PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
6-Sulphated Chondroitins Have a Positive Influence on Axonal Regeneration
TL;DR: The results suggest that the upregulation of 6-sulphated GAG after injury makes the extracellular matrix more permissive for axon regeneration, and that the balance of different CSs in the microenvironment around the lesion site is an important factor in determining the outcome of nervous system injury.
Journal ArticleDOI
Differential Regulation of Calcitonin Gene-related Peptide (CGRP) in Regenerating Rat Facial Nucleus and Dorsal Root Ganglion.
TL;DR: Axotomy leads to a differential regulation of both CGRP and C GRP‐mRNA in regenerating facial motor nucleus and sensory L5 DRG, and no recovery to normal levels is seen for either peptide or mRNA levels in Regenerating DRG up to 45 days after injury.
Journal ArticleDOI
Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy
Hidenori Horie,Toshihiko Kadoya,Naoshi Hikawa,Kazunori Sango,Hiroko Inoue,Kaori Takeshita,Reiko Asawa,Tomoko Hiroi,Manami Sato,Tohru Yoshioka,Yoshihiro Ishikawa +10 more
TL;DR: It is proposed that axonal regeneration occurs in axotomized peripheral nerves as a result of cytosolic reduced galectin-1 being released from Schwann cells and injured axons, which then becomes oxidized in the extracellular space.
Journal ArticleDOI
Myelin-associated glycoprotein: a role in myelination and in the inhibition of axonal regeneration?
TL;DR: MAG knockout mice reveal that MAG is not essential for the initiation of myelination; however, it plays an important role in maintaining a stable interaction between axons and myelin.
Journal ArticleDOI
Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor.
V. Pignot,Andreas Hein,Carmen Barske,Christoph Wiessner,Adrian R. Walmsley,Klemens Kaupmann,H. Mayeur,Bernd Sommer,Anis Mir,Stefan Frentzel +9 more
TL;DR: The data indicate that NgR, NgRH1 and NgRH2 constitute a novel receptor protein family, which may play related roles within the CNS.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.