PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Time sequence of auditory nerve and spiral ganglion cell degeneration following chronic kanamycin-induced deafness in the guinea pig
TL;DR: The effects of kanamycin on hair cells, spiral ganglion cell and Schwann cells are progressive and multiple factors such as loss of hair cell, degeneration of Schwann cell and the progressive damage of Kanamycin, may participate in the late degeneration process of SGCs.
Book ChapterDOI
Schwann Cell Development
Kristjan R. Jessen,Rhona Mirsky +1 more
TL;DR: In this paper, the development of glial cells in early neonatal nerve trunks of rodents is described, and the origin of the Schwann cell lineage and the cellular transformations that lead to the appearance of immature Schwann cells, the predominant glial cell in rodent nerves at birth.
Journal ArticleDOI
Peripheral target reinnervation following orthotopic grafting of fetal allogeneic and xenogeneic dorsal root ganglia
TL;DR: The consistent finding of immunolabeled axons ending free and in encapsulated structures in the target tissues of both allo- and xenografted rats indicates that grafted primary sensory neurons can survive and send axonal processes down the full length of the hind limb, to terminate in host target tissues.
Journal ArticleDOI
In vitro pre-degenerated nerve autografts support CNS axonal regeneration.
TL;DR: The axonal regeneration of central respiratory neurons within autologous fresh and pre-degenerated peripheral nerve grafts (PNGs) implanted within the C2 cervical spinal spinal cord was studied by recording spontaneous unit activity as mentioned in this paper.
Patent
Vascular grafts derived from acellular tissue matrices
TL;DR: In this paper, a vascular graft for treatment of diseased or damaged blood vessels is disclosed, which comprises a sheet of acellular tissue matrix with an intact basement membrane, formed by wrapping the sheet into a tube and securing the edges of the sheet together.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.