PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Role of glial cells in axonal regeneration.
Dana Toy,Uk Namgung +1 more
TL;DR: This review evaluates the roles of Schwann cells and astrocytes in axonal regeneration and examines recent evidence that suggests a dual function of astroCytes in regenerative responses, and discusses the role of Cdc2 pathways in axonic regeneration.
Journal ArticleDOI
M‐type K⁺ channels in peripheral nociceptive pathways
TL;DR: In this article, the authors discuss the emerging data on the expression in pain pathways, functional role and modulation of a family of voltage-gated K+ channels called "M channels" (KCNQ, Kv 7), and discuss the therapeutic potential of M channels as analgesic drug targets.
Journal ArticleDOI
Enhancing Schwann cell migration using concentration gradients of laminin-derived peptides
Cecilia M.M. Motta,Kevin J. Endres,Chrys Wesdemiotis,Rebecca Kuntz Willits,Matthew L. Becker,Matthew L. Becker +5 more
TL;DR: The response of SC to these tethered peptide gradients will guide the development of translationally relevant constructs designed to facilitate endogenous SC infiltration into defects for nerve regeneration.
Journal ArticleDOI
Surface biology of collagen scaffold explains blocking of wound contraction and regeneration of skin and peripheral nerves.
TL;DR: The newly understood mechanism of biological (regenerative) activity of a collagen scaffold (dermis regeneration template, DRT) provides a relatively complete paradigm of regenerative medicine that can be used to prepare scaffolds that may induce regeneration of other organs in future studies.
Journal ArticleDOI
Recovery of laryngeal function after intraoperative injury to the recurrent laryngeal nerve
TL;DR: This review aims to provide an update on the current understandings of surgically-induced injury to the laryngeal nerves to clarify any differences between the transient and permanent injury of the RLN.
References
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The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.