Journal ArticleDOI
Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases
Bao-liang Sun,Li-hua Wang,Tuo Yang,Jing-yi Sun,Leilei Mao,Ming-feng Yang,Hui Yuan,Robert A. Colvin,Xiao-yi Yang +8 more
Reads0
Chats0
TLDR
The clinical importance of ependymal route-based targeted gene therapy and intranasal drug administration in the brain by taking advantage of the unique role played by brain lymphatic pathways in the regulation of CSF flow and ISF/CSF exchange is highlighted.About:
This article is published in Progress in Neurobiology.The article was published on 2017-09-10. It has received 165 citations till now. The article focuses on the topics: Glymphatic system & Meningeal lymphatic vessels.read more
Citations
More filters
Journal ArticleDOI
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Barry Boland,Wai Haung Yu,Olga Corti,Bertrand Mollereau,Alexandre Henriques,Erwan Bezard,Greg M. Pastores,David C. Rubinsztein,Ralph A. Nixon,Michael R. Duchen,Giovanna R. Mallucci,Guido Kroemer,Beth Levine,Eeva-Liisa Eskelinen,Fanny Mochel,Michael Spedding,Caroline Louis,Olivier R. Martin,Millan Mark +18 more
TL;DR: This article focuses on emerging mechanisms for promoting the clearance of neurotoxic proteins, a strategy that may curtail the onset and slow the progression of NDAs.
Journal ArticleDOI
Development and plasticity of meningeal lymphatic vessels.
Salli Antila,Sinem Karaman,Harri Nurmi,Mikko Airavaara,Merja H. Voutilainen,Thomas Mathivet,Dmitri Chilov,Zhilin Li,Tapani K. Koppinen,Jun-Hee Park,Shentong Fang,Aleksanteri Aspelund,Mart Saarma,Anne Eichmann,Jean-Leon Thomas,Jean-Leon Thomas,Kari Alitalo +16 more
TL;DR: It is shown that meningeal LVs develop postnatally, appearing first around the foramina in the basal parts of the skull and spinal canal, sprouting along the blood vessels and cranial and spinal nerves to various parts ofThe meninges surrounding the central nervous system (CNS).
Journal ArticleDOI
Circadian control of brain glymphatic and lymphatic fluid flow.
Lauren M. Hablitz,Virginia Plá,Michael Giannetto,Hanna S. Vinitsky,Frederik Filip Stæger,Tanner Metcalfe,Rebecca Nguyen,Abdellatif Benrais +7 more
TL;DR: It is shown that CSF distribution is under circadian control and that AQP4 supports this rhythm, suggesting distribution of CSF throughout the animal depends on time-of-day.
Journal ArticleDOI
Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein
TL;DR: The results suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology.
Journal ArticleDOI
Mind-altering with the gut: Modulation of the gut-brain axis with probiotics.
TL;DR: The role of gut microbiota in bidirectional interactions between the gut and the brain, including neural, immune-mediated, and metabolic mechanisms are reviewed, and recent advances in the understanding of probiotic modulation of neurological and neuropsychiatric disorders via the gut-brain axis are highlighted.
References
More filters
Journal ArticleDOI
MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis.
Subhankar Mukhopadhyay,Yunying Chen,Marko Sankala,Leanne Peiser,Leanne Peiser,Timo Pikkarainen,Georg Kraal,Karl Tryggvason,Siamon Gordon +8 more
TL;DR: It is proposed that the TLR‐dependent induction of MARCO by innate immune stimulation enhances recognition and uptake of pathogenic organisms such as NM, thus contributing to host defence against infection.
Journal ArticleDOI
Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of β-Amyloid in TH1 and TH17 Versions of Experimental Autoimmune Encephalomyelitis
Jacqueline L Grant,Eliver Ghosn,Robert C. Axtell,Katja Herges,Hedwich F. Kuipers,Nathan Woodling,Katrin I. Andreasson,Leonard A. Herzenberg,Leonore A. Herzenberg,Lawrence Steinman +9 more
TL;DR: It was found that treatment with either Aβ42 or Aβ40 peptides reduced motor paralysis and brain inflammation in four different models of experimental autoimmune encephalomyelitis (EAE) with attenuation of motor paralysis, reduction of inflammatory lesions in the central nervous system (CNS), and suppression of lymphocyte activation.
Journal ArticleDOI
Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β.
Hye Rin Lee,Hwa Kyoung Shin,So Youn Park,Hye Young Kim,Won Suk Lee,Byung Yong Rhim,Ki Whan Hong,Chi Dae Kim +7 more
TL;DR: It is hypothesized that cilostazol attenuates Aβ production by increasing a disintegrin and metalloproteinase 10 (ADAM10)/α‐secretase activity via SIRT1‐coupled retinoic acid receptor‐β (RARβ) activation in N2a cells expressing human APP Swedish mutation.
Journal ArticleDOI
Differential aquaporin 4 expression during edema build-up and resolution phases of brain inflammation
Thomas Tourdias,Nobuyuki Mori,Iulius Dragonu,Nadège Cassagno,Claudine Boiziau,Justine Aussudre,Bruno Brochet,Chrit T. W. Moonen,Klaus G. Petry,Vincent Dousset +9 more
TL;DR: This animal model of brain inflammation demonstrated two phases of edema development: an initial edema build-up phase during active inflammation that peaked after 3 days and was followed by an edema resolution phase that lasted from 7 to 20 days post injection and was accompanied by glial scar formation.
Journal ArticleDOI
The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease
Kevin G. Burfeind,Charles Murchison,Shawn K. Westaway,Matthew J. Simon,Deniz Erten-Lyons,Jeffrey Kaye,Joseph F. Quinn,Jeffrey J. Iliff +7 more
TL;DR: A potential role for AQP4 in the development or progression of AD is suggested, but the relationship between of naturally occurring variants in the human AQP 4 gene and cognitive function has not yet been evaluated.