishmaniasis (CL) as it is a fatal disease in the absence of treatment. Anthroponotic VL foci are of special concern as they are at the origin of frequent and deathly epidemics (e.g. Sudan). Leishmaniasis burden remains important: 88 countries, 350 million people at risk, 500,000 new cases of VL per year, 1-1.5 million for CL and DALYs: 2.4 millions. Most of the burden is concentrated on few countries which allows clear geographic priorities. Leishmaniasis is still an important public health problem due to not only environmental risk factors such as massive migrations, urbanisation, deforestation, new irrigation schemes, but also to individual risk factors: HIV, malnutrition, genetic, etc em leader Leishmaniasis is part of those diseases which still requires improved control tools. Consequently WHO/TDR research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines. The ongoing effort has already produced significant results. The newly available control tools should allow a scaling up of control activities in priority areas. In anthroponotic foci, the feasibility of getting a strong impact on mortality, morbidity and transmission, is high.read more
Citations
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Journal ArticleDOI
Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis.
Lucilene Aparecida Resende,Bruno Mendes Roatt,Rodrigo Dian de Oliveira Aguiar-Soares,Kelvinson Fernandes Viana,Ludmila Zanandreis de Mendonça,Ludmila Zanandreis de Mendonça,Mariana Ferreira Lanna,Mariana Ferreira Lanna,Denise da Silveira-Lemos,Rodrigo Correa-Oliveira,Olindo Assis Martins-Filho,Ricardo Toshio Fujiwara,Cláudia Martins Carneiro,Alexandre Barbosa Reis,Alexandre Barbosa Reis,Rodolfo Cordeiro Giunchetti +15 more
TL;DR: It is concluded that vaccination of dogs with LBSap vaccine induced a long-lasting type 1 immune response against L. chagasi challenge infection.
Journal ArticleDOI
Risk profile for Leishmania infection in dogs coming from an area of visceral leishmaniasis reemergence.
Gleisiane Gomes de Almeida Leal,Mariângela Carneiro,Aimara da Costa Pinheiro,Luana Araújo Marques,Henrique Gama Ker,Alexandre Barbosa Reis,Wendel Coura-Vital +6 more
TL;DR: A strong reemergence of canine visceral leishmaniasis after the discontinuation of the control programs is suggested and the observed risk factors reinforce the role of health education and environmental management measures to the effective control of the disease.
Journal ArticleDOI
Cost-effectiveness of meglumine antimoniate versus miltefosine caregiver DOT for the treatment of pediatric cutaneous leishmaniasis.
Brandon A. Berger,Alexandra Cossio,Nancy G. Saravia,Maria del Mar Castro,Sergio I. Prada,Allison H. Bartlett,Mai T. Pho +6 more
TL;DR: Treatment of pediatric cutaneous leishmaniasis with miltefosine via cDOT is cost saving from patient and societal perspectives, and moderately more costly from the government payer perspective compared to treatment with MA.
Journal ArticleDOI
Clinical and epidemiological characteristics of visceral leishmaniasis in children hospitalized at a reference university hospital in the north of Minas Gerais, Brazil
Ludmila Mourão Xavier-Gomes,Wagner Barreto Costa,Patrícia Fernandes do Prado,Maryane Oliveira-Campos,Maisa Tavares de Souza Leite +4 more
TL;DR: A partir das caracteristicas clinicas e epidemiologicas identificadas no estudo, sugere-se uma observacao mais eficaz por parte dos profissionais de saude, visando ao reconhecimento precoce e tratamento adequado da doenca e suas complicacoes.
Journal ArticleDOI
Ancient Leishmania coronin (CRN12) is involved in microtubule remodeling during cytokinesis
TL;DR: It is shown that Leishmania coronin preferentially distributes to the distal tip during cytokinesis, and interacts with microtubules through a microtubule-based motor, kinesin K39, which is essentially required for survival of these parasites in culture.
References
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Journal ArticleDOI
The increase in risk factors for leishmaniasis worldwide.
TL;DR: Increasing risk factors are making leishmaniasis a growing public health concern for many countries around the world, and some are related to a specific eco-epidemiological entity, others affect all forms of leish maniasis.
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Drug resistance in Indian visceral leishmaniasis.
TL;DR: Despite several disadvantages, amphotericin B is the only drug available for use in these areas and should be used as first‐line drug instead of Sbv, and the new oral antileishmanial drug miltefosine is likely to be the first-line drug in future.
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Rapid accurate field diagnosis of Indian visceral leishmaniasis
TL;DR: In this paper, a prospective study was conducted to assess the diagnostic usefulness of non-invasive testing for antibody to the leishmanial antigen K39 by means of antigen-impregnated nitrocellulose paper strips adapted for use under field conditions.
Journal ArticleDOI
Effect of insecticide-impregnated dog collars on incidence of zoonotic visceral leishmaniasis in Iranian children: a matched-cluster randomised trial.
TL;DR: Community-wide application of deltamethrin-impregnated dog collars not only protects domestic dogs from L infantum infections, but might also reduce the risk of L infantu infection in children.