Journal ArticleDOI
Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases
Bao-liang Sun,Li-hua Wang,Tuo Yang,Jing-yi Sun,Leilei Mao,Ming-feng Yang,Hui Yuan,Robert A. Colvin,Xiao-yi Yang +8 more
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TLDR
The clinical importance of ependymal route-based targeted gene therapy and intranasal drug administration in the brain by taking advantage of the unique role played by brain lymphatic pathways in the regulation of CSF flow and ISF/CSF exchange is highlighted.About:
This article is published in Progress in Neurobiology.The article was published on 2017-09-10. It has received 165 citations till now. The article focuses on the topics: Glymphatic system & Meningeal lymphatic vessels.read more
Citations
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Journal ArticleDOI
Effect of Cerebrospinal Fluid Circulation on Nose-to-Brain Direct Delivery and Distribution of Caffeine in Rats.
TL;DR: It is suggested that fluid circulation in the brain can be contribute to wider cerebral distribution of the drug after direct delivery from nose to brain after intranasal administration.
Journal ArticleDOI
Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors
TL;DR: In this article , the authors explored the major considerations and target factors in drug delivery through the nasal-brain route based on physiological knowledge and formulation research information, which will help to provide a mechanistic understanding of drug delivery and bring us one step closer to developing effective formulations and drugs in consideration of the key factors for nasal brain drug delivery.
Journal ArticleDOI
Epigenetic dysregulation of genes related to synaptic long-term depression among adolescents with depressive disorder and sleep symptoms
Antti-Jussi Ämmälä,Antti-Jussi Ämmälä,Anna-Sofia Urrila,Aleksandra Lahtinen,Olena Santangeli,Antti Hakkarainen,Katri Kantojärvi,Anu E. Castaneda,Nina Lundbom,Mauri Marttunen,Tiina Paunio +10 more
TL;DR: Among adolescents, depressive disorder with sleep symptoms is associated with a distinctive epigenetic pattern of DNA methylation in blood leukocytes, which emphasizes the role of sleep in synaptic plasticity and the widespread physiological consequences of disturbed sleep.
Journal ArticleDOI
Enduring neuroimmunological consequences of developmental experiences: from vulnerability to resilience
Jack Reddaway,Nichola M. Brydges +1 more
TL;DR: The effects of negative and positive environmental experiences, especially during development, in programming the long-term functioning of the neuroimmune system and the sparse but growing literature on sex differences in neuroimmune development and response to environmental experiences are reviewed.
Book ChapterDOI
The intra-brain distribution of brain targeting delivery systems
TL;DR: A number of nanomaterial-based techniques, including cell-penetrating peptide-based permeation-enhancing strategy and receptor-mediated targeting delivery, which have been widely explored to improving the delivery efficiency of brain drugs, are discussed in the second part of this chapter.
References
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Journal ArticleDOI
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Florent Ginhoux,Florent Ginhoux,Melanie Greter,Marylene Leboeuf,Sayan Nandi,Peter See,Solen Gokhan,Mark F. Mehler,Simon J. Conway,Lai Guan Ng,E. Richard Stanley,Igor M. Samokhvalov,Miriam Merad +12 more
TL;DR: Results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.
Journal ArticleDOI
The amyloid hypothesis of Alzheimer's disease at 25 years
Dennis J. Selkoe,John Hardy +1 more
TL;DR: In a recent study, this article showed that low cerebrospinal fluid (CSF) Aβ42 and amyloid-PET positivity precede other AD manifestations by many years.
Journal ArticleDOI
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Jeffrey J. Iliff,Minghuan Wang,Minghuan Wang,Yonghong Liao,Benjamin A. Plogg,Weiguo Peng,Georg Andreas Gundersen,Helene Benveniste,G. Edward Vates,Rashid Deane,Steven A. Goldman,Erlend A. Nagelhus +11 more
TL;DR: An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.
Journal ArticleDOI
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
Dale Schenk,Robin Barbour,Whitney Dunn,Grace Gordon,Henry Grajeda,Teresa Guido,Kang Hu,Jiping Huang,Kelly Johnson-Wood,Karen Khan,Dora Kholodenko,Michael K. Lee,Zhenmei Liao,Ivan Lieberburg,Ruth Motter,Linda Mutter,Ferdie Soriano,George Shopp,Vasquez Nicki J,Christopher Vandevert,Shannan Walker,Mark Wogulis,Ted Yednock,Dora Games,Peter Seubert +24 more
TL;DR: It is reported that immunization of the young animals essentially prevented the development of β-amyloid-plaque formation, neuritic dystrophy and astrogliosis, and treatment of the older animals markedly reduced the extent and progression of these AD-like neuropathologies.
Journal ArticleDOI
Sleep Drives Metabolite Clearance From the Adult Brain
Lulu Xie,Hongyi Kang,Qiwu Xu,Michael Chen,Yonghong Liao,Meenakshisundaram Thiyagarajan,John O’Donnell,Daniel J. Christensen,Charles Nicholson,Jeffrey J. Iliff,Takahiro Takano,Rashid Deane +11 more
TL;DR: It is reported that sleep has a critical function in ensuring metabolic homeostasis and convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep, suggesting the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.