Journal ArticleDOI
Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis.
Zhuochao Zhang,Xiao Li,Wei Sun,Shuqiang Yue,Jing-Yue Yang,Junjie Li,Ben Ma,Jianlin Wang,Xisheng Yang,Meng Pu,Bai Ruan,Ge Zhao,Qike Huang,Lin Wang,Kaishan Tao,Kefeng Dou +15 more
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TLDR
Data suggest that CAF-mediated HCC tumour progression is partially related to the loss of antitumour miR-320a in the exosomes of CAFs and that promoting the transfer of stromal cell-derived miR -320a might be a potential treatment option to overcome HCC progression.About:
This article is published in Cancer Letters.The article was published on 2017-07-01. It has received 216 citations till now. The article focuses on the topics: Stromal cell & Microvesicles.read more
Citations
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Effect of exosomal miRNA on cancer biology and clinical applications.
Zhenqiang Sun,Ke Shi,Shuaixi Yang,Jinbo Liu,Quanbo Zhou,Guixian Wang,Junmin Song,Zhen Li,Zhiyong Zhang,Weitang Yuan +9 more
TL;DR: The intercommunication occurring between different cells via exosomal miRNAs in tumor microenvironmnt is described, with impacts on tumor proliferation, vascularization, metastasis and other biological characteristics.
Journal ArticleDOI
Cell-to-cell communication: microRNAs as hormones.
TL;DR: The roles of miRNAs in intercellular communication, the biological function of extracellular mi RNAs, and their potential applications for diagnosis and therapeutics are discussed.
Journal ArticleDOI
The significance of exosomes in the development and treatment of hepatocellular carcinoma
TL;DR: The significance of exosomes in the occurrence, development, diagnosis and treatment of HCC is revealed to reveal, which in turn might help to further elucidate the mechanism of exOSomes in HCC, and promote the use ofExosomal substances in the clinical diagnosis and Treatment of H CC.
Journal ArticleDOI
Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p
Yao-yin Li,Yi-wei Tao,Shuo Gao,Pei Li,Jian-mao Zheng,Si-en Zhang,Jianfeng Liang,Yuejiao Zhang +7 more
TL;DR: It is found that the expression of miR-34a-5p in CAF-derived exosomes was significantly reduced, and fibroblasts could transfer exosomal miR+5p to OSCC cells, which might represent a therapeutic target for OSCC.
Journal ArticleDOI
Inflammatory breast cancer biology: the tumour microenvironment is key
TL;DR: This Review discusses intrinsic characteristics of IBC, extrinsic features of the TME and intrinsic–extrinsic communication, and hopes to develop the next generation of translational studies, which will lead to much-needed survival improvements in patients with this deadly disease.
References
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Journal ArticleDOI
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Douglas Hanahan,Lisa M. Coussens +1 more
TL;DR: Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types, which presents interesting new targets for anticancer therapy.
Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go.
Mercedes Tkach,Clotilde Théry +1 more
TL;DR: This Review focuses on the context of tumor cells and their microenvironment, but similar results and challenges apply to all patho/physiological systems in which EV-mediated communication is proposed to take place.
Journal ArticleDOI
Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
Journal ArticleDOI
Friends or foes - bipolar effects of the tumour stroma in cancer.
TL;DR: The restricted view of tumour progression as a multistep process defined by the accumulation of mutations in cancer cells has largely ignored the substantial contribution of the tumour microenvironment to malignancy.
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