Journal ArticleDOI
Leishmaniasis: current situation and new perspectives.
TLDR
Research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines, and the newly available control tools should allow a scaling up of control activities in priority areas.Abstract:
Leishmaniasis represents a complex of diseases with an important clinical and epidemiological diversity. Visceral leishmaniasis (VL) is of higher priority than cutaneous leishmaniasis (CL) as it is a fatal disease in the absence of treatment. Anthroponotic VL foci are of special concern as they are at the origin of frequent and deathly epidemics (e.g. Sudan). Leishmaniasis burden remains important: 88 countries, 350 million people at risk, 500,000 new cases of VL per year, 1-1.5 million for CL and DALYs: 2.4 millions. Most of the burden is concentrated on few countries which allows clear geographic priorities. Leishmaniasis is still an important public health problem due to not only environmental risk factors such as massive migrations, urbanisation, deforestation, new irrigation schemes, but also to individual risk factors: HIV, malnutrition, genetic, etc em leader Leishmaniasis is part of those diseases which still requires improved control tools. Consequently WHO/TDR research for leishmaniasis has been more and more focusing on the development of new tools such as diagnostic tests, drugs and vaccines. The ongoing effort has already produced significant results. The newly available control tools should allow a scaling up of control activities in priority areas. In anthroponotic foci, the feasibility of getting a strong impact on mortality, morbidity and transmission, is high.read more
Citations
More filters
Journal ArticleDOI
Insecticide susceptibility of Phlebotomus argentipes in visceral leishmaniasis endemic districts in India and Nepal.
Diwakar Singh Dinesh,Murari Lal Das,Albert Picado,Albert Picado,Lalita Roy,Suman Rijal,Shri Prakash Singh,Pradeep Das,Marleen Boelaert,Marc Coosemans +9 more
TL;DR: Investigation of the DDT and deltamethrin susceptibility of Phlebotomus argentipes in two countries with different histories of insecticide exposure found resistance to DDT was confirmed in Bihar and in a border village of Nepal, but the sand flies were still susceptible in villages more inside Nepal.
Journal ArticleDOI
Thiazole Ring-A Biologically Active Scaffold.
TL;DR: A literature survey regarding the topics from the year 2015 up to now was carried out as mentioned in this paper, where nearly 124 research articles were found, critically analyzed, and arranged regarding the synthesis and biological activities of thiazoles derivatives in the last 5 years.
Journal ArticleDOI
A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with meglumine antimoniate for the treatment of cutaneous leishmaniasis.
Evaldo Nascimento,Demetrios F. Fernandes,Edva P. Vieira,Antonio Campos-Neto,Jill A. Ashman,Fabiana P. Alves,Rhea N. Coler,Lisa Y. Bogatzki,Stuart J. Kahn,Anna Marie Beckmann,Samuel O. Pine,Karen D. Cowgill,Steven G. Reed,Franco M. Piazza +13 more
TL;DR: The LEISH-F1+MPL-SE vaccine was safe and immunogenic in CL patients and appeared to shorten their time to cure when used in combination with meglumine antimoniate chemotherapy.
Journal ArticleDOI
In Pursuit of Natural Product Leads: Synthesis and Biological Evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and Its Analogues: Discovery of N-(2-Benzoxazol-2-ylphenyl)benzamides as Novel Antileishmanial Chemotypes
Suresh K. Tipparaju,Sipak Joyasawal,Marco Pieroni,Marcel Kaiser,Reto Brun,Alan P. Kozikowski +5 more
TL;DR: The first synthesis and biological evaluation of antibiotic 31 (A-33853) and its analogues are reported and revealed 31 to be 3-fold more active than miltefosine, a known antileishmanial drug.
Journal ArticleDOI
Effect of village-wide use of long-lasting insecticidal nets on visceral Leishmaniasis vectors in India and Nepal: a cluster randomized trial.
Albert Picado,Murari Lal Das,Vijay Kumar,Shreekant Kesari,Diwakar Singh Dinesh,Lalita Roy,Suman Rijal,Pradeep Das,Mark Rowland,Shyam Sundar,Marc Coosemans,Marleen Boelaert,Clive R. Davies +12 more
TL;DR: The entomological evidence described here provides some evidence that LNs could be usefully deployed as part of the VL control program, and will confirm whether LNs should be adopted as a control strategy in the regional VL elimination programs.
References
More filters
Journal ArticleDOI
The increase in risk factors for leishmaniasis worldwide.
TL;DR: Increasing risk factors are making leishmaniasis a growing public health concern for many countries around the world, and some are related to a specific eco-epidemiological entity, others affect all forms of leish maniasis.
Journal ArticleDOI
Drug resistance in Indian visceral leishmaniasis.
TL;DR: Despite several disadvantages, amphotericin B is the only drug available for use in these areas and should be used as first‐line drug instead of Sbv, and the new oral antileishmanial drug miltefosine is likely to be the first-line drug in future.
Journal ArticleDOI
Rapid accurate field diagnosis of Indian visceral leishmaniasis
TL;DR: In this paper, a prospective study was conducted to assess the diagnostic usefulness of non-invasive testing for antibody to the leishmanial antigen K39 by means of antigen-impregnated nitrocellulose paper strips adapted for use under field conditions.
Journal ArticleDOI
Effect of insecticide-impregnated dog collars on incidence of zoonotic visceral leishmaniasis in Iranian children: a matched-cluster randomised trial.
TL;DR: Community-wide application of deltamethrin-impregnated dog collars not only protects domestic dogs from L infantum infections, but might also reduce the risk of L infantu infection in children.