PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Peri̇feri̇k si̇ni̇r yaralanmalari, rejenerasyonu ve tedavi̇ seçenekleri̇
TL;DR: In this paper , periferik sinirlerde oluşabilecek hasar kişinin motor ve duyu uyarımını olumsuz etkilemektedir, ayrıca rejenerasyona etki eden nörotrofik faktörler ve tedavi sürecinde kullanılan farklı metotların etki mekanizmalarna değinilmiştir.
Temporal-Spatial Expressions of Spy1 in Rat Sciatic Nerve After Crush
TL;DR: In this article, the role of Spy1 in the pathological process of damage and regeneration of the peripheral nervous system was examined in a rat sciatic nerve crush (SNC) model to examine the spatiotemporal expression of spy1.
Dissertation
The Role of Interleukin-10 in CD4+ T Cell-Mediated Neuroprotection after Facial Nerve Injury
Book ChapterDOI
History of Peripheral Nerve Repair
TL;DR: Throughout its history, the field has worked to determine the classification of nerve injuries, whether these injuries should be operated upon or not, which procedure should be undertaken if operation is decided on, which techniques were best for nerve suture if undertaken, how to deal with nerve gaps if they are too large for direct suture, and timing of surgery.
Dissertation
Nerve regeneration through autologous grafts: exploring the 'Bottleneck Theory' further
TL;DR: The hypothesis being tested was that nerve grafts with a higher axonal count would yield better outcomes than those with lower axonal counts, and it was demonstrated that larger grafts produced better clinical outcomes of ear movement and a higher number of axons regenerated across the graft.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.