PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
More filters
Book ChapterDOI
Pathophysiology of Peripheral Nerve Injury
TL;DR: The PNS consists of a complex arborisation of peripheral nerves, which consists of nerve fibres and supportive connective tissue, which serves dual purpose of disseminating information from the central nervous systems and ensuring that this information is interpreted to the target end organs.
Journal ArticleDOI
Schwann Cells Migration on Patterned Polydimethylsiloxane Microgrooved Surface.
TL;DR: A large population of migrating SCs are investigated over a period of 2 weeks on patterned polydimethylsiloxane microgrooved channels of different sizes to understand the migration of large populations of SC and the collective guidance cues from the surrounding environment in designing optimal transplantable scaffolds.
Journal ArticleDOI
Peripheral Nerve Injury
TL;DR: Current tends in surgical management and nerve growth enhancement and a review of research relevant to rehabilitation concepts that illustrates the role of physiotherapist in the management of nerve injuries and repairs are discussed.
Journal ArticleDOI
Antibodies to interleukin-6 inhibit Schwann cell proliferation induced by unfractionated cytokines
Robert P. Lisak,Beverly Bealmear +1 more
TL;DR: Interleukin-6 is a co-mitogen for neonatal Schwann cells in vitro and addition of excess rhIL-6 to a mixture of unfractionated cytokines plus anti-rhIL- 6 abrogated the inhibitory effect of theAnti-rhil-6.
Journal ArticleDOI
Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus
Jon P. Niemi,Angela R. Filous,Alicia DeFrancesco,Jane A. Lindborg,Nisha A. Malhotra,Gina N. Wilson,Bowen Zhou,Samuel D. Crish,Richard E. Zigmond +8 more
TL;DR: A novel mechanism for the decreased response of diabetic sympathetic and sensory neurons to injury is suggested, including decreased induction of several gp130‐dependent RAGs, including galanin and vasoactive intestinal peptide.
References
More filters
Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.