Journal ArticleDOI
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Masao Tanaka,Carlos Fernandez-del Castillo,Terumi Kamisawa,Jin-Young Jang,Philippe Lévy,Takao Ohtsuka,Roberto Salvia,Yasuhiro Shimizu,Minoru Tada,Christopher L. Wolfgang +9 more
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TLDR
The working group has revised the guidelines regarding prediction of invasive carcinoma and high-grade dysplasia, surveillance, and postoperative follow-up of IPMN and includes updated information and recommendations based on the current understanding.About:
This article is published in Pancreatology.The article was published on 2017-09-01. It has received 1104 citations till now.read more
Citations
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Journal ArticleDOI
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes
Andrew J McGuigan,Paul Kelly,Richard C. Turkington,C. Jones,Helen G. Coleman,R Stephen McCain +5 more
TL;DR: This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy.
Journal ArticleDOI
European evidence-based guidelines on pancreatic cystic neoplasms
Marco Del Chiaro,Marc G. Besselink,Lianne Scholten,Marco J. Bruno,Djuna L. Cahen,Thomas M. Gress,Jeanin E. van Hooft,Markus M. Lerch,Julia Mayerle,Thilo Hackert,Sohei Satoi,Alessandro Zerbi,David Cunningham,Claudio De Angelis,Marc Giovanni,Enrique de-Madaria,Péter Hegyi,Jonas Rosendahl,Helmut Friess,Riccardo Manfredi,Philippe Lévy,Francisco X. Real,Alain Sauvanet,Mohammed Abu Hilal,Giovanni Marchegiani,Irene Esposito,Paula Ghaneh,Marc R. W. Engelbrecht,Paul Fockens,Nadine C.M. van Huijgevoort,Christopher L. Wolfgang,Claudio Bassi,Natalya Gubergrits,Caroline S. Verbeke,Günter Klöppel,Aldo Scarpa,Giuseppe Zamboni,Anne Marie Lennon,Malin Sund,Nikolaos Kartalis,Lars Grenacher,Massimo Falconi,Urban Arnelo,Kostantin V. Kopchak,Kofi Oppong,Colin J. McKay,Truls Hauge,Kevin C. Conlon,Mustapha Adham,Güralp O. Ceyhan,Roberto Salvia,Christos Dervenis,Peter J. Allen,François Paye,Detlef K. Bartsch,Matthias Löhr,Massimiliano Mutignani,Johanna Laukkarinen,Richard D. Schulick,Roberto Valente,Thomas Seufferlein,Gabriele Capurso,Ajith K. Siriwardena,John P. Neoptolemos,Aldis Pukitis,Ralf Segersvärd,Ali A. Aghdassi,Stefano Andrianello,Peter Bossuyt,Robin Bülow,Karina Cárdenas-Jaén,P. Cortegoso,Martina Fontana,Lena Haeberle,M. Heckler,Andrey Litvin,Kulbir Mann,Christoph W. Michalski,Patrick Michl,Gennaro Nappo,Giampaolo Perri,S. Persson,F. Scheufele,Francesco Sclafani,Manuel Schmidt,L. Venezia,F. Volker,M-P Vullierm,L. Wusten +88 more
TL;DR: A conservative approach is recommended for asymptomatic MCN and IPMN, and Lifelong follow-up of IPMN is recommended in patients who are fit for surgery.
Journal ArticleDOI
Pancreatic adenocarcinoma, Version 2.2021
Margaret A. Tempero,Mokenge P. Malafa,Mahmoud M. Al-Hawary,Stephen W. Behrman,Al B. Benson,Dana Backlund Cardin,E. Gabriela Chiorean,Vincent Chung,Brian G. Czito,Marco Del Chiaro,Mary Dillhoff,Timothy R. Donahue,Efrat Dotan,Cristina R. Ferrone,Christos Fountzilas,Jeffrey M. Hardacre,William G. Hawkins,Kelsey Klute,Andrew H. Ko,John W. Kunstman,Noelle K. LoConte,Andrew M. Lowy,Cassadie Moravek,Eric K. Nakakura,Amol Narang,Jorge Obando,Patricio M. Polanco,Sushanth Reddy,Marsha Reyngold,Courtney L. Scaife,Jeanne Shen,Charles M. Vollmer,Robert A. Wolff,Brian M. Wolpin,Beth Lynn,Giby V. George +35 more
Abstract: Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcinoma provides recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pancreatic cancer. Although survival rates remain relatively unchanged, newer modalities of treatment, including targeted therapies, provide hope for improving patient outcomes. Sections of the manuscript have been updated to be concordant with the most recent update to the guidelines. This manuscript focuses on the available systemic therapy approaches, specifically the treatment options for locally advanced and metastatic disease.
Journal ArticleDOI
Early Detection of Pancreatic Cancer: Opportunities and Challenges
TL;DR: Current and emerging imaging modalities that are critical to identifying early, potentially curable PDAC in high-risk cohorts on surveillance are discussed.
Journal ArticleDOI
Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression.
Vincent Bernard,Alexander Semaan,Jonathan Huang,F. Anthony San Lucas,Feven C Mulu,Bret M. Stephens,Paola A. Guerrero,Yanqing Huang,Jun Zhao,Nabiollah Kamyabi,Subrata Sen,Paul Scheet,Cullen M. Taniguchi,Michael P. Kim,Ching Wei D. Tzeng,Matthew Harold Katz,Aatur D. Singhi,Anirban Maitra,Hector A Alvarez +18 more
TL;DR: The ability to perform high-resolution profiling of the transcriptomic changes that occur during multistep progression of cystic PDAC precursors to cancer is demonstrated and might be a useful substrate to identify targets for cancer interception.
References
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Journal ArticleDOI
Risk of Malignancy in Resected Cystic Tumors of the Pancreas ≤3 cm in Size: Is it Safe to Observe Asymptomatic Patients? A Multi-institutional Report
Cheong J. Lee,James M. Scheiman,Michelle A. Anderson,Oscar J. Hines,Howard A. Reber,J Farrell,Michael L. Kochman,Paul J. Foley,Jeffrey A. Drebin,Young S. Oh,Gregory G. Ginsberg,Nuzhat A. Ahmad,Nipun B. Merchant,James M. Isbell,Alexander A. Parikh,Jayme B. Stokes,Todd W. Bauer,Reid B. Adams,Diane M. Simeone +18 more
TL;DR: The purpose of this study was to determine the prevalence of malignancy in this group of patients using pancreatic resection databases from five high-volume pancreatic centers to assess the appropriateness of these guidelines.
Journal ArticleDOI
Cyst growth rate predicts malignancy in patients with branch duct intraductal papillary mucinous neoplasms.
Mee Joo Kang,Jin-Young Jang,Soo Jin Kim,Kyoung Bun Lee,Ji Kon Ryu,Yong-Tae Kim,Yong Bum Yoon,Sun Whe Kim +7 more
TL;DR: In combination with cyst size and the presence of mural nodules, cyst growth rate could be used to predict malignancy in patients with Br-IPMN.
Journal ArticleDOI
Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients
Chanjuan Shi,Alison P. Klein,Michael Goggins,Anirban Maitra,Marcia I. Canto,Syed Z. Ali,Richard D. Schulick,Emily Palmisano,Ralph H. Hruban +8 more
TL;DR: These findings can form a basis for the design of screening tests for the early detection of pancreatic neoplasia, and precursor lesions are of a higher grade in patients with a strong family history of pancreating cancer.
Journal ArticleDOI
Pancreatic cancer in patients with pancreatic cystic lesions: a prospective study in 197 patients.
Minoru Tada,Takao Kawabe,Masatoshi Arizumi,Osamu Togawa,Saburo Matsubara,Natsuyo Yamamoto,Y. Nakai,Naoki Sasahira,Kenji Hirano,Takeshi Tsujino,Keisuke Tateishi,Hiroyuki Isayama,Nobuo Toda,Haruhiko Yoshida,Masao Omata +14 more
TL;DR: Patients with pancreatic cystic lesions are at a considerably high risk for pancreatic cancer, with a standardized incidence rate of 22.5 times higher than expected mortality from this cancer among general population.
Journal ArticleDOI
Intraductal papillary mucinous neoplasms of the pancreas: differentiation of malignant and benign tumors by endoscopic ultrasound findings of mural nodules.
Eizaburo Ohno,Yoshiki Hirooka,Akihiro Itoh,Masatoshi Ishigami,Yoshiaki Katano,Naoki Ohmiya,Yasumasa Niwa,Hidemi Goto +7 more
TL;DR: New morphologic criteria were useful to identify the malignant potentials of IPMNs to identify predictors of malignancy using contrast-enhanced endoscopic ultrasound (CE-EUS).
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