Journal ArticleDOI
Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases
Bao-liang Sun,Li-hua Wang,Tuo Yang,Jing-yi Sun,Leilei Mao,Ming-feng Yang,Hui Yuan,Robert A. Colvin,Xiao-yi Yang +8 more
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TLDR
The clinical importance of ependymal route-based targeted gene therapy and intranasal drug administration in the brain by taking advantage of the unique role played by brain lymphatic pathways in the regulation of CSF flow and ISF/CSF exchange is highlighted.About:
This article is published in Progress in Neurobiology.The article was published on 2017-09-10. It has received 165 citations till now. The article focuses on the topics: Glymphatic system & Meningeal lymphatic vessels.read more
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Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Barry Boland,Wai Haung Yu,Olga Corti,Bertrand Mollereau,Alexandre Henriques,Erwan Bezard,Greg M. Pastores,David C. Rubinsztein,Ralph A. Nixon,Michael R. Duchen,Giovanna R. Mallucci,Guido Kroemer,Beth Levine,Eeva-Liisa Eskelinen,Fanny Mochel,Michael Spedding,Caroline Louis,Olivier R. Martin,Millan Mark +18 more
TL;DR: This article focuses on emerging mechanisms for promoting the clearance of neurotoxic proteins, a strategy that may curtail the onset and slow the progression of NDAs.
Journal ArticleDOI
Development and plasticity of meningeal lymphatic vessels.
Salli Antila,Sinem Karaman,Harri Nurmi,Mikko Airavaara,Merja H. Voutilainen,Thomas Mathivet,Dmitri Chilov,Zhilin Li,Tapani K. Koppinen,Jun-Hee Park,Shentong Fang,Aleksanteri Aspelund,Mart Saarma,Anne Eichmann,Jean-Leon Thomas,Jean-Leon Thomas,Kari Alitalo +16 more
TL;DR: It is shown that meningeal LVs develop postnatally, appearing first around the foramina in the basal parts of the skull and spinal canal, sprouting along the blood vessels and cranial and spinal nerves to various parts ofThe meninges surrounding the central nervous system (CNS).
Journal ArticleDOI
Circadian control of brain glymphatic and lymphatic fluid flow.
Lauren M. Hablitz,Virginia Plá,Michael Giannetto,Hanna S. Vinitsky,Frederik Filip Stæger,Tanner Metcalfe,Rebecca Nguyen,Abdellatif Benrais +7 more
TL;DR: It is shown that CSF distribution is under circadian control and that AQP4 supports this rhythm, suggesting distribution of CSF throughout the animal depends on time-of-day.
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Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein
TL;DR: The results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology.
Journal ArticleDOI
Mind-altering with the gut: Modulation of the gut-brain axis with probiotics.
TL;DR: The role of gut microbiota in bidirectional interactions between the gut and the brain, including neural, immune-mediated, and metabolic mechanisms are reviewed, and recent advances in the understanding of probiotic modulation of neurological and neuropsychiatric disorders via the gut-brain axis are highlighted.
References
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Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo.
TL;DR: Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived and are fully competent to present antigen to lymphocytes in an appropriately restricted manner.
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Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
Ronald Demattos,Kelly R. Bales,David J. Cummins,Jean-Cosme Dodart,Steven M. Paul,David M. Holtzman +5 more
TL;DR: Although peripheral administration of m266 to PDAPP mice markedly reduces Aβ deposition, m266 did not bind to Aβ deposits in the brain, and m266 appears to reduce brain Aβ burden by altering CNS and plasma Aβ clearance.
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How neuroinflammation contributes to neurodegeneration.
TL;DR: Observations indicate that therapies targeting glial cells might provide benefit for those afflicted by neurodegenerative disorders, because the environment is affected during disease in a cascade of processes collectively termed neuroinflammation.
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The Glymphatic System: A Beginner’s Guide
TL;DR: The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system.
Journal ArticleDOI
Clearance systems in the brain—implications for Alzheimer disease
Jenna M. Tarasoff-Conway,Roxana O. Carare,Ricardo S. Osorio,Lidia Glodzik,Tracy Butler,Els Fieremans,Leon Axel,Henry Rusinek,Charles Nicholson,Berislav V. Zlokovic,Blas Frangione,Kaj Blennow,Joël Ménard,Henrik Zetterberg,Thomas Wisniewski,Mony J. de Leon +15 more
TL;DR: The clearance systems of the brain as they relate to proteins implicated in AD pathology are described, with the main focus on Aβ.