Journal ArticleDOI
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Masao Tanaka,Carlos Fernandez-del Castillo,Terumi Kamisawa,Jin-Young Jang,Philippe Lévy,Takao Ohtsuka,Roberto Salvia,Yasuhiro Shimizu,Minoru Tada,Christopher L. Wolfgang +9 more
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TLDR
The working group has revised the guidelines regarding prediction of invasive carcinoma and high-grade dysplasia, surveillance, and postoperative follow-up of IPMN and includes updated information and recommendations based on the current understanding.About:
This article is published in Pancreatology.The article was published on 2017-09-01. It has received 1104 citations till now.read more
Citations
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Journal ArticleDOI
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes
Andrew J McGuigan,Paul Kelly,Richard C. Turkington,C. Jones,Helen G. Coleman,R Stephen McCain +5 more
TL;DR: This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy.
Journal ArticleDOI
European evidence-based guidelines on pancreatic cystic neoplasms
Marco Del Chiaro,Marc G. Besselink,Lianne Scholten,Marco J. Bruno,Djuna L. Cahen,Thomas M. Gress,Jeanin E. van Hooft,Markus M. Lerch,Julia Mayerle,Thilo Hackert,Sohei Satoi,Alessandro Zerbi,David Cunningham,Claudio De Angelis,Marc Giovanni,Enrique de-Madaria,Péter Hegyi,Jonas Rosendahl,Helmut Friess,Riccardo Manfredi,Philippe Lévy,Francisco X. Real,Alain Sauvanet,Mohammed Abu Hilal,Giovanni Marchegiani,Irene Esposito,Paula Ghaneh,Marc R. W. Engelbrecht,Paul Fockens,Nadine C.M. van Huijgevoort,Christopher L. Wolfgang,Claudio Bassi,Natalya Gubergrits,Caroline S. Verbeke,Günter Klöppel,Aldo Scarpa,Giuseppe Zamboni,Anne Marie Lennon,Malin Sund,Nikolaos Kartalis,Lars Grenacher,Massimo Falconi,Urban Arnelo,Kostantin V. Kopchak,Kofi Oppong,Colin J. McKay,Truls Hauge,Kevin C. Conlon,Mustapha Adham,Güralp O. Ceyhan,Roberto Salvia,Christos Dervenis,Peter J. Allen,François Paye,Detlef K. Bartsch,Matthias Löhr,Massimiliano Mutignani,Johanna Laukkarinen,Richard D. Schulick,Roberto Valente,Thomas Seufferlein,Gabriele Capurso,Ajith K. Siriwardena,John P. Neoptolemos,Aldis Pukitis,Ralf Segersvärd,Ali A. Aghdassi,Stefano Andrianello,Peter Bossuyt,Robin Bülow,Karina Cárdenas-Jaén,P. Cortegoso,Martina Fontana,Lena Haeberle,M. Heckler,Andrey Litvin,Kulbir Mann,Christoph W. Michalski,Patrick Michl,Gennaro Nappo,Giampaolo Perri,S. Persson,F. Scheufele,Francesco Sclafani,Manuel Schmidt,L. Venezia,F. Volker,M-P Vullierm,L. Wusten +88 more
TL;DR: A conservative approach is recommended for asymptomatic MCN and IPMN, and Lifelong follow-up of IPMN is recommended in patients who are fit for surgery.
Journal ArticleDOI
Pancreatic adenocarcinoma, Version 2.2021
Margaret A. Tempero,Mokenge P. Malafa,Mahmoud M. Al-Hawary,Stephen W. Behrman,Al B. Benson,Dana Backlund Cardin,E. Gabriela Chiorean,Vincent Chung,Brian G. Czito,Marco Del Chiaro,Mary Dillhoff,Timothy R. Donahue,Efrat Dotan,Cristina R. Ferrone,Christos Fountzilas,Jeffrey M. Hardacre,William G. Hawkins,Kelsey Klute,Andrew H. Ko,John W. Kunstman,Noelle K. LoConte,Andrew M. Lowy,Cassadie Moravek,Eric K. Nakakura,Amol Narang,Jorge Obando,Patricio M. Polanco,Sushanth Reddy,Marsha Reyngold,Courtney L. Scaife,Jeanne Shen,Charles M. Vollmer,Robert A. Wolff,Brian M. Wolpin,Beth Lynn,Giby V. George +35 more
Abstract: Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcinoma provides recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pancreatic cancer. Although survival rates remain relatively unchanged, newer modalities of treatment, including targeted therapies, provide hope for improving patient outcomes. Sections of the manuscript have been updated to be concordant with the most recent update to the guidelines. This manuscript focuses on the available systemic therapy approaches, specifically the treatment options for locally advanced and metastatic disease.
Journal ArticleDOI
Early Detection of Pancreatic Cancer: Opportunities and Challenges
TL;DR: Current and emerging imaging modalities that are critical to identifying early, potentially curable PDAC in high-risk cohorts on surveillance are discussed.
Journal ArticleDOI
Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression.
Vincent Bernard,Alexander Semaan,Jonathan Huang,F. Anthony San Lucas,Feven C Mulu,Bret M. Stephens,Paola A. Guerrero,Yanqing Huang,Jun Zhao,Nabiollah Kamyabi,Subrata Sen,Paul Scheet,Cullen M. Taniguchi,Michael P. Kim,Ching Wei D. Tzeng,Matthew Harold Katz,Aatur D. Singhi,Anirban Maitra,Hector A Alvarez +18 more
TL;DR: The ability to perform high-resolution profiling of the transcriptomic changes that occur during multistep progression of cystic PDAC precursors to cancer is demonstrated and might be a useful substrate to identify targets for cancer interception.
References
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Journal ArticleDOI
Intraductal Oncocytic Papillary Neoplasms of the Pancreas.
Michael E. Kallen,Bita V. Naini +1 more
TL;DR: Features of pancreatic IOPNs are reviewed, differential diagnosis of other intraductal lesions in the pancreas is discussed, and there are limited data regarding the clinical behavior and prognosis of IOPs in comparison to other subtypes of IPMN.
Journal ArticleDOI
Mural nodule of 10 mm or larger as predictor of malignancy for intraductal papillary mucinous neoplasm of the pancreas: Pathological and radiological evaluations
Natsuko Kawada,Hiroyuki Uehara,Shigenori Nagata,Mutsumi Tsuchishima,Mikihiro Tsutsumi,Yasuhiko Tomita +5 more
TL;DR: Detectability of MN ≥ 10 mm is excellent in US and EUS and HGD is located only in low papillary epithelia around MN in the remaining 30%, in which sensitivity of pancreatic juice cytology is shown to be inadequate.
Journal ArticleDOI
High expression of intestinal-type mucin (MUC2) in intraductal papillary mucinous neoplasms coexisting with extrapancreatic gastrointestinal cancers.
Sun-Young Lee,Dong Wook Choi,Kee-Taek Jang,Kyu Taek Lee,Seong-Ho Choi,Jin Seok Heo,Jong Kyun Lee,Seung Woon Paik,Jong Chul Rhee +8 more
TL;DR: Regardless of the subtypes of papillae, transcription of the MUC2 might be related with the synchronous extrapancreatic gastrointestinal cancer development that is seen with IPMN, therefore, careful systemic surveillance is needed to detect coexisting gastrointestinal cancer for all the sub types of IPMN with M UC2 expression.
Journal ArticleDOI
Distinction of Invasive Carcinoma Derived From Intraductal Papillary Mucinous Neoplasms From Concomitant Ductal Adenocarcinoma of the Pancreas Using Molecular Biomarkers.
Koji Tamura,Takao Ohtsuka,Kenjiro Date,Takaaki Fujimoto,Taketo Matsunaga,Hideyo Kimura,Yusuke Watanabe,Tetsuyuki Miyazaki,Kenoki Ohuchida,Shunichi Takahata,Kousei Ishigami,Yoshinao Oda,Kazuhiro Mizumoto,Masafumi Nakamura,Masao Tanaka +14 more
TL;DR: It may be possible to distinguish Inv-IPMN from concomitant PDAC by assessing these molecular biomarkers, and this will lead to adequate recognition of the natural history of IPMNs and hence optimal management.
Journal ArticleDOI
Intraductal papillary mucinous neoplasms of the pancreas with concurrent pancreatic and periampullary neoplasms
Klaus Sahora,Stefano Crippa,Giuseppe Zamboni,Cristina R. Ferrone,Andrew L. Warshaw,Keith D. Lillemoe,Mari Mino-Kenudson,Massimo Falconi,C. Fernandez-del Castillo +8 more
TL;DR: IPN, mainly BD-IPMN, are associated with con-PDAC in about 7% of patients and account for 62% of all concurrent pancreatic/ampullary neoplasms.
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