Journal ArticleDOI
Leishmaniasis: current situation and new perspectives.
TLDR
Research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines, and the newly available control tools should allow a scaling up of control activities in priority areas.Abstract:
Leishmaniasis represents a complex of diseases with an important clinical and epidemiological diversity. Visceral leishmaniasis (VL) is of higher priority than cutaneous leishmaniasis (CL) as it is a fatal disease in the absence of treatment. Anthroponotic VL foci are of special concern as they are at the origin of frequent and deathly epidemics (e.g. Sudan). Leishmaniasis burden remains important: 88 countries, 350 million people at risk, 500,000 new cases of VL per year, 1-1.5 million for CL and DALYs: 2.4 millions. Most of the burden is concentrated on few countries which allows clear geographic priorities. Leishmaniasis is still an important public health problem due to not only environmental risk factors such as massive migrations, urbanisation, deforestation, new irrigation schemes, but also to individual risk factors: HIV, malnutrition, genetic, etc em leader Leishmaniasis is part of those diseases which still requires improved control tools. Consequently WHO/TDR research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines. The ongoing effort has already produced significant results. The newly available control tools should allow a scaling up of control activities in priority areas. In anthroponotic foci, the feasibility of getting a strong impact on mortality, morbidity and transmission, is high.read more
Citations
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Journal ArticleDOI
In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth.
Michael Amoa-Bosompem,Mitsuko Ohashi,Mitsuko Ohashi,Mba Tihssommah Mosore,Jeffrey Agyapong,Nguyen Huu Tung,Kofi Dadzie Kwofie,Kofi Dadzie Kwofie,Frederick Ayertey,Kofi Baffuor Awuah Owusu,Isaac Tuffour,Philip Atchoglo,Georgina Isabella Djameh,Faustus Akankperiwen Azerigyik,Senyo K. Botchie,William Kofi Anyan,Regina Appiah-Opong,Takuhiro Uto,Osamu Morinaga,Alfred Ampomah Appiah,Irene Ayi,Yukihiro Shoyama,Daniel A. Boakye,Nobuo Ohta +23 more
TL;DR: Two of the three compounds, molucidin and ML-F52, are found to have anti-Leishmania activity against both strains, suggesting that compounds might inhibit cytokinesis in Leishmania parasites.
Journal Article
Anthroponotic Cutaneous Leishmaniasis in Nonendemic Quarters of a Centeral City in Iran
TL;DR: The present investigation revealed that Anthroponotic Cutaneous Leishmaniasis is in an epidemic status in these quarters in the city of Isfahan.
Journal ArticleDOI
Auricular leishmaniasis mimicking squamous cell carcinoma.
M-T Khorsandi-Ashtiani,Mehrdad Hasibi,Nasrin Yazdani,Joseph A. Paydarfar,F Sadri,Fatemeh Mirashrafi,Ali Kouhi +6 more
TL;DR: A rare case of auricular involvement by leishmaniasis is reported, to demonstrate the importance of thorough investigation of cutaneous head and neck lesions, and also of inclusion of infections such as leish maniasis in the differential diagnosis of Auricular lesions, especially in endemic areas.
Journal ArticleDOI
In vitro evaluation of traditionally used Surinamese medicinal plants for their potential anti-leishmanial efficacy.
Dennis R. A. Mans,T. Beerens,I. Magali,R.C. Soekhoe,Gerard J. Schoone,K. Oedairadjsingh,J.A. Hasrat,E. van den Bogaart,Henk D. F. H. Schallig +8 more
TL;DR: The S. lycocarpum preparation may be useful against leishmaniasis and may have a good safety index, warranting further investigations into its active constituents and mechanism(s) of action.
Journal ArticleDOI
Effect of allicin on promastigotes and intracellular amastigotes of Leishmania donovani and L. infantum
María Jesús Corral-Caridad,Inmaculada Moreno,Alfredo Toraño,Mercedes Domínguez,José María Alunda +4 more
TL;DR: Low toxicity for mammalian cells of this compound suggests the interest of exploring the value of allicin in combined therapy against leishmanial infections.
References
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Journal ArticleDOI
The increase in risk factors for leishmaniasis worldwide.
TL;DR: Increasing risk factors are making leishmaniasis a growing public health concern for many countries around the world, and some are related to a specific eco-epidemiological entity, others affect all forms of leish maniasis.
Journal ArticleDOI
Drug resistance in Indian visceral leishmaniasis.
TL;DR: Despite several disadvantages, amphotericin B is the only drug available for use in these areas and should be used as first‐line drug instead of Sbv, and the new oral antileishmanial drug miltefosine is likely to be the first-line drug in future.
Journal ArticleDOI
Rapid accurate field diagnosis of Indian visceral leishmaniasis
TL;DR: In this paper, a prospective study was conducted to assess the diagnostic usefulness of non-invasive testing for antibody to the leishmanial antigen K39 by means of antigen-impregnated nitrocellulose paper strips adapted for use under field conditions.
Journal ArticleDOI
Effect of insecticide-impregnated dog collars on incidence of zoonotic visceral leishmaniasis in Iranian children: a matched-cluster randomised trial.
TL;DR: Community-wide application of deltamethrin-impregnated dog collars not only protects domestic dogs from L infantum infections, but might also reduce the risk of L infantu infection in children.