Neurobiology of axonal transport defects in motor neuron diseases: opportunities for translational research?
Kurt J. De Vos,Majid Hafezparast +1 more
TLDR
Current understanding of axonal transport defects and the role they play in motor neuron diseases (MNDs) are reviewed with a specific focus on the most common form of MND, amyotrophic lateral sclerosis (ALS).About:
This article is published in Neurobiology of Disease.The article was published on 2017-09-01 and is currently open access. It has received 166 citations till now. The article focuses on the topics: Axoplasmic transport & Axon.read more
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
The role of mitochondria in amyotrophic lateral sclerosis
TL;DR: The alterations in mitochondrial parameters in ALS are reviewed and the common pathways to dysfunction are examined to examine the common routes to dysfunction.
Journal ArticleDOI
Amyotrophic lateral sclerosis: a clinical review
TL;DR: Different aspects of ALS are discussed, including epidemiology, aetiology, pathogenesis, clinical features, differential diagnosis, investigations, treatment and future prospects.
Journal ArticleDOI
Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Phuong H. Nguyen,Ayyalusamy Ramamoorthy,Bikash R. Sahoo,Jie Zheng,Peter Faller,John E. Straub,Laura Dominguez,Joan-Emma Shea,Nikolay V. Dokholyan,Alfonso De Simone,Alfonso De Simone,Buyong Ma,Buyong Ma,Ruth Nussinov,Saeed Najafi,Son Tung Ngo,Antoine Loquet,Mara Chiricotto,Pritam Ganguly,James McCarty,Mai Suan Li,Carol K. Hall,Yiming Wang,Yifat Miller,Simone Melchionna,Birgit Habenstein,Stepan Timr,Jiaxing Chen,Brianna Hnath,Birgit Strodel,Rakez Kayed,Sylvain Lesné,Guanghong Wei,Fabio Sterpone,Andrew J. Doig,Philippe Derreumaux,Philippe Derreumaux +36 more
TL;DR: In this paper, the authors review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (Aβ, tau), α-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer's disease, Parkinson's disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research.
References
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
HDAC6 is a microtubule-associated deacetylase
Charlotte Hubbert,Amaris Guardiola,Rong Shao,Yoshiharu Kawaguchi,Akihiro Ito,Andrew B. Nixon,Minoru Yoshida,Xiao-Fan Wang,Tso-Pang Yao +8 more
TL;DR: The results show that HDAC6 is the tubulin deacetylase, and provide evidence that reversible acetylation regulates important biological processes beyond histone metabolism and gene transcription, including microtubule-dependent cell motility.
Journal ArticleDOI
SeminarAmyotrophic lateral sclerosis
Matthew C Kiernan,Steve Vucic,Benjamin C. Cheah,Martin R Turner,Andrew Eisen,Orla Hardiman,James R. Burrell,Margaret C. Zoing +7 more
TL;DR: This paper summarized current concepts about the origin of the disease, what predisposes patients to develop the disorder, and discuss why all cases of ALS are not the same, focusing on the small steps of extending longevity, improving therapies, undertaking clinical trials, and compiling population registries to the overarching goals of establishing the measures that guard against onset and finding the triggers for this neurodegenerative disorder.
Journal ArticleDOI
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
TL;DR: Human brain tau and paired helical filament polypeptides co-migrated on sodium dodecyl sulfate-polyacrylamide gels suggest that tau is a major component of Alzheimer paired helicals filaments.
Journal ArticleDOI
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
Gentry N. Patrick,Lawrence R. Zukerberg,Margareta Nikolic,Margareta Nikolic,Suzanne M. de la Monte,Pieter Dikkes,Li-Huei Tsai,Li-Huei Tsai +7 more
TL;DR: It is found that p25, a truncated form of p35, accumulates in neurons in the brains of patients with Alzheimer's disease, and this accumulation correlates with an increase in Cdk5 kinase activity.
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