PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Regeneração de nervo periférico por meio da coaptação com cola de fibrina
Eduardo José Danza Vicente,Antonio de Castro Rodrigues,Priscila Cadima Vicente,Cláudia Helena Cerqueira Mármora,Paula Silva de Carvalho Chagas,Sueli Maria dos Reis Santos +5 more
TL;DR: The nerve coaptation by the use of fibrin glue regenerated the lesion in the peroneal nerve, however the morphological pattern of the regeneration was compared to the perOneal nerve without lesion.
Journal ArticleDOI
Decreased receptivity of pathway connective tissue to sympathetic nerve ingrowth in the developing rat.
TL;DR: The findings that connective tissue pathways are better substrates for sympathetic sprouting in the neonatal rat supports the view that developmental changes in these tissues are likely to contribute to the impaired reinnervation of orbital targets by contralateral neurons in juvenile and adult rats.
Growth Factor Delivery From Fibrin Matrics Containing Affinity-Based Delivery Systems To Treat Peripheral Nerve Injury
TL;DR: This thesis work sought to develop a biomaterial to further the understanding of affinitybased delivery and to serve as a potential treatment for peripheral nerve injury.
Journal ArticleDOI
Schwann cells promote neuronal differentiation of bone marrow stromal cells
Xiao dong Zhi,Gang Lv +1 more
TL;DR: It was found that a large scale of BMSCs showed a typical neuronal morphology and axon extended about 10 day after beginning of co-culture, which support the transdifferentiation of B MSCs, and the theoretical utility of these cells for the treatment of degenerative and acquired disorders of the nervous system and spinal cord injury.
Journal ArticleDOI
Schwann cells can misdirect regrowing neuronal processes
TL;DR: Studies of potentials for dorsal spinal nerve root axons to regrow into the spinal cord involved placement of the tracer HRP/WGA-HRP on the cut end of the nerve root and analysis revealed that spinal neurons influenced by the presence of radiation-induced intraspinal Schwann cells extend misdirected processes into the dorsal root.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
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Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.