PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TLDR
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.Abstract:
Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina. When connected to nerve stumps the basal lamina surfaces promote axon regeneration therethrough, eventually reestablishing nerve function through the regenerated graft.read more
Citations
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Journal ArticleDOI
Immunohistological Localization of Tenascin in the Developing and Lesioned Adult Mouse Optic Nerve.
TL;DR: It is concluded that tenascin in the optic nerve is synthesized by glial cells and not by retinal ganglion cells, which suggests that it may mediate neurite growth in vivo.
Journal ArticleDOI
Reciprocal signaling between spiral ganglion neurons and Schwann cells involves neuregulin and neurotrophins.
TL;DR: Neuregulin and neurotrophins may mediate reciprocal neuron-glial interactions in the auditory nerve by regulating proliferation and/or neurotrophin expression in spiral ganglion Schwann cells.
Journal ArticleDOI
The Role of Schwann Cell-Axon Interaction in Peripheral Nerve Regeneration
TL;DR: Comparing with the role of Schwann cells in developing nerves, this review is focused on cellular and molecular aspects of SchwANN cell interaction with axons at the early stages of regeneration.
Journal ArticleDOI
A role for insulin-like growth factor-I in the regulation of Schwann cell survival.
Daniel E. Syroid,Todd S. Zorick,Christophe Arbet-Engels,Trevor J. Kilpatrick,Walter Eckhart,Greg Lemke +5 more
TL;DR: Insulin-like growth factor-I (IGF-I) is identified as an additional trophin that can promote Schwann cell survivalin vitro and it is found that IGF-I, like NRG-1, can prevent the apoptotic death of postnatal rat Schwann cells cultured under conditions of serum withdrawal.
Journal ArticleDOI
Purification of multiple forms of glial growth factor.
A. D. J. Goodearl,John B. Davis,K. Mistry,Luisa Minghetti,Masayuki Otsu,Mike Waterfield,Paul Stroobant +6 more
TL;DR: The GGFs, which contain N-linked carbohydrate groups not essential for their in vitro mitogenic effects, are three distinct members of a novel family of glial cell mitogens that share a similar dose-dependent stimulation of Schwann cell DNA synthesis at nanomolar concentrations.
References
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Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Structural characterization and biological functions of fibroblast growth factor
TL;DR: As expected from their structural relationship, both FGF and aFGF interact with the same receptor (7), thereby having similar, if not identical, properties.
Journal ArticleDOI
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
TL;DR: In situ hybridization experiments demonstrated that after transection all nonneuronal cells express mRNANGF and not only those ensheathing the nerve fibers of NGF-responsive neurons, and the volume is too small to fully replace the lacking supply from the periphery.
Journal ArticleDOI
Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
TL;DR: The object of the present observations is to describe certain alterations which take place in the elementary fibres of the nerve after they have been removed from their connection with the brain or spinal marrow.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.