PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth, and myelination.
Mark H. Tuszynski,Mark H. Tuszynski,Norbert Weidner,Melissa McCormack,Ian Miller,Henry C. Powell,James M. Conner +6 more
TL;DR: It is demonstrated that primary adult Schwann cells can be transduced to secrete augmented levels of neurotrophic factors and survive grafting to the CNS for prolonged time periods, and elicit robust growth of host neurotrophin-responsive axons.
Journal ArticleDOI
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling
Bogdan Beirowski,Jason A. Gustin,Sean M. Armour,Hiroyasu Yamamoto,Andreu Viader,Brian J. North,Shaday Michan,Robert H. Baloh,Judy P. Golden,Robert E. Schmidt,David A. Sinclair,Johan Auwerx,Jeffrey Milbrandt +12 more
TL;DR: It is shown that Sirt2 expression in SCs is correlated with that of structural myelin components during both developmental myelination and remyelination after nerve injury, and insights into the association between intracellular metabolism and SC plasticity are provided.
Journal ArticleDOI
Division of Labor of Schwann Cell Integrins during Migration on Peripheral Nerve Extracellular Matrix Ligands
Richard Milner,Martin J. Wilby,Stephen L. Nishimura,Kevin Boylen,Gwynneth M. Edwards,James W. Fawcett,Charles H. Streuli,Robert Pytela,Charles ffrench-Constant +8 more
TL;DR: There is a division of labor of Schwann cell Integrins in the regulation of migration on peripheral nerve ECM components; beta1 integrins mediate migration on laminin-1 and lamin in-2 (merosin), while alpha v integrin mediate Migration on fibronectin.
Journal ArticleDOI
Macrophage expression in endometrium of women with and without endometriosis
TL;DR: This study further supports an association between immune changes in eutopic endometrium and presence of endometriosis, however, it remains uncertain if eUTopic immune changes are primary or secondary occurrences.
Journal ArticleDOI
Biomaterials that regulate growth factor activity via bioinspired interactions.
TL;DR: A detailed overview of the various bioinspired strategies that are used to noncovalently localize growth factor activity within biomaterials are provided, and in vivo examples of the efficacy of these materials to promote tissue regeneration are highlighted.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.