PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Dissertation
Sensory neuron insulin signaling and its role in diabetic neuropathy
TL;DR: This dissertation presents a meta-analyses of the In vivo Peripheral Nervous System Insulin Resistance in Diabetic Neuropathy and its role in the management of diabetes and its complications.
DissertationDOI
The septin cytoskeleton is associated with distinct myelin structures of the central and peripheral nervous system
TL;DR: It is shown here that myelinating Schwann cells tolerate the loss of Sept2, which might be due to such compensation mechanisms, and it is proposed that septin/myelin membrane complexes play an important role in myelination.
Journal ArticleDOI
Intestinal ischemia–reperfusion induced diaphragm contractility dysfunction: Electrophysiological and ultrastructural study in a neonatal rat model
TL;DR: Impairment in the diaphragm contractility and neuropathic changes in the phrenic nerve occurred even in the first hour of reperfusion, and NAC administration prevented these detrimental effects.
Journal ArticleDOI
Experimetal microneurosurgery of the central and peripheral nervous system in the study of the neuronal and glial trophism and plasticity
TL;DR: The findings suggest that glial reaction synthesizing neurotrophic factors may influence the wound and repair after mechanical lesions of central nervous and subsequent neuronal trophism and plasticity which may be relevant to the regenerative process of the nervous tissue.
Journal ArticleDOI
Comparison of neurovascular characteristics of facial skin in patients after primary and revision rhytidectomies
Farhad Ardeshirpour,Elisabeth Hurliman,Gwen Wendelschafer-Crabb,Brian D. McAdams,Peter A. Hilger,William R. Kennedy,Amy Anne D. Lassig,Michael Brenner +7 more
TL;DR: Previous skin elevation was associated with decreased epidermal nerve fiber density and qualitative changes in dermal nerves, capillaries, and mast cells in a clinical sample of patients undergoing rhytidectomy, and future research is needed to determine whether histological findings predict wound healing.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.