Journal ArticleDOI
Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases
Bao-liang Sun,Li-hua Wang,Tuo Yang,Jing-yi Sun,Leilei Mao,Ming-feng Yang,Hui Yuan,Robert A. Colvin,Xiao-yi Yang +8 more
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TLDR
The clinical importance of ependymal route-based targeted gene therapy and intranasal drug administration in the brain by taking advantage of the unique role played by brain lymphatic pathways in the regulation of CSF flow and ISF/CSF exchange is highlighted.About:
This article is published in Progress in Neurobiology.The article was published on 2017-09-10. It has received 165 citations till now. The article focuses on the topics: Glymphatic system & Meningeal lymphatic vessels.read more
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Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Barry Boland,Wai Haung Yu,Olga Corti,Bertrand Mollereau,Alexandre Henriques,Erwan Bezard,Greg M. Pastores,David C. Rubinsztein,Ralph A. Nixon,Michael R. Duchen,Giovanna R. Mallucci,Guido Kroemer,Beth Levine,Eeva-Liisa Eskelinen,Fanny Mochel,Michael Spedding,Caroline Louis,Olivier R. Martin,Millan Mark +18 more
TL;DR: This article focuses on emerging mechanisms for promoting the clearance of neurotoxic proteins, a strategy that may curtail the onset and slow the progression of NDAs.
Journal ArticleDOI
Development and plasticity of meningeal lymphatic vessels.
Salli Antila,Sinem Karaman,Harri Nurmi,Mikko Airavaara,Merja H. Voutilainen,Thomas Mathivet,Dmitri Chilov,Zhilin Li,Tapani K. Koppinen,Jun-Hee Park,Shentong Fang,Aleksanteri Aspelund,Mart Saarma,Anne Eichmann,Jean-Leon Thomas,Jean-Leon Thomas,Kari Alitalo +16 more
TL;DR: It is shown that meningeal LVs develop postnatally, appearing first around the foramina in the basal parts of the skull and spinal canal, sprouting along the blood vessels and cranial and spinal nerves to various parts ofThe meninges surrounding the central nervous system (CNS).
Journal ArticleDOI
Circadian control of brain glymphatic and lymphatic fluid flow.
Lauren M. Hablitz,Virginia Plá,Michael Giannetto,Hanna S. Vinitsky,Frederik Filip Stæger,Tanner Metcalfe,Rebecca Nguyen,Abdellatif Benrais +7 more
TL;DR: It is shown that CSF distribution is under circadian control and that AQP4 supports this rhythm, suggesting distribution of CSF throughout the animal depends on time-of-day.
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Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein
TL;DR: The results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology.
Journal ArticleDOI
Mind-altering with the gut: Modulation of the gut-brain axis with probiotics.
TL;DR: The role of gut microbiota in bidirectional interactions between the gut and the brain, including neural, immune-mediated, and metabolic mechanisms are reviewed, and recent advances in the understanding of probiotic modulation of neurological and neuropsychiatric disorders via the gut-brain axis are highlighted.
References
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An Effector-Reduced Anti-β-Amyloid (Aβ) Antibody with Unique Aβ Binding Properties Promotes Neuroprotection and Glial Engulfment of Aβ
Oskar Adolfsson,Maria Pihlgren,Nicolas Toni,Yvan Varisco,Anna Lucia Buccarello,Katia Antoniello,Sophie Lohmann,Kasia Piorkowska,Valerie Gafner,Jasvinder Atwal,Janice A. Maloney,Mark Z. Chen,Alvin Gogineni,Robby M. Weimer,Deborah L. Mortensen,Michel Friesenhahn,Carole Ho,Robert Paul,Andrea Pfeifer,Andreas Muhs,Ryan J. Watts +20 more
TL;DR: It is proposed that a humanized IgG4 anti-Aβ antibody that takes advantage of a unique Aβ binding profile, while also possessing reduced effector function, may provide a safer therapeutic alternative for passive immunotherapy for AD.
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Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-β Load in an Alzheimer's Disease Mouse Model
Daniela Puzzo,Agnieszka Staniszewski,Shi Xian Deng,Lucia Privitera,Elena Leznik,Shumin Liu,Hong Zhang,Yan Feng,Agostino Palmeri,Donald W. Landry,Ottavio Arancio +10 more
TL;DR: It is demonstrated that the phosphodiesterase 5 inhibitor sildenafil (Viagra), a molecule that enhances phosphorylation of CREB, a molecule involved in memory, through elevation of cGMP levels, is beneficial against the AD phenotype in a mouse model of amyloid deposition.
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Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain
Delphine Boche,E. Zotova,Roy O. Weller,Seth Love,James Neal,Ruth M. Pickering,David Wilkinson,Clive Holmes,James A. R. Nicoll +8 more
TL;DR: The findings are consistent with the hypothesis that Abeta immunization results in solubilization of plaque Abeta42 which, at least in part, exits the brain via the perivascular pathway, causing a transient increase in the severity of CAA.
Journal ArticleDOI
Is There a Cerebral Lymphatic System
TL;DR: The distances between much of the brain tissue and the CSF compartments are too great for efficient clearance by simple diffusion, particularly for large molecules (such as peptides and proteins) with low diffusion coefficients.
Journal ArticleDOI
Caffeine reverses cognitive impairment and decreases brain amyloid-β levels in aged Alzheimer's disease mice.
Gary W. Arendash,Takashi Mori,Chuanhai Cao,Malgorzata Mamcarz,Melissa Runfeldt,Alexander Dickson,Kavon Rezai-Zadeh,Jun Tan,Bruce A. Citron,Xiaoyang Lin,Valentina Echeverria,Huntington Potter +11 more
TL;DR: Even with pre-existing and substantial Abeta burden, aged APPsw mice exhibited memory restoration and reversal of AD pathology, suggesting a treatment potential of caffeine in cases of established AD.