PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Book ChapterDOI
A Preliminary Study on Spider Silk as Biomaterial for Peripheral Nerve Regeneration
Stephanie Bruns,Yvonne Stark,Dana Marten,C. Allmeling,Cornelia Kasper,Frank Stahl,Thomas Scheper +6 more
TL;DR: In this paper, the cytotoxicity, viability, and proliferation of the cell lines growing on the spider silk strands were investigated and morphology of cell settling and spreading of the cells on the strands were observed by means of confocal and SEM micrographs.
Journal ArticleDOI
Morphometric changes in free neurovascular latissimus dorsi flaps: An experimental study
TL;DR: This study used a rat model, consisting of eight rats per group, in which the latissimus dorsi muscle was transplanted orthotopically and then harvested and evaluated after 2 and 12 weeks to investigate regeneration of reinnervated, free transplanted muscles.
Journal ArticleDOI
Repair of injured fiber tracts in the mammalian central nervous system
TL;DR: Antibodies that neutralize one of the most potent inhibitory constituents, Nogo-A, allow long-distance re-growth of injured axons in the rat and macaque spinal cord after injury, as well as enhanced compensatory growth of spared fiber tracts.
Contributions of Monoclonal Antibodies With Anti-Neural Cell Adhesion Molecule Like Activity to Peripheral Nerve Regeneration.
TL;DR: It is proposed that perturbed Schwann cell adhesive interactions disrupted the advance of neurites across nerve gaps and resulted in delayed regeneration, implicated N-CAM as a potential contributor to nerve regeneration.
Journal ArticleDOI
Reinnervation of rat endometrium in the anterior eye chamber model of experimental endometriosis: Old methods for new questions.
TL;DR: The results suggest that the rat endometrium possesses intrinsic neuritogenic capacities and can be reinnervated by sympathetic and sensory nerves in ectopic sites different from the peritoneum.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.