PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
T. Herdegen,J.D. Leah +1 more
TL;DR: This article reviews findings up to the end of 1997 about the inducible transcription factors c-Jun, JunB, JunD, c-Fos, FosB, Fra,1, Fra-2, Krox-20 (Egr-2) and Krox -24 (NGFI-A, Egr-1, Zif268) as they pertain to gene expression in the mammalian nervous system and describes their expression and possible roles in glial cells.
Journal ArticleDOI
The cellular and molecular basis of peripheral nerve regeneration.
Susan Y. Fu,Tessa Gordon +1 more
TL;DR: Axonal regeneration may be facilitated by new strategies that enhance the growth potential of neurons and optimize the growth support of the distal nerve stump in combination with prompt nerve repair.
Journal ArticleDOI
A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration
TL;DR: It is demonstrated that the myelin-associated glycoprotein (MAG), a transmembrane protein of both CNS and PNS myelin, strongly inhibits neurite outgrowth from both developing cerebellar and adult dorsal root ganglion (DRG) neurons in vitro and is reversed by an anti-MAG antibody.
Journal ArticleDOI
Neural plasticity after peripheral nerve injury and regeneration.
TL;DR: An important direction for ongoing research is the development of therapeutic strategies that enhance axonal regeneration, promote selective target reinnervation, but are also able to modulate central nervous system reorganization, amplifying those positive adaptive changes that help to improve functional recovery but also diminishing undesirable consequences.
Journal ArticleDOI
Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.
Mark A. Marchionni,Andrew Goodearl,Maio Su Chen,Olivia Bermingham-McDonogh,Cassandra Kirk,Marvin Hendricks,Frank Danehy,Don Misumi,Judith Sudhalter,Kazumi Kobayashi,Diana Wroblewski,Catherine Lynch,Mark Baldassare,Ian Hiles,John B. Davis,John B. Davis,J. Justin Hsuan,Nicholas F. Totty,Masayuki Otsu,Robert N. McBurney,Michael D. Waterfield,Paul Stroobant,David I. Gwynne +22 more
TL;DR: Alternative splicing of the messenger RNA generates an array of putative membrane-attached, intracellular and secreted signalling proteins, at least some of which are expressed in the developing spinal cord and brain.
References
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Journal ArticleDOI
Nerve regeneration through the basal lamina scaffold of the skeletal muscle
TL;DR: Findings show that basal lamina scaffolds of muscle cells provide a proper microenvironment for the growth of regenerating nerve fibers in the region near the proximal end of the graft.
Patent
Prostheses and methods for promoting nerve regeneration
TL;DR: In this paper, the proximal and distal ends of a severed nerve are brought into close proximity and are enclosed by a tubular prosthesis, where a tight seal is formed between the prosthesis and the injured nerve so as to isolate the injured node from the rest of the body of the host.
Journal ArticleDOI
A morphological study on the effects of collagen gel matrix on regeneration of severed rat sciatic nerve in silicone tubes.
Takao Satou,Shozo Nishida,Shingo Hiruma,Kurenai Tanji,Manabu Takahashi,Shuichiro Fujita,Yasuharu Mizuhara,Fumiharu Akai,Shigeo Hashimoto +8 more
TL;DR: The result indicates that regeneration of the peripheral nerves in the silicone tube can be improved, by using appropriate exogenous fine materials, collagen matrix.