Journal ArticleDOI
Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases
Bao-liang Sun,Li-hua Wang,Tuo Yang,Jing-yi Sun,Leilei Mao,Ming-feng Yang,Hui Yuan,Robert A. Colvin,Xiao-yi Yang +8 more
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TLDR
The clinical importance of ependymal route-based targeted gene therapy and intranasal drug administration in the brain by taking advantage of the unique role played by brain lymphatic pathways in the regulation of CSF flow and ISF/CSF exchange is highlighted.About:
This article is published in Progress in Neurobiology.The article was published on 2017-09-10. It has received 165 citations till now. The article focuses on the topics: Glymphatic system & Meningeal lymphatic vessels.read more
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Journal ArticleDOI
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Barry Boland,Wai Haung Yu,Olga Corti,Bertrand Mollereau,Alexandre Henriques,Erwan Bezard,Greg M. Pastores,David C. Rubinsztein,Ralph A. Nixon,Michael R. Duchen,Giovanna R. Mallucci,Guido Kroemer,Beth Levine,Eeva-Liisa Eskelinen,Fanny Mochel,Michael Spedding,Caroline Louis,Olivier R. Martin,Millan Mark +18 more
TL;DR: This article focuses on emerging mechanisms for promoting the clearance of neurotoxic proteins, a strategy that may curtail the onset and slow the progression of NDAs.
Journal ArticleDOI
Development and plasticity of meningeal lymphatic vessels.
Salli Antila,Sinem Karaman,Harri Nurmi,Mikko Airavaara,Merja H. Voutilainen,Thomas Mathivet,Dmitri Chilov,Zhilin Li,Tapani K. Koppinen,Jun-Hee Park,Shentong Fang,Aleksanteri Aspelund,Mart Saarma,Anne Eichmann,Jean-Leon Thomas,Jean-Leon Thomas,Kari Alitalo +16 more
TL;DR: It is shown that meningeal LVs develop postnatally, appearing first around the foramina in the basal parts of the skull and spinal canal, sprouting along the blood vessels and cranial and spinal nerves to various parts ofThe meninges surrounding the central nervous system (CNS).
Journal ArticleDOI
Circadian control of brain glymphatic and lymphatic fluid flow.
Lauren M. Hablitz,Virginia Plá,Michael Giannetto,Hanna S. Vinitsky,Frederik Filip Stæger,Tanner Metcalfe,Rebecca Nguyen,Abdellatif Benrais +7 more
TL;DR: It is shown that CSF distribution is under circadian control and that AQP4 supports this rhythm, suggesting distribution of CSF throughout the animal depends on time-of-day.
Journal ArticleDOI
Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein
TL;DR: The results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology.
Journal ArticleDOI
Mind-altering with the gut: Modulation of the gut-brain axis with probiotics.
TL;DR: The role of gut microbiota in bidirectional interactions between the gut and the brain, including neural, immune-mediated, and metabolic mechanisms are reviewed, and recent advances in the understanding of probiotic modulation of neurological and neuropsychiatric disorders via the gut-brain axis are highlighted.
References
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Book ChapterDOI
Atrial natriuretic peptide: its putative role in modulating the choroid plexus-CSF system for intracranial pressure regulation.
Conrad E. Johanson,John E. Donahue,A. Spangenberger,Edward G. Stopa,John A Duncan,Hari Shanker Sharma +5 more
TL;DR: Immunostaining is demonstrated not only in the choroidal epithelium, but also in the ependyma and some endothelial cells of cerebral microvessels in adult rats (Sprague-Dawley), substantiating the initial autoradiographic binding studies with 125I-ANP.
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Alzheimer's disease: Attack on amyloid-β protein
TL;DR: Interim results from a clinical trial of monthly infusions of aducanumab in subjects with prodromal or mild Alzheimer's disease support further development of aduecanumab as an Aβ-removing therapy.
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Lymphocyte targeting of the brain in adoptive transfer cryolesion-EAE.
TL;DR: It is suggested that focal central nervous system damage with drainage of auto‐antigens to regional lymph nodes in man may play a role in determining the site and timing of initial and recurrent multiple sclerosis lesions.
Journal ArticleDOI
Uptake of fibrillar β-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice
TL;DR: To charaterize the receptors involved in binding fibrillar amyloid A-beta (fAβ), the uptake of fAβ in microglia from wildtype and MSR-A knockout mice was compared to show a significant reduction in the uptake, which suggests that fA β gets internalized mostly byMSR-As inmicroglia.
Journal ArticleDOI
Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model.
Leena Paul,Meenu Madan,Matthias Rammling,Srinivasulu Chigurupati,Sic L. Chan,Jogi V. Pattisapu +5 more
TL;DR: Biphasic AQP1 expression in the CP with increased AQPs 1 and 4 at the brain-fluid interfaces may indicate compensatory mechanisms to regulate choroidal cerebrospinal fluid secretion and increase parenchymal fluid absorption in the high-pressure hydrocephalic condition.