Journal ArticleDOI
Leishmaniasis: current situation and new perspectives.
TLDR
Research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines, and the newly available control tools should allow a scaling up of control activities in priority areas.Abstract:
Leishmaniasis represents a complex of diseases with an important clinical and epidemiological diversity. Visceral leishmaniasis (VL) is of higher priority than cutaneous leishmaniasis (CL) as it is a fatal disease in the absence of treatment. Anthroponotic VL foci are of special concern as they are at the origin of frequent and deathly epidemics (e.g. Sudan). Leishmaniasis burden remains important: 88 countries, 350 million people at risk, 500,000 new cases of VL per year, 1-1.5 million for CL and DALYs: 2.4 millions. Most of the burden is concentrated on few countries which allows clear geographic priorities. Leishmaniasis is still an important public health problem due to not only environmental risk factors such as massive migrations, urbanisation, deforestation, new irrigation schemes, but also to individual risk factors: HIV, malnutrition, genetic, etc em leader Leishmaniasis is part of those diseases which still requires improved control tools. Consequently WHO/TDR research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines. The ongoing effort has already produced significant results. The newly available control tools should allow a scaling up of control activities in priority areas. In anthroponotic foci, the feasibility of getting a strong impact on mortality, morbidity and transmission, is high.read more
Citations
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Journal ArticleDOI
Age structure of owned dogs under compulsory culling in a visceral leishmaniasis endemic area
Danielly Vieira Bortoletto,Yuri Tani Utsunomiya,Silvia Helena Venturoli Perri,Fernando Ferreira,Cáris Maroni Nunes +4 more
TL;DR: The age structure of the dog population is essential for planning and evaluating control programs for zoonotic diseases and the estimated parameters can be further applied in models to maximize the impact and minimize financial inputs of visceral leishmaniasis control measures.
Journal ArticleDOI
Characterization of novel Leishmania infantum recombinant proteins encoded by genes from five families with distinct capacities for serodiagnosis of canine and human visceral leishmaniasis.
Geraldo G. S. Oliveira,Franklin B. Magalhães,Márcia Cristina Aquino Teixeira,Andrea Mendes Pereira,Cristiane Garboggini Melo de Pinheiro,Lenita Ramires dos Santos,Marília B. Nascimento,Cheila N. G. Bedor,Alessandra Lima de Albuquerque,Washington Luis Conrado dosSantos,Yara M. Gomes,Edson Duarte Moreira,Maria Edileuza Felinto de Brito,Lain Carlos Pontes de Carvalho,Osvaldo P. de Melo Neto +14 more
TL;DR: No single recombinant antigen was sufficient to serodiagnosis all canine or human VL cases, and different sensitivities and specificities when tested with serum samples from Leishmania-infected dogs and human patients with VL.
Journal ArticleDOI
Renal tubular dysfunction in patients with American cutaneous leishmaniasis
Rodrigo Alves de Oliveira,Lúcyo F.B. Diniz,Leonardo O. Teotônio,Cláudio G. Lima,Rosa Maria Salani Mota,Alice Maria Costa Martins,Talita Rojas Sanches,Antonio Carlos Seguro,Lucia Andrade,Geraldo B Júnior Silva,Geraldo B Júnior Silva,Alexandre Braga Libório,Elizabeth De Francesco Daher,Elizabeth De Francesco Daher +13 more
TL;DR: The urinary concentrating defect of ACL may be caused by decreased AQP2, with increased NKCC2 compensatory, and Pendrin upregulation may be related to the urinary acidification defect with increased NHE3 and H(+)-ATPase also compensatory.
Journal ArticleDOI
In Vitro and In Vivo Efficacy of Novel Flavonoid Dimers against Cutaneous Leishmaniasis
Iris L. K. Wong,Kin-Fai Chan,Yun-Fu Chen,Zhao-Rong Lun,Tak Hang Chan,Tak Hang Chan,Larry M.C. Chow +6 more
TL;DR: The present study suggests that flavonoid dimer 39 represents a new class of safe and effectiveLeishmanicidal agent against visceral and cutaneous leishmaniasis.
Journal ArticleDOI
In vitro antileishmanial activity of the medicinal plant - Satureja khuzestanica Jamzad
TL;DR: The aim of this study was to assess antiprotozoal activity of the ethanolic and methanolic extracts of leaf of Satureja khuzestanica against Leishmania major promastigotes.
References
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Journal ArticleDOI
The increase in risk factors for leishmaniasis worldwide.
TL;DR: Increasing risk factors are making leishmaniasis a growing public health concern for many countries around the world, and some are related to a specific eco-epidemiological entity, others affect all forms of leish maniasis.
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Drug resistance in Indian visceral leishmaniasis.
TL;DR: Despite several disadvantages, amphotericin B is the only drug available for use in these areas and should be used as first‐line drug instead of Sbv, and the new oral antileishmanial drug miltefosine is likely to be the first-line drug in future.
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Rapid accurate field diagnosis of Indian visceral leishmaniasis
TL;DR: In this paper, a prospective study was conducted to assess the diagnostic usefulness of non-invasive testing for antibody to the leishmanial antigen K39 by means of antigen-impregnated nitrocellulose paper strips adapted for use under field conditions.
Journal ArticleDOI
Effect of insecticide-impregnated dog collars on incidence of zoonotic visceral leishmaniasis in Iranian children: a matched-cluster randomised trial.
TL;DR: Community-wide application of deltamethrin-impregnated dog collars not only protects domestic dogs from L infantum infections, but might also reduce the risk of L infantu infection in children.