PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Células-tronco da medula óssea e do tecido adiposo na regeneração do nervo ulnar em equinos
TL;DR: In this paper, a mesmo procedimento cirurgia em todos os grupos, utilizando-se os dois nervos de cada animal (direito e esquerdo), and estabelecido dois momentos of biopsia: na 13a semana with biopsias no membro direiro (GC1, FCM1, and ADSC1) and na 26a semanária with histology at the same level (GC2, FGF-2, etc.).
Book ChapterDOI
Electrophysiological characteristics of injured peripheral nerves
TL;DR: Patients with peripheral nerve lesions should complain of sensory deficits following injury because it is the peripheral, receptive ending that is the only part of the sensory neuron specialised for action potential generation under normal conditions.
Journal ArticleDOI
Differential display cloning of genes induced in regenerating neurons.
Frederick J. Livesey,SP Hunt +1 more
TL;DR: The single-base anchor method of mRNA differential display was used to study changes in gene expression in regenerating adult mammalian sensory neurons and two genes, LA12.2 and LC12, were definitively confirmed as induced in Regenerating neurons.
Journal ArticleDOI
Non-neuronal cells are not the limiting factor for the low axonal regeneration in C57BL/6J mice.
TL;DR: The hypothesis that the non-neuronal cells, mainly Schwann cells, present in the sciatic nerve of C57BL/6J mice are not the main limiting factor responsible for low axonal regeneration is supported.
Journal ArticleDOI
Transcription initiation factor IIB involves in Schwann cell differentiation after rat sciatic nerve crush
Jiao Yang,Jianhua Cao,Youhua Wang,Jian Xu,Zhengming Zhou,Xingxing Gu,Xiaojuan Liu,Hai Wen,Hao Wu,Chun Cheng +9 more
TL;DR: Peripheral nerve crush-induced upregulation of TFIIB in the sciatic nerve was associated with Schwann cell differentiation and in vitro,TFIIB-specific siRNA inhibited cAMP-induced Schwanncell morphological change and the expression of P0.0.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.