PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
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Patent
Method of forming fibrin-collagen nerve and body tissue repair material
TL;DR: In this article, a method of forming material including alternating layers of fibrin and collagen, formed into tubes, is disclosed for use in repairing transected nerve fibers either by tubulization of the approximated nerve ends, or as an artificial graft which are placed in the severed ends of the nerve, for promotion of nerve growth and regeneration.
Journal ArticleDOI
Postnatal development of 5-HT1A receptor expression in rat somatic motoneurons
TL;DR: In this article, it was shown that motoneuronal afferent (serotonergic) and efferent (neuromuscular) innervation of the hypoglossal nucleus (nXII) was disrupted in neonatal rats by intra-cisternal injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5, 7-DHT), and 5-HT(1A) receptor mRNA levels in nXII from these rats were assayed at postnatal day 21.
Journal ArticleDOI
A novel experimental rat model of peripheral nerve scarring that reliably mimics post-surgical complications and recurring adhesions.
Angela Lemke,Carina Penzenstadler,James Ferguson,Dominika Lidinsky,Rudolf Hopf,Monika Bradl,Heinz Redl,Susanne Wolbank,Thomas Hausner +8 more
TL;DR: A reliable rat model that exhibits the essential pathological processes of peripheral nerve scarring is developed and could, for the first time, demonstrate not only the primary formation, but also the recurrence, of severe adhesions 1 week after glue removal, imitating a major clinical challenge.
Journal ArticleDOI
Study of biocompatibility of small intestinal submucosa (SIS) with Schwann cells in vitro.
TL;DR: SIS has a good biocompatibility with SCs and SIS pre-seeded withSCs has potential to be an alternate candidate of autografting for repairing long peripheral nerve defects.
Journal ArticleDOI
Co-induction of nitric oxide synthase, Bcl-2 and growth-associated protein-43 in spinal motoneurons during axon regeneration in the lizard tail.
TL;DR: Investigating whether the cell death repressor Bcl-2 protein and growth-associated protein-43 (GAP-43) were also induced in motoneurons that innervate the regenerated tail in the first month post-caudotomy demonstrated that co-induction of nitric oxide synthase, B cl-2 and Gap-43 may be part of the molecular repertoire of injured motoneURons committed to survival and axon regeneration.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
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Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.