Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17
Jeannette J. Yu,Elvira Agrón,Traci E. Clemons,Amitha Domalpally,Freekje van Asten,Tiarnan D L Keenan,Catherine A Cukras,Emily Y. Chew,Frederick L. Ferris,John Paul SanGiovanni,Traci E Clemons,Anne S. Lindblad,Robert Lindblad,Nilay Shah,Robert D. Sperduto,Wendy McBee,Gary Gensler,Molly Harrington,A. K. Henning,Katrina Jones,Kumar Thotapally,Diana Tull,Valerie Watson,Kayla Williams,Christina Gentry,F. Kaufman,Chris Morrison,Elizabeth Saverino,Sherrie Schenning,Barbara Blodi,Matthew D. Davis,Kathy Glander,Gregory Guilfoil,Larry D. Hubbard,Kristine A. Johnson,Barbara Nardi,Michael W. Neider,Nancy Robinson,Eileen Rosensteel,Hugh D. Wabers,Grace Zhang,Antonio Capone,Bawa Dass,Kimberly A. Drenser,Bruce R. Garretson,Tarek S Hassan,Michael T. Trese,George A. Williams,Jeremy D. Wolfe,Tina L. Bell,Mary Zajechowski,Dennis Bezaire,F. McIver,Anthony Medina,Jackie Pagett,Stephanie Hatch Smith,Lynn Swartz,Tom Treuter,Andrew N. Antoszyk,Justin C. Brown,David J. Browning,Walter W. Holland,Angella S. Karow,Kelly Stalford,Angela K. Price,Sarah Ennis,Sherry Fredenberg,Jenna Herby,Uma M. Balasubramaniam,Loraine Clark,Donna McClain,Michael D. McOwen,Lynn Watson,Michael L. Klein,Steven T. Bailey,Thomas J. Hwang,Andreas K. Lauer,J. Timothy Stout,Patty McCollum,M. Johnson,Patrick B. Rice,Ivana K. Kim,John I. Loewenstein,Joan W. Miller,Lucia Sobrin,Lucy H. Young,Jacqueline Sullivan,Patricia Houlihan,Linda Merry,Ann Marie Lane,Ursula Lord Bator,Claudia Evans,Sarah Brett,Charleen Callahan,Marcia Grillo,David I. Walsh,Kamella Lau Zimmerman,Rajiv Anand,Lori E. Coors,Dwain G. Fuller,Rand Spencer,Robert C Wang,Karen Duignan,Sally Arceneaux,Hank Aguado,Nicholas Hesse,Michael Mackens,Brian Swan,Wai T. Wong,Monica Dalal,Naima Jacobs-El,Catherine B. Meyerle,Benjamin P. Nicholson,Henry E. Wiley,Katherine Shimel,Angel Garced,Janice Oparah,Greg Short,Alana Temple,Babilonia Ayukawa,Guy Foster,Darryl Hayes,Dessie Koutsandreas,Roula Nashwinter,John Rowan,Michael Bono,Denise Cunningham,Marilois Palmer,Alicia Zetina,David H. Orth,K.A. Rezaei,J. Civantos,Sohail Hasan,Kirk H. Packo,Celeste Figliulo,Pam Stanberry,Tara Farmer,Kiersten Nelson,Shannya Townsend-Patrick,Philip J. Rosenfeld,Royce W.S. Chen,Rishi R. Doshi,Sander R. Dubovy,Brian T. Kim,Matthew D. Lowrance,Andrew A. Moshfeghi,Zayna Nahas,Gary Schienbaum,John Vishak,Christina Y. Weng,Zohar Yehoshua,Belen Rodriguez,Jose Rebimbas,Jane Gleichauf,Mike Kicak,Jason Mena,Tim Odem,Elizabeth Sferza-Camp,Alicia Disgdiertt,Jim Oramas,Isabel Rams,Stephanie Thatcher,Susan B. Bressler,Neil M. Bressler,Daniel Finkelstein,Steven H. Sherman,Sharon D. Solomon,Howard S. Ying,Rita Denbow,Deborah A. Phillips,Elizabeth Radcliffe,Judy Belt,Dennis Cain,David Emmert,Mark Herring,Jacquelyn McDonald,G. Baker Hubbard,Chris S. Bergstrom,Blaine Cribbs,Andrew Hendrick,Brandon Johnson,Philip Laird,Sonia Mehta,Timothy W. Olsen,Justin H. Townsend,Jion Yan,Steven Yeh,Linda Curtis,Judy Brower,Hannah Yi,Jannah Rutter Dobbs,Debbie Jordan,Michael J. Elman,Robert A. Liss,Jo Ann Starr,Jennifer Belz,Charlene Putzulo,Teresa Coffey,Ashley Davis,Pamela V. Singletary,Giorya Shabi Andreani,Theresa Cain,Daniel Ketner,Peter Sotirakos,Suresh R. Chandra,Barbara A Blodi,Michael M. Altaweel,Ronald P. Danis,Justin L. Gottlieb,Michael S. Ip,Ronald Klein,T Michael Nork,Thomas S. Stevens,Kathryn Burke,Shelly Olson,Kristine A. Dietzman,Barbara Soderling,Guy Somers,Angie Wealti,Denise Krolnik,John Peterson,Sandra Reed,Thomas R. Friberg,Andrew W. Eller,Denise Gallagher,Leanne T. Labriola,Melissa Pokrifka,Aron Gedansky,Natalie Anthony,Cassandra Grzybowski,Dawn Matthews,Sharon Murajda-Jumba,Jessica Toro,David Callanan,Wayne A. Solley,Patrick Williams,Sandy Lash,Bob Boleman,Chris Dock,Gary E. Fish,Michel Shami,Brenda Arrington,Ashaki Meeks,Alan R. Margherio,Paul Raphaelian,Debra Markus,Justin Langdon,Elizabeth Truax,Sandy Lewis,Brad Terry,Alan J. Ruby,Amy S. Noffke,Kean Oh,Ramin Sarrafizadeh,Scott R. Sneed,Julie Hammersley,Serena Neal,Mary Doran,Nan Jones,Lisa Preston,Heather Jessick,Tanya Tracy Marsh,Michael J. Tolentino,Adam Berger,R. Hamilton,David Misch,Suk J. Moon,Dawn Sutherland,Vera Dilts,Sara Henderson,Esmeralda Medina,Donald Trueman,Laura Holm,Jason Strickland,Darmakusuma Ie,Jeffrey L. Lipkowitz,Kekul B. Shah,Susan Geraghty,Beverly Sannazzaro,Morgan Harper,Krista Bayer,Mary B. Lansing,Lauren B. Fox,Rebecca Lee,Jay B. Stallman,Michael J. Jacobson,Sean Koh,Scott Lampert,John B Miller,Mark Rivellese,Atul Sharma,Robert A. Stoltz,Stephanie Vanderveldt,Leslie Marcus,Starr Hendricks,Ryan Hollman,Grethel Betanzos,Leslie Ellorin,Shelly Fulbright,Debbie McCormick,Paul A. Edwards,Julianne Hall,Mary Monk,Melanie Gutkowski,Melina Mazurek,Janet Murphy,Katherine Gusas,Crystal Moffett,David Burley,Nicole Chesney,Katie Kilgo,Brian A. Rusinek,Bradley Stern,Tracy A. Troszak,Rhonda Baker-Levingston,Carl W. Baker,Tracey Caldwell,Tammy Walker,Lynnette F. Lambert,Tracey Martin,Mary Jill Palmer,T. Williams,Michael A. Novak,Joseph Coney,David G. Miller,Scott D. Pendergast,Lawrence J. Singerman,Nicholas Zakov,Hernando Zegarra,Kim DuBois,Susan Rath,Lori Revella,Tammy Brink,Kim Drury,Lisa Hogue,Mary Ilc,Connie Keller,Elizabeth McNamara,Vivian Tanner,Tamara Cunningham,John DuBois,Gregg Greanoff,Trina Nitzsche,Sheila Smith-Brewer,Ricky D. Isernhagen,John W. Kitchens,Thomas W. Stone,William J. Wood,Diana Holcomb,Virginia Therrien,Michelle Buck,Jeanne Van Arsdall,Edward A. Slade,Todd E. Schneiderman,David J. Spinak,Jackie Gaedke,Heather Davis Brown,Dan Helgren,Jenifer Garrison Pangelinan,Lawrence Halperin,Scott Anagnoste,Mandeep Dhalla,Krista D. Rosenberg,Barry Taney,W. Scott Thompson,Jaclyn Lopez,Monica Hamlin,Monica Lopez,Jamie Mariano,Evelyn Quinchia,Patricia Aramayo,Rita Veksler,Michael S. Lee,Richard F. Dreyer,Irvin Handelman,Colin Ma,Mark A. Peters,Stephen Hobbs,Amanda Milliron,Marcia Kopfer,Michele Connaughton,A. Christine Hoerner,R. Joseph Logan,Harry J. Wohlsein,David S. Boyer,Thomas G. Chu,Pouya Dayani,David Liao,Roger L. Novack,Firas M. Rahhal,Richard H. Roe,Homayoun Tabandeh,Janet Bayramyan,Tammy Gasparyan,Connie Hoang,Janet Kurokouchi,Tammy Eileen Lo,Richard Ngo,Mary Ann Nguyen,Michael Peyton,Charles Yoon,Julio Sierra,Adam Zamboni,Jeff Kessinger,Eric Protacio,Adam Smucker,Pamela Rath,Robert Bergren,Bernard H. Doft,Judy S. Liu,Karl R. Olsen,Lori Merlotti,Willia Ingram,Kellianne Marfisi,Kimberly Yeckel,Heather Schultz Carmelo,Amanda Fec,Keith McBroom,David M. Steinberg,Marc H. Levy,Jody Abrams,Melvin C. Chen,Waldemar Torres,Peggy Jelemensky,Mark Prybylski,Tara Raphael,Diana Appleby,Charlotte Rodman,Mark Sneath,Robert H. Rosa,Vanessa Hoelscher,Adelia Castano,J. Parker,John C. Hoskins,Nicholas G. Anderson,Joseph M. Googe,Tod A. McMillan,James Miller,Stephen L. Perkins,Kristina Oliver,Jennifer Beerbower,Bruce Gilliland,Cecile Hunt,Mike Jacobus,Raul Lince,Christopher Morris,Sarah Oelrich,Jerry Whetstone,Clement K. Chan,Steven G. Lin,Kim Walther,Tiana Gonzales,Lenise Myers,Kenneth M. Huff,David M. Brown,Eric Chen,Matthew S. Benz,Richard H. Fish,Rosa Y. Kim,James C. Major,Tien Pei Wong,Charles Wycoff,Cassandra Cone,Debbie Goates Gilaspia,Nubia Landaverde,Robert Smith,Deneva Zamora,Veronica Sneed,Melina Vela,Eric Kegley,Craig M. Greven,Shree Kurup,Charles Richards,M. Madison Slusher,Cara Everhart,Joan Fish,David Miller,Marshall Tyler,J. Michael Jumper,Arthur D. Fu,Robert N. Johnson,Brandon J. Lujan,H. Richard McDonald,Rosa Rodriguez,Nina Ansari,Jeanifer Joaquin,Silvia Linares,Lizette Lopez,Jessica Sabio,Sean Grout,Chad Indermill,Yesmin Urias,Roberto Zimmerman,Linda Margulies,Sara J. Schmidt,Joy L. Meier,Sherry L. Hadley,William Rosenthal,Barbara Johnson,Lois Swafford,Richard Shields,R. Scott Varner,Richard B Rosen,Ronald C. Gentile,Melissa Rivas,Katy W. Tai,Wanda Carrasquillo-Boyd,Robert Masini,Glenn L. Stoller,Ken Carnevale,Diane M. LaRosa,Barbara Burger,Tereza Conway,Carla Del Castillo,Julissa Diaz,Susan Jones,Nina Mondoc,Charlene Balfour,C. H. Vitha,Jennifer Lutz,Barbara McGinley,Fadi El Baba,Ann Marie Lavorna,Renee Jones,Jean Lewis,Ruth Tenzler,Mary Salvas-Mladek,Diane Van Kesteren,W. Copley McLean,W. Zachery Bridges,Cameron Stone,Denise Ammons,Mary Lamy,Andrea Menzel,Lea Doll Raymer,Barbara Campbell,Lisa Hawkins,Leslie Rickman,Lorraine Sherlin,Paula Price,Albert Sinyai,Ronald M. Kingsley,Reagan H. Bradford,Robert E. Leonard,Sonny Icks,Vanessa Bergman,Brittany Ross,Russ Burris,Amanda Butt,Rob Richmond,Alice T. Lyon,Manjot K. Gill,Lee M. Jampol,Rukhsana Mizra,Zuzanna Rozenbajgier,J. Chapman,L. Kaminski,Andrea Degillio,Evica Simjanoski,Jeffrey S. Heier,Hyung Cho,Tina Scheufele Cleary,Darin R. Goldman,Chirag P. Shah,Trexler M. Topping,Marissa Weber,Torsten Wiegand,Jeremy Schindelheim,Joy M. Bankert,Jennifer Stone,Alison Nowak,Sandy Chong,Lindsay Williams,Steven R. Bennett,Dennis Donovan,Margaret Graham,Cullen Jones,Anne Fung,Jan Kristine Bayabo,Razelda Bosch,Esperanza Cruz,Ashley Emerson,Alycia Fleming,Denice Barsness,Jorge Rodriguez,Marina Soboleva,Ingrid U. Scott,Esther M. Bowie,Kimberly A. Neely,David A. Quillen,Laura Walter,Timothy Bennett,James Strong,John A. Wells,Lloyd Clark,Peggy Miller,Mallie Taylor,Tiffany Swinford,Robbin Spivey,Michael J. Banach,Lawrence Ho,Richard Lanning,Thomas R. Pheasant,Jay G. Prensky,S.N. Truong,Julia Teatsworth,Michelle Dietrich,Ann Wasilus,Ann Miller,Megan Rakes,Teresa Slagle,Michelle Richards,Patricia Schuessler,Lacy Stover,Paul M. Beer,Naomi S. Falk,Mary Beth Shannon,Jeannie Olmeda,Don Berdeen,Joseph F. Fisher,James C. Folk,Stephen R. Russell,Barbara E. Taylor,Connie Hinz,Jean Walshire,Heather Stockman,Bruce Critser,Stefani Karakas,Cindy Montague,Randy Verdick,Omesh P. Gupta,Joseph I. Maguire,Christopher J. Brady,Francis Char DeCroos,Michael Dollin,Sunir J. Garg,Adam T. Gerstenblith,Julia A. Haller,Allen C. Ho,Jason Hsu,Richard S. Kaiser,John D. Pitcher,Carl D. Regillo,Rajiv Shah,Marc J. Spirn,William Tasman,James F. Vander,Noga Senderowitsch,Michele Formoso,Michelle Markun,Cedric George,Christina Centinaro,Lisa Grande,Stefanie Carey,Elaine Liebenbaum,Srinivas R. Sadda,Mark S. Humayun,Rachel Sierra,Elizabeth Corona,Margaret Padilla,Moonseok Nu,Sylvia Ramos,Cullen Barnett,Glenn Currie,Cornelia Gottlieb,Richard A. Garfinkel,Daniel M. Berinstein,Marcus H. Colyer,William Deegan,Michael Min-Shyue Lai,Robert L. Murphy,Michael Osman,Michael B. Rivers,Reginald J. Sanders,Manfred A. von Fricken,Debbie Oliver,Jeanne Kirshon,Tanya Alexander Snowden,Thomas Blondo,Alysia Cronise,Vanessa Denny,Kylie Mendez,Janine Newgen,Justin Davis,Mike Flory,Robert Frantz,Bryan Murphy,Steve Rauch,Judy E. Kim,Jane Bachman,Thomas B. Connor,Dennis P. Han,Kimberly Stepian,David V. Weinberg,William J. Wirostko,Krissa Packard,Tracy Kaczanowski,Vesper Williams,Vicki Barwick,Judy Flanders,Dennis B. Backes,Joe Beringer,Kristy Keller,Kathy Selchert,Paul S. Bernstein,Michael Teske,Albert T. Vitale,Susan Allman,Bonnie Carlstrom,Kimberley Wegner,Anne Haroldsen,Deborah Harrison,Cyrie Fry,James Gilman,Glen Jenkins,Paula Morris,Michael E. Rauser,Joseph T. Fan,Mukesh Suthar,Gisela Santiago,Kara Rollins Halsey,Christy Quesada,William Kiernan,Jesse Knabb,Richard A. Lewis,Cindy Dorenbach,Steven Spencer,Dana Barnett,Joseph F. Morales,Barron C. Fishburne,Jeffrey G. Gross,Michael A. Magee,Amy M. Flowers,Angie McDowell,Randall L. Price,Suber S. Huang,Johnny Tang,Shawn Wilker,Cherie Hornsby,Lisa Ferguson,Kirk Krogstad,Riva Adamovsky,Peggy Allchin,Kathleen Carlton,Claudia Clow,Kelly Sholtis,Stephanie Burke,Mark Harrod,Stacie Hrvatin,Geoffrey Pankhurst,Nelson R. Sabates,Michael Cassell,Komal Desai,Abraham Poulose,Felix N. Sabates,Yin Chen,Gary Gallimore,Yolanda Konior,Nicola Kim,Sami H. Uwaydat,Deborah Troillett,Karen Aletter,Robert N. Frank,Gary W. Abrams,James E. Puklin,Asheesh Tewari,Cheryl Milanovic,Melanie Bailey,David Griffith,Dena McDonald,Kit Morehead,Zlatan Sadikovic,Lisa Schillace,Elizabeth Silvis,Brian C. Joondeph,Nancy J. Christmas,David W. Johnson,Alan Kimura,Mimi Liu,Stephen Petty,John Zilis,Jenny Benitez,Cassandra Berryman Catlett,Eric Fluegel,Shane Mowry,Hoang Nguyen,David Reflow,Odette M. Houghton,Seema Garg,Maurice B. Landers,Travis A. Meredith,Sandy Barnhart,Megha Karmalkar,Debra Cantrell,Rona Lyn Esquejo-Leon,Linda Manor,Sue Pope,David Stines,Amelia Stokely,Dean P. 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Lim,Marcia Niec,Tametha Johnson,Yesenia Ovando,Catherine Nail Carroll,Mark Janowicz,Steven D. Schwartz,David Cupp,Michael B. Gorin,Gad Heilweil,Hamid Hosseini,Jean-Pierre Hubschman,Allan E. Kreiger,Tara Young McCannel,Carolyn K. Pan,David Sarraf,Irena Tsui,Joshua Udoetek,Vinad Voleti,Logan Hitchcock,Rosaleen Ostrick,Melissa Chun,Jennie Kageyama,Nilo Davila,Kristin Lipka,Christina Shin,Cynthia Owsley,Michael A. Albert,Richard M. Feist,John O. Mason,Martin L. Thomley,Angelia Johnson,Mark E. Clark,Tracy L. Emond,Joanna Hamela,Angela Marsh,Karen Searcey,Kia Rookard,Yu-Guang He,Rafael Ufret-Vincenty,Mike Molai,William Anderson,John Horna,Alan Letson,Colleen M. Cebulla,Susie Chang,Fred Davidorf,Jill A. Salerno,Laura Sladoje,Christina Stetson,Jeri Perry,Scott Savage,Cynthia A. Toth,Glenn J. Jaffe,Stefanie G. Schuman,Neeru Sarin,Jim Crowell,Tiffanie Keaton,Michael P. Kelly,Brian Lutman,Marriner Skelly,Lauren Welch,Lawrence S Morse,Allan A. 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TLDR
The genetic associations of drusenoid pigment epithelial detachment associated with age-related macular degeneration are consistent with genes associated with AMD progression, and progression rates to late AMD: geographic atrophy (GA) and neovascular (NV)-AMD.About:
This article is published in Ophthalmology.The article was published on 2019-02-01 and is currently open access. It has received 35 citations till now. The article focuses on the topics: Age-Related Eye Disease Study & Macular degeneration.read more
Citations
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Journal ArticleDOI
Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data: Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group
Richard F. Spaide,Glenn J. Jaffe,David Sarraf,K. Bailey Freund,Srinivas R. Sadda,Giovanni Staurenghi,Nadia K. Waheed,Usha Chakravarthy,Philip J. Rosenfeld,Frank G. Holz,Eric H. Souied,Salomon Y. Cohen,Giuseppe Querques,Kyoko Ohno-Matsui,David S. Boyer,Alain Gaudric,Barbara A Blodi,Caroline R. Baumal,Xiaoxin Li,Gabriel Coscas,Alexander J. Brucker,Lawrence J. Singerman,Phil Luthert,Steffen Schmitz-Valckenberg,Ursula Schmidt-Erfurth,Hans E. Grossniklaus,David J. Wilson,Robyn H. Guymer,Lawrence A. Yannuzzi,Emily Y. Chew,Karl G. Csaky,Jordi Monés,Daniel Pauleikhoff,Ramin Tadayoni,James G. Fujimoto +34 more
TL;DR: The study group suggests that the consensus standards outlined in this article be used in future reported studies of neovascular AMD and clinical practice.
Journal ArticleDOI
Role of Deep Learning-Quantified Hyperreflective Foci for the Prediction of Geographic Atrophy Progression.
Ursula Schmidt-Erfurth,Hrvoje Bogunovic,Christoph Grechenig,Patricia Bui,Maria Fabianska,Sebastian M Waldstein,Gregor Sebastian Reiter +6 more
TL;DR: Increased HRF concentrations in the junctional zone and future macular atrophy may represent progressive migration and loss of retinal pigment epithelium and AI-based biomarker monitoring may pave the way into the era of individualized risk assessment and objective decision making processes.
Book ChapterDOI
Age-Related Macular Degeneration: Epidemiology and Clinical Aspects.
TL;DR: In this article, the authors classified age-related macular degeneration (AMD) into early, intermediate, and late stages, and used risk prediction calculators to predict the risk of progression to late stages.
Journal ArticleDOI
Influence of pigment epithelial detachment on visual acuity in neovascular age-related macular degeneration
TL;DR: There is no strong evidence that the presence of a PED or aspects of its morphology has a significant impact on visual acuity, and more well-designed studies with standardised PED definitions and classifications are needed to evaluate the relationship between PED and visual Acuity.
Journal ArticleDOI
Comparison of OCT and OCTA manifestations among untreated PCV, neovascular AMD, and CSC in Chinese population
TL;DR: Combination of OCT and OCTA can effectively observe the significant alterations existed in PCV, CSC and nv-AMD, and there are distinctive differences among them.
References
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Journal ArticleDOI
Complement Factor H Polymorphism in Age-Related Macular Degeneration
Robert J. Klein,Caroline J. Zeiss,Emily Y. Chew,Jen-yue Tsai,Richard S. Sackler,Chad Haynes,A. K. Henning,John Paul SanGiovanni,Shrikant Mane,Susan T. Mayne,Michael B. Bracken,Frederick L. Ferris,Jurg Ott,Colin J. Barnstable,Josephine Hoh +14 more
TL;DR: A genome-wide screen for polymorphisms associated with age-related macular degeneration revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402 in the complement factor H gene.
Journal ArticleDOI
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
A. Kassoff,J. Kassoff,J. Buehler,M. Eglow,F. Kaufman,M. Mehu,S. Kieval,M. Mairs,B. Graig,A. Quattrocchi,David R. Jones,J. Locatelli,Alan J. Ruby,A Jr Capon,Bruce R. Garretson,Tarek S Hassan,Michael T. Trese,George A. Williams,V. Regan,P. Manatrey,P. Streasick,L. Szydlowski,F. McIver,C. Bridges,C. Stanley,K. Cumming,B. Lewis,Mary Zajechowski,R. R. Margherio,M. S. Cox,J. C. Werner,R. Falk,P. Siedlak,C. Neubert,Michael L. Klein,J. T. Stout,A. O'Malley,Andreas K. Lauer,Joseph E. Robertson,David J. Wilson,C. Beardsley,H. Anderson,P. Wallace,G. Smith,Shannon Howard,Richard F. Dreyer,C. Ma,R. G. Chenoweth,John Zilis,M. Johnson,Patrick B. Rice,H. Daniel,H. Crider,Stuart G Parker,K. Sherman,Daniel F. Martin,T M Sr Aaberg,P Jr Sternberg,Linda Curtis,B. Ju,James Gilman,B. Myles,S. Strittman,Christina Gentry,H. Yi,A Jr Capone,M. Lambert,Travis A. Meredith,T M Jr Aaberg,D. Saperstein,J. I. Lim,B. Stribling,D. Armiger,R. Swords,David H. Orth,T. P. Flood,J. Civantos,S. deBustros,Kirk H. Packo,Pauline T. Merrill,J. A. Cohen,Celeste Figliulo,Chris Morrison,D. A. Bryant,Don Doherty,M. McVicker,T. Drefcinski,J. M. Seddon,M. K. Pinnolis,N. Davis,I. Burton,T. Taitsel,David I. Walsh,J. Dubois-Moran,C. Callahan,Claudia Evans,K. K. Snow,D. A. Jones-Devonish,V. D. Crouse +98 more
TL;DR: People older than 55 years should have dilated eye examinations to determine their risk of developing advanced AMD and those with extensive intermediate size drusen, at least 1 large druse, noncentral geographic atrophy in 1 or both eyes, or advanced AMD or vision loss due to AMD in 1 eye should consider taking a supplement of antioxidants plus zinc.
Journal ArticleDOI
Causes and prevalence of visual impairment among adults in the United States.
Nathan Congdon,O'Colmain Bj,Caroline C W Klaver,Ronald Klein,Beatriz Munoz,David S. Friedman,John H. Kempen,Hugh R. Taylor,Paul Mitchell +8 more
TL;DR: The prevalence of visual disabilities will increase markedly during the next 20 years, owing largely to the aging of the US population.
Journal ArticleDOI
Clinical Classification of Age-related Macular Degeneration
Frederick L. Ferris,Charles P. Wilkinson,Alan C. Bird,Usha Chakravarthy,Emily Y. Chew,Karl G. Csaky,Srinivas R. Sadda +6 more
TL;DR: The proposed basic clinical classification scale seems to be of value in predicting the risk of late AMD, and incorporating consistent nomenclature into the practice patterns of all eye care providers may improve communication and patient care.
Journal ArticleDOI
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Lars G. Fritsche,Wilmar Igl,Jessica N. Cooke Bailey,Felix Grassmann,Sebanti Sengupta,Jennifer L. Bragg-Gresham,Kathryn P. Burdon,Scott J. Hebbring,Cindy Wen,Mathias Gorski,Ivana K. Kim,David Cho,Donald J. Zack,Donald J. Zack,Eric H. Souied,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Elisa Bala,Kristine ELee,David J. Hunter,Rebecca J. Sardell,Paul Mitchell,Joanna E. Merriam,Valentina Cipriani,Valentina Cipriani,Joshua D. Hoffman,Tina Schick,Yara T. E. Lechanteur,Robyn H. Guymer,Matthew P. Johnson,Yingda Jiang,Chloe M. Stanton,Gabri'lle H.S. Buitendijk,Xiaowei Zhan,Xiaowei Zhan,Alan M. Kwong,Alexis Boleda,Matthew Brooks,Linn Gieser,Rinki Ratnapriya,Kari Branham,Johanna R. Foerster,John R. Heckenlively,Mohammad Othman,Brendan J. Vote,Helena Liang,Emmanuelle Souzeau,Ian L. McAllister,Timothy Isaacs,Janette Hall,Stewart Lake,David A. Mackey,David A. Mackey,David A. Mackey,Ian J. Constable,Jamie E Craig,Terrie Kitchner,Zhenglin Yang,Zhenglin Yang,Zhiguang Su,Hongrong Luo,Daniel Chen,Hong Ouyang,Ken Flagg,Danni Lin,Guanping Mao,Henry Ferreyra,Klaus Stark,Claudia N von Strachwitz,Armin Wolf,Caroline Brandl,G. Rudolph,Matthias Olden,Margaux A. Morrison,Denise J. Morgan,Matthew Schu,Jeeyun Ahn,Giuliana Silvestri,Evangelia E. Tsironi,Kyu Hyung Park,Lindsay A. Farrer,Anton Orlin,Alexander J. Brucker,Mingyao Li,Christine A. Curcio,Saddek Mohand-Sa'd,José-Alain Sahel,Isabelle Audo,Mustapha Benchaboune,Angela J. Cree,Christina A Rennie,S. V. Goverdhan,Michelle Grunin,Shira Hagbi-Levi,Peter A. Campochiaro,Nicholas Katsanis,Frank G. Holz,Frédéric Blond,Frédéric Blond,Frédéric Blond,Hél'ne Blanché,Jean Fran ois Deleuze,Robert P. Igo,Barbara Truitt,Neal S. Peachey,Neal S. Peachey,Stacy M. Meuer,Chelsea E. Myers,Emily L. Moore,Ronald Klein,Michael A. Hauser,Eric A. Postel,Monique D. Courtenay,Stephen G. Schwartz,Jaclyn L. Kovach,William K. Scott,Gerald Liew,Ava Grace Tan,Bamini Gopinath,John C. Merriam,R. Theodore Smith,R. Theodore Smith,Jane C. Khan,Jane C. Khan,Jane C. Khan,Humma Shahid,Humma Shahid,Anthony T. Moore,Anthony T. Moore,Anthony T. Moore,J Allie McGrath,Renee Laux,Milam A. Brantley,Anita Agarwal,Lebriz Ersoy,Albert Caramoy,Thomas Langmann,Nicole T.M. Saksens,Eiko Kde Jong,Carel B. Hoyng,Melinda Cain,Andrea J. Richardson,Tammy M. Martin,John Blangero,Daniel E. Weeks,Bal Dhillon,Cornelia M. van Duijn,Kimberly F. Doheny,Jane Romm,Caroline C W Klaver,Caroline Hayward,Michael B. Gorin,Michael L. Klein,Paul N. Baird,Anneke I. den Hollander,Sascha Fauser,John R. WYates,John R. WYates,John R. WYates,Rando Allikmets,Jie Jin Wang,Debra A. Schaumberg,Debra A. Schaumberg,Barbara E.K. Klein,Stephanie A. Hagstrom,Itay Chowers,Andrew J. Lotery,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Kang Zhang,Kang Zhang,Murray H. Brilliant,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Anand Swaroop,Emily Y. Chew,Margaret A. Pericak-Vance,Margaret M. DeAngelis,Dwight Stambolian,Jonathan L. Haines,Sudha K. Iyengar,Bernhard H. F. Weber,Gon'alo R. Abecasis,Iris M. Heid +185 more
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.