PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
The dynamics of axolemmal disruption in guinea pig spinal cord following compression.
TL;DR: It is shown that membrane damage exists days, and possibly weeks, after spinal cord trauma in live guinea pigs, and a long therapeutical window for membrane repair and functional enhancement following traumatic injury in the central nervous system is revealed.
Journal ArticleDOI
An NF-kappaB-like transcription factor in axoplasm is rapidly inactivated after nerve injury in Aplysia.
TL;DR: A protein in Aplysia neurons that has many characteristics of the transcription factor NF-κB is believed to be a homolog of NF-π, and the role of apNF-β in the axon is investigated.
Journal ArticleDOI
Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System.
Alois Hopf,Alois Hopf,Dirk J. Schaefer,Daniel F. Kalbermatten,Daniel F. Kalbermatten,Raphael Guzman,Srinivas Madduri,Srinivas Madduri +7 more
TL;DR: The present review accounts for current developments in the field of SCLC differentiation, their applications in peripheral and central nervous system injury, and provides insights for future strategies.
Journal ArticleDOI
Axonal Regeneration after Sciatic Nerve Lesion Is Delayed but Complete in GFAP- and Vimentin-Deficient Mice
Alexander Berg,Johan Zelano,Marcela Pekna,Marcela Pekna,Ulrika Wilhelmsson,Milos Pekny,Milos Pekny,Staffan Cullheim +7 more
TL;DR: The absence of GFAP and vimentin in glial cells does not seem to affect the outcome after peripheral motoneuron injury but may have an important effect on the response dynamics.
Journal ArticleDOI
Ginsenoside Re Promotes Nerve Regeneration by Facilitating the Proliferation, Differentiation and Migration of Schwann Cells via the ERK- and JNK-Dependent Pathway in Rat Model of Sciatic Nerve Crush Injury
TL;DR: Investigation of the protect effect of Re on peripheral nerve regeneration in a rat SNC model revealed that Re treatment significantly promoted functional recovery of crushed sciatic nerve in rats, and studies reveal that Re promotes nerve regeneration is depend on ERK1/2 and JNK1-2 signaling pathway.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.