PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Histological rearrangement in the facial nerve and central nuclei following immediate and delayed hypoglossal-facial nerve anastomosis.
TL;DR: Immediate anastomosis resulted in better nerve regeneration of the facial nerve, but the numbers of surviving neurons in the facial and hypoglossal nuclei were almost the same in both the immediate and delayed anastOMosis groups.
Journal ArticleDOI
The combination of peripheral nerve grafts and acidic fibroblast growth factor enhances arginase I and polyamine spermine expression in transected rat spinal cords.
Huai-Sheng Kuo,May J. Tsai,Ming-Chao Huang,Ming-Chao Huang,Wen Cheng Huang,Wen Cheng Huang,Meng-Jen Lee,Meng-Jen Lee,Wen-Chun Kuo,Li-Hua You,Ka-Chun Szeto,I-Lun Tsai,Wen Chi Chang,Chuan-Wen Chiu,Hsu Ma,Kin-Fu Chak,Henrich Cheng +16 more
TL;DR: In addition to enhancing the expression of Arg I and spermine in repaired spinal cords, the treatment may recruit activated macrophages and create a more favorable environment for axonal regrowth.
Journal ArticleDOI
Neurotrophin-4/5 is implicated in the enhancement of axon regeneration produced by treadmill training following peripheral nerve injury.
TL;DR: The effects of treadmill training on axon regeneration in cut peripheral nerves are independent of changes produced in the distal segment of the cut nerve and depend on the promotion of axon Regeneration by changes in NT‐4/5 expression by cells in the proximal nerve segment.
Journal ArticleDOI
Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration.
Yung Ming Chang,Hen-Hong Chang,Chin Chuan Tsai,Hung-Jen Lin,Tsung Jung Ho,Chi Xin Ye,Ping Ling Chiu,Yueh-Sheng Chen,Ray Jade Chen,Chih Yang Huang,Chih Yang Huang,Chien Chung Lin +11 more
TL;DR: Positive results are provided that demonstrate that Alpinia oxyphylla Miq.
Journal ArticleDOI
Sr13/pmp-22 expression in rat nervous system, in pc12 cells and c6 glial cell lines
TL;DR: The experiments suggest that SR13/PMP‐22 may have some other function(s) in addition to its hypothesized role in peripheral myelination.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.