PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
More filters
Journal ArticleDOI
■ REVIEW : Gene Expression in Nerve Regeneration
TL;DR: This work reports on more than 60 genes and their products that show a specific pattern of regulation following peripheral nerve lesion and discusses established or putative mo lecular interrelationships and functions with respect to the contribution of these genes/gene products to the molecular regeneration program of the PNS.
Patent
Self-assembling cell aggregates and methods of making engineered tissue using the same
TL;DR: In this paper, a composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing is presented. But, the authors do not specify a set of cell embedding patterns.
Patent
Medical guide tubes
TL;DR: In this paper, a tubular guide tube for nerve regeneration was microbraided around a mandrel to make a tube, which was tested in the rat sciatic nerve model with a 12 mm gap.
Journal ArticleDOI
Minimally invasive Morton's intermetatarsal neuroma decompression.
TL;DR: The technique is simple, the postoperative morbidity to the patient is minimal, and the results in this limited number of patients was encouraging.
Book ChapterDOI
Role for semaphorin III and its receptor neuropilin-1 in neuronal regeneration and scar formation?
TL;DR: This chapter focuses on recent observations that suggest a possible role for semaphorin III and its recently identified receptor neuropilin- 1 in axonal regeneration and scar formation in the PNS and CNS.
References
More filters
Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.