PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Ultrastructural observations on the progress of nerve degeneration and regeneration at the suture site following vagal-hypoglossal nerve coaptation in cats.
Ming E. Hu,Yeu Sheng Tyan,Peng Wei Hsu,Jee Ching Hsu,Hung Ming Chang,Eng-Ang Ling,Chyn-Tair Lan +6 more
TL;DR: The subtle remodeling of the nerve in cross-coaptation may be far greater than previously recognized, and this may have clinical importance since patients undergoing nerve crossover microsurgery exhibit delayed motor rehabilitation, apparently as a direct result of a change in target innervation.
Facteurs cellulaires et moléculaires influençant la régénération axonale dans les systèmes nerveux central et périphérique
TL;DR: Examination of mRNA expression for the most studied myelin-associated inhibitors in the brain before and after a spinal cord contusion shows that NGR1, NGR2 and LINGO-1 are widely expressed throughout the mouse brain, and suggests that the limited access of immune cells in the injured CNS could be, at least partly, responsible for the lack of regeneration of central axons.
Journal ArticleDOI
TrkA inhibitor promotes motor functional regeneration of recurrent laryngeal nerve by suppression of sensory nerve regeneration
Hiroshi Suzuki,Koji Araki,Toshiyasu Matsui,Toshiyasu Matsui,Yuya Tanaka,Kosuke Uno,Masayuki Tomifuji,Taku Yamashita,Taku Yamashita,Yasushi Satoh,Yasushi Kobayashi,Akihiro Shiotani +11 more
TL;DR: The effect of TrkA inhibitors is demonstrated, which blocks the NGF-TrkA pathway that acts on the sensory/automatic nerves thus preventing misdirected regeneration among motor and sensory nerves, and thereby promoting the regeneration of motor neurons to achieve functional recovery.
Journal ArticleDOI
Efficient gene transfer into primary muscle cells to analyze nerve-independent postsynaptic organization in vitro.
Jessica Mella,Viviana Pérez,Diego Zelada,Nicolás Moreno,Ariel Ionescu,Eran Perlson,Juan Pablo Henríquez +6 more
TL;DR: These methods in primary muscle cells are a valuable tool to perform a detailed and accurate analysis of the potential role of muscle-derived proteins on the maintenance of complex postsynaptic structures and to identify nerve-derived signals regulating functional NMJ maturation.
Journal Article
Electrophysiological Study of Sciatic Nerve Regeneration Through Tubes Seeded with Schwann Cells
TL;DR: (Yin, Kemp, Yu, Wagstaj, & Frostick, 2001) but needs favorable environment (Yin et al., 2001).
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
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Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.