Journal ArticleDOI
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Masao Tanaka,Carlos Fernandez-del Castillo,Terumi Kamisawa,Jin-Young Jang,Philippe Lévy,Takao Ohtsuka,Roberto Salvia,Yasuhiro Shimizu,Minoru Tada,Christopher L. Wolfgang +9 more
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TLDR
The working group has revised the guidelines regarding prediction of invasive carcinoma and high-grade dysplasia, surveillance, and postoperative follow-up of IPMN and includes updated information and recommendations based on the current understanding.About:
This article is published in Pancreatology.The article was published on 2017-09-01. It has received 1104 citations till now.read more
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Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes
Andrew J McGuigan,Paul Kelly,Richard C. Turkington,C. Jones,Helen G. Coleman,R Stephen McCain +5 more
TL;DR: This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy.
Journal ArticleDOI
European evidence-based guidelines on pancreatic cystic neoplasms
Marco Del Chiaro,Marc G. Besselink,Lianne Scholten,Marco J. Bruno,Djuna L. Cahen,Thomas M. Gress,Jeanin E. van Hooft,Markus M. Lerch,Julia Mayerle,Thilo Hackert,Sohei Satoi,Alessandro Zerbi,David Cunningham,Claudio De Angelis,Marc Giovanni,Enrique de-Madaria,Péter Hegyi,Jonas Rosendahl,Helmut Friess,Riccardo Manfredi,Philippe Lévy,Francisco X. Real,Alain Sauvanet,Mohammed Abu Hilal,Giovanni Marchegiani,Irene Esposito,Paula Ghaneh,Marc R. W. Engelbrecht,Paul Fockens,Nadine C.M. van Huijgevoort,Christopher L. Wolfgang,Claudio Bassi,Natalya Gubergrits,Caroline S. Verbeke,Günter Klöppel,Aldo Scarpa,Giuseppe Zamboni,Anne Marie Lennon,Malin Sund,Nikolaos Kartalis,Lars Grenacher,Massimo Falconi,Urban Arnelo,Kostantin V. Kopchak,Kofi Oppong,Colin J. McKay,Truls Hauge,Kevin C. Conlon,Mustapha Adham,Güralp O. Ceyhan,Roberto Salvia,Christos Dervenis,Peter J. Allen,François Paye,Detlef K. Bartsch,Matthias Löhr,Massimiliano Mutignani,Johanna Laukkarinen,Richard D. Schulick,Roberto Valente,Thomas Seufferlein,Gabriele Capurso,Ajith K. Siriwardena,John P. Neoptolemos,Aldis Pukitis,Ralf Segersvärd,Ali A. Aghdassi,Stefano Andrianello,Peter Bossuyt,Robin Bülow,Karina Cárdenas-Jaén,P. Cortegoso,Martina Fontana,Lena Haeberle,M. Heckler,Andrey Litvin,Kulbir Mann,Christoph W. Michalski,Patrick Michl,Gennaro Nappo,Giampaolo Perri,S. Persson,F. Scheufele,Francesco Sclafani,Manuel Schmidt,L. Venezia,F. Volker,M-P Vullierm,L. Wusten +88 more
TL;DR: A conservative approach is recommended for asymptomatic MCN and IPMN, and Lifelong follow-up of IPMN is recommended in patients who are fit for surgery.
Journal ArticleDOI
Pancreatic adenocarcinoma, Version 2.2021
Margaret A. Tempero,Mokenge P. Malafa,Mahmoud M. Al-Hawary,Stephen W. Behrman,Al B. Benson,Dana Backlund Cardin,E. Gabriela Chiorean,Vincent Chung,Brian G. Czito,Marco Del Chiaro,Mary Dillhoff,Timothy R. Donahue,Efrat Dotan,Cristina R. Ferrone,Christos Fountzilas,Jeffrey M. Hardacre,William G. Hawkins,Kelsey Klute,Andrew H. Ko,John W. Kunstman,Noelle K. LoConte,Andrew M. Lowy,Cassadie Moravek,Eric K. Nakakura,Amol Narang,Jorge Obando,Patricio M. Polanco,Sushanth Reddy,Marsha Reyngold,Courtney L. Scaife,Jeanne Shen,Charles M. Vollmer,Robert A. Wolff,Brian M. Wolpin,Beth Lynn,Giby V. George +35 more
Abstract: Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcinoma provides recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pancreatic cancer. Although survival rates remain relatively unchanged, newer modalities of treatment, including targeted therapies, provide hope for improving patient outcomes. Sections of the manuscript have been updated to be concordant with the most recent update to the guidelines. This manuscript focuses on the available systemic therapy approaches, specifically the treatment options for locally advanced and metastatic disease.
Journal ArticleDOI
Early Detection of Pancreatic Cancer: Opportunities and Challenges
TL;DR: Current and emerging imaging modalities that are critical to identifying early, potentially curable PDAC in high-risk cohorts on surveillance are discussed.
Journal ArticleDOI
Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression.
Vincent Bernard,Alexander Semaan,Jonathan Huang,F. Anthony San Lucas,Feven C Mulu,Bret M. Stephens,Paola A. Guerrero,Yanqing Huang,Jun Zhao,Nabiollah Kamyabi,Subrata Sen,Paul Scheet,Cullen M. Taniguchi,Michael P. Kim,Ching Wei D. Tzeng,Matthew Harold Katz,Aatur D. Singhi,Anirban Maitra,Hector A Alvarez +18 more
TL;DR: The ability to perform high-resolution profiling of the transcriptomic changes that occur during multistep progression of cystic PDAC precursors to cancer is demonstrated and might be a useful substrate to identify targets for cancer interception.
References
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Journal ArticleDOI
Typical and atypical manifestations of serous cystadenoma of the pancreas: imaging findings with pathologic correlation.
Jin-Young Choi,Myeong-Jin Kim,Jae Young Lee,Joon Seok Lim,Jae-Joon Chung,Ki Whang Kim,Hyung Sik Yoo +6 more
TL;DR: The purpose of this article is to present the typical and atypical manifestations of serous cystadenoma, which can be visualized with cross-sectional imaging.
Journal ArticleDOI
Targeted DNA Sequencing Reveals Patterns of Local Progression in the Pancreatic Remnant Following Resection of Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas.
Antonio Pea,Jun Yu,Neda Rezaee,Claudio Luchini,Jin He,Marco Dal Molin,James F. Griffin,Helen Fedor,Shahriar Fesharakizadeh,Roberto Salvia,Matthew J. Weiss,Claudio Bassi,John L. Cameron,Lei Zheng,Aldo Scarpa,Ralph H. Hruban,Anne Marie Lennon,Michael Goggins,Christopher L. Wolfgang,Laura D. Wood +19 more
TL;DR: Three mechanisms underlying local progression in the remnant pancreas are identified: residual microscopic disease at the resection margin, intraparenchymal spread of neoplastic cells, leading to an anatomically separate but genetically related recurrence, and multifocal disease with genetically distinct lesions.
Journal ArticleDOI
Evaluation of the Sendai and 2012 International Consensus Guidelines based on cross-sectional imaging findings performed for the initial triage of mucinous cystic lesions of the pancreas: a single institution experience with 114 surgically treated patients
Brian K. P. Goh,Brian K. P. Goh,Choon Hua Thng,Damien Tan,Albert S. C. Low,Jen-San Wong,Peng-Chung Cheow,Pierce K. H. Chow,Pierce K. H. Chow,Alexander Y. F. Chung,Wai-Keong Wong,London L.P.J. Ooi,London L.P.J. Ooi +12 more
TL;DR: Both the guidelines were useful in the initial cross-sectional imaging evaluation of mucinous CLPs and the ICG 2012 guidelines were superior to the SCG guidelines.
Journal ArticleDOI
The long term risk of malignancy in patients with branch duct intraductal papillary mucinous neoplasms of the pancreas.
Wafaa Khannoussi,Marie Pierre Vullierme,Vinciane Rebours,Frédérique Maire,Olivia Hentic,Alain Aubert,Alain Sauvanet,Safi Dokmak,Anne Couvelard,Pascal Hammel,Philippe Ruszniewski,Philippe Lévy +11 more
TL;DR: In patients with branch duct intraductal papillary mucinous neoplasms of the pancreas (BD-IPMN), the risk of malignant evolution persists after 60 months F/U including invasive carcinomas including invasive advanced carcinoma.
Journal ArticleDOI
Preoperative Predictors of Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasms
Chad A. Wiesenauer,C. Max Schmidt,Oscar W. Cummings,Constantin T. Yiannoutsos,Thomas J. Howard,Eric A. Wiebke,Eric A. Wiebke,Robert J. Goulet,Lee McHenry,Stuart Sherman,Glen A. Lehman,Harvey M. Cramer,James A. Madura +12 more
TL;DR: Malignancy of IPMNs is suggested by new-onset diabetes mellitus, jaundice, and elevations in serum glucose or alkaline phosphatase levels, which may help guide patient and physician decision making.
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