PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination.
TL;DR: An important role for neurosteroids in myelin repair has been demonstrated in the rodent sciatic nerve, where progesterone and its direct precursor pregnenolone are synthesized by Schwann cells.
Journal ArticleDOI
Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease
Carla Teixeira,Catarina Oliveira Miranda,Catarina Oliveira Miranda,Vera Sousa,Vera Sousa,Telma Emanuela Santos,Ana R. Malheiro,Melani Solomon,Gustavo Maegawa,Pedro Brites,Mónica Mendes Sousa +10 more
TL;DR: The identification of the axonal defects that precede demyelination in Krabbe's disease, together with the finding that Twitcher axons are regeneration-competent when axonopathy is already installed, opens new windows of action to effectively correct the neuropathology that characterizes this disorder.
Journal ArticleDOI
Extensive neuronal cell death following intracranial transection of the facial nerve in the adult rat.
TL;DR: The intracranial lesion model used in the present study generates a massive neuronal cell death and should therefore be a useful tool for studies on proximal cranial nerve injuries and in particular mechanisms causing cell death, which may occur following, for example, head trauma.
Journal ArticleDOI
The effect of aging on efferent nerve fibers regeneration in mice.
TL;DR: The results indicate that, after injuries of peripheral nerves, axonal regeneration and reinnervation are maintained throughout life, but tend to be more delayed and slightly less effective with aging.
Book ChapterDOI
Neurosteroids: From Definition and Biochemistry to Physiopathologic Function
TL;DR: The relationships between steroid hormones and brain function have mostly been envisioned within the framework of endocrine mechanisms as responses elicited by secretory products of steroidogenic endocrine glands, borne by the blood stream, and exerting actions on the brain.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.