PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Two novel monoclonal antibodies (1.9.E and 4.11.C) against olfactory bulb ensheathing glia
M. Heredia,J. Gascuel,Almudena Ramón-Cueto,Maria Santacana,Jesús Avila,C. Masson,Facundo Valverde +6 more
TL;DR: Two monoclonal antibodies produced and characterized suggest that both antibodies are specific markers for olfactory ensheathing glia in the adult rat central nervous system (CNS).
Journal ArticleDOI
Effects of cerebrolysin on rat Schwann cells in vitro.
TL;DR: It is suggested that cerebrolysin may be suitable for therapeutic usage to enhance PNS regeneration/reconstruction by enhancing the functions of SCs that are relevant to nerve regeneration.
Journal ArticleDOI
In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft
TL;DR: Although neuroregeneration is detected in PHO grafts with minor degradation in 60 d, autologous nerve graft is found to be superior in axonal regeneration compared to PHO nerve tube grafts.
Journal ArticleDOI
Nerve regeneration: might this be the only solution for functional problems of the urinary tract?
Suzanne Biers,Alison F. Brading +1 more
TL;DR: These revolutionary technologies may, in the future, provide a means of treating urinary tract dysfunction with some types of aetiology, including acute spinal cord injury, and injury to nerves following pelvic surgery.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.