PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Regeneration of axons after nerve transection repair is enhanced by degradation of chondroitin sulfate proteoglycan.
TL;DR: It is concluded that growth inhibition by CSPG contributes critically to the poor regenerative growth of axons in nerve transection repair and chondroitinase application may be used clinically to improve the outcome of primary peripheral nerve repair.
Journal ArticleDOI
Biofabrication and testing of a fully cellular nerve graft
TL;DR: A novel approach to biofabricate fully biological grafts composed exclusively of cells and cell secreted material is reported on, providing evidence that bioprinting is a promising approach to nerve graft fabrication and as a consequence to nerve regeneration.
Journal ArticleDOI
Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat.
TL;DR: Observations suggest that ERK activation is important in the establishment of a regeneration-promoting extracellular environment in the far distal stump of transected nerves and that STAT3 activation isimportant in the control of cellular responses close to the site of injury.
Journal ArticleDOI
Reinnervation Accuracy of the Rat Femoral Nerve by Motor and Sensory Neurons
TL;DR: The results confirm previous observations concerning preferential motor reinnervation for motorneurons, and show for the first time anatomical evidence of specificity during regeneration of sensory afferent projections to muscle, as well as highly correlated with the accuracy of motor regeneration.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.