PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Proteomic analysis of mesenchymal to Schwann cell transdifferentiation.
Anup D. Sharma,Jayme Wiederin,Metin Uz,Pawel Ciborowski,Surya K. Mallapragada,Howard E. Gendelman,Donald S. Sakaguchi +6 more
TL;DR: A number of MSC proteins were significantly regulated following transdifferentiation of the MSCs supporting roles in axonal guidance, myelination, neural development and differentiation, and these reported results can affect a wide field of stem cell biology, tissue engineering, and proteomics.
Journal ArticleDOI
High-voltage electrical stimulation improves nerve regeneration after sciatic crush injury
Rosana Macher Teodori,Andréia Maria Silva,Meiricris T. Silva,L. S. Oliveira,Maria L. O. Polacow,Elaine Caldeira de Oliveira Guirro +5 more
TL;DR: In this paper, the effect of high-voltage electrical stimulation (HVES) on the morphometric and functional characteristics of the regenerated nerve after crush injury in rats was investigated.
Journal ArticleDOI
Comparative proteomic analysis of differentially expressed proteins between peripheral sensory and motor nerves.
TL;DR: It is anticipated that the database generated in this study will provide a solid foundation for further comprehensive investigation of functional differences between sensory and motor nerves, including the specificity of their regeneration.
Journal ArticleDOI
Changes of peroxisome proliferator-activated receptor-γ on crushed rat sciatic nerves and differentiated primary Schwann cells.
TL;DR: In this paper, the expression of PPAR-γ decreases mainly in Schwann cells, and it was also increased in differentiated SchwANN cells, indicating that PPARγ could promote Schwann cell differentiation, which plays an important role in peripheral nerve injury and regeneration.
Journal ArticleDOI
Glutamatergic Reinnervation and Assembly of Glutamatergic Synapses in Adult Rat Skeletal Muscle Occurs at Cholinergic Endplates
Maura Francolini,Giorgio Brunelli,Ilaria Cambianica,Sergio Barlati,Alessandro Barbon,Luca La Via,Bruno Guarneri,F. Boroni,Annamaria Lanzillotta,Cristina Baiguera,Michele Ettorre,Mario Rosario Buffelli,PierFranco Spano,Francesco Clementi,Marina Pizzi +14 more
TL;DR: Results indicate that cholinergic endplates can be targeted by new glutamatergic projections and that the clustering of AMPA receptors occurs there.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
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Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.