PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides
Wouter A.J. Nijenhuis,Nienke Wanders,John A. W. Kruijtzer,Rob M. J. Liskamp,Willem Hendrik Gispen,Roger A.H. Adan +5 more
TL;DR: Melanocortin receptor ligands accelerate functional recovery after peripheral nerve crush but do not accelerate sensory recovery via interaction with the melanoc Cortin MC4 receptor, suggesting that melanocortins do not accelerated sensory recovery through interaction with this receptor.
Journal ArticleDOI
Re‐innervation and recovery of rat soleus muscle and motor unit function after nerve crush
D Leterme,F Tyč +1 more
TL;DR: The results demonstrate for the first time a process of progressive axonal re‐innervation by the axotomized motoneurones and provide a functional picture of the effective restoration of the neuromuscular function.
Journal ArticleDOI
Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response
Rickard P. F. Lindblom,Rickard P. F. Lindblom,Rickard P. F. Lindblom,Alexander Berg,Mikael Ström,Shahin Aeinehband,Cecilia A. Dominguez,Faiez Al Nimer,Nada Abdelmagid,Matthias Heinig,Johan Zelano,Karin Harnesk,Norbert Hubner,Bo Nilsson,Kristina Nilsson Ekdahl,Margarita Diez,Staffan Cullheim,Fredrik Piehl +17 more
TL;DR: It is demonstrated that local expression of Cr2 in the central nervous system is part of the axotomy reaction and is suggested to modulate subsequent complement mediated effects.
Journal ArticleDOI
Atorvastatin is beneficial for muscle reinnervation after complete sciatic nerve section in rats
TL;DR: Systemic administration of Atorvastatin for 14 days after lesion was beneficial in improving locomotion capability associated with the re-establishment of muscle strength and EMG activity.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.