Journal ArticleDOI
Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches.
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TLDR
A critical review of the development of specific chemotherapeutic approaches for the management of American Trypanosomiasis or Chagas disease is presented, and the most promising approaches are ergosterol biosynthesis inhibitors such as posaconazole and ravuconazole.About:
This article is published in Acta Tropica.The article was published on 2010-07-01. It has received 402 citations till now. The article focuses on the topics: Benznidazole & Nifurtimox.read more
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Journal ArticleDOI
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.
Israel Molina,Jordi Gómez i Prat,Fernando Salvador,Begoña Treviño,Elena Sulleiro,Nuria Serre,Diana Pou,Sílvia Roure,Juan Cabezos,Lluís Valerio,Albert Blanco-Grau,Adrián Sánchez-Montalvá,Xavier Vidal,Albert Pahissa +13 more
TL;DR: Posaconazole showed antitrypanosomal activity in patients with chronic Chagas' disease, however, significantly more patients in the posaconazoles groups than in the benznidazole group had treatment failure during follow-up.
Book ChapterDOI
Inhibition of Cytochrome P450 Enzymes
TL;DR: Cytochrome P450s (P450s) are subject to inhibition/inactivation by various chemically diverse agents, which may interact directly or indirectly with either the P450 prosthetic heme or the protein moiety or with both moieties.
Journal ArticleDOI
Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity.
TL;DR: The interplay between parasite and host genetics should have an important role in the definition of Chagas disease pathogenesis, anti-T.
Journal ArticleDOI
Antitrypanosomal Therapy for Chronic Chagas' Disease
TL;DR: A 42-year-old woman presents after donating blood and receiving a report that she is positive for Chagas' disease.
Journal ArticleDOI
The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases – Part I
Thomas J. Schmidt,Sami A. Khalid,Alvaro J. Romanha,T. Ma. Alves,Maique W. Biavatti,Reto Brun,FB Da Costa,S. L. De Castro,Vitor F. Ferreira,M. V. G. de Lacerda,João Henrique G. Lago,Leonor L. Leon,Norberto Peporine Lopes,R. C. das Neves Amorim,Michael Niehues,Ifedayo Victor Ogungbe,Adrian Martin Pohlit,Marcus Tullius Scotti,William N. Setzer,M. de N. C. Soeiro,M. Steindel,Andre G. Tempone +21 more
TL;DR: The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.
References
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Journal Article
Heart-lung transplantation.
TL;DR: A broad overview of the various grounds upon which this difference is likely based and discuss recent advances in each area: 1) criteria for the selection of candidates and donors, 2) methods for ex-vivo preservation of donor organs, 3) technical execution of the operative procedure, and 4) prevention of postoperative infection as discussed by the authors.
Journal ArticleDOI
Therapeutic approaches to bone diseases.
Gideon A. Rodan,T. John Martin +1 more
TL;DR: A better understanding of the biology of osteoclasts and osteoblasts is providing opportunities for developing therapeutics to treat diseases of bone, and promoting bone formation with growth factors or hormones is an approach that would be a valuable adjunct therapy for patients receiving inhibitors of bone resorption.
Journal ArticleDOI
The Genome of the African Trypanosome Trypanosoma brucei
Matthew Berriman,Elodie Ghedin,Elodie Ghedin,Christiane Hertz-Fowler,Gaëlle Blandin,Hubert Renauld,Daniella Castanheira Bartholomeu,Nicola Lennard,Elisabet Caler,N. Hamlin,Brian J. Haas,Ulrike Böhme,Linda Hannick,Martin Aslett,Joshua Shallom,Lucio Marcello,Lihua Hou,Bill Wickstead,U. Cecilia M. Alsmark,Claire Arrowsmith,Rebecca Atkin,Andrew Barron,Frédéric Bringaud,Karen Brooks,Mark Carrington,Inna Cherevach,Tracey-Jane Chillingworth,Carol Churcher,Louise Clark,Craig Corton,Ann Cronin,Robert L. Davies,Jonathon Doggett,Appolinaire Djikeng,Tamara Feldblyum,Mark C. Field,Audrey Fraser,Ian Goodhead,Zahra Hance,David Harper,Barbara Harris,Heidi Hauser,Jessica B. Hostetler,Al Ivens,Kay Jagels,David W. Johnson,Justin Johnson,Kristine Jones,Arnaud Kerhornou,Hean Koo,Natasha Larke,Scott M. Landfear,Christopher Larkin,Vanessa Leech,Alexandra Line,Angela Lord,Annette MacLeod,P. Mooney,Sharon Moule,David M. A. Martin,Gareth W. Morgan,Karen Mungall,Halina Norbertczak,Doug Ormond,Grace Pai,Christopher S. Peacock,Jeremy Peterson,Michael A. Quail,Ester Rabbinowitsch,Marie-Adèle Rajandream,Chris P Reitter,Steven L. Salzberg,Mandy Sanders,Seth Schobel,Sarah Sharp,Mark Simmonds,Anjana J. Simpson,Luke J. Tallon,C. Michael R. Turner,Andrew Tait,Adrian Tivey,Susan Van Aken,Danielle Walker,David Wanless,Shiliang Wang,Brian White,Owen White,Sally Whitehead,John Woodward,Jennifer R. Wortman,Mark Raymond Adams,T. Martin Embley,Keith Gull,Elisabetta Ullu,J. David Barry,Alan H. Fairlamb,Fred R. Opperdoes,Barclay G. Barrell,John E. Donelson,Neil Hall,Neil Hall,Claire M. Fraser,Sara E. Melville,Najib M. El-Sayed,Najib M. El-Sayed +104 more
TL;DR: Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences.
Journal ArticleDOI
The genome of the kinetoplastid parasite, Leishmania major.
Alasdair Ivens,Christopher S. Peacock,Elizabeth A. Worthey,Lee Murphy,Gautam Aggarwal,Matthew Berriman,Ellen Sisk,Marie-Adèle Rajandream,Ellen Adlem,Rita Aert,Atashi Anupama,Zina Apostolou,Philip Attipoe,Nathalie Bason,Christopher Bauser,Alfred Beck,Stephen M. Beverley,Gabriella Bianchettin,K. Borzym,G. Bothe,Carlo V. Bruschi,Carlo V. Bruschi,Matt Collins,Eithon Cadag,Laura Ciarloni,Christine Clayton,Richard M.R. Coulson,Ann Cronin,Angela K. Cruz,Robert L. Davies,Javier G. De Gaudenzi,Deborah E. Dobson,Andreas Duesterhoeft,Gholam Fazelina,Nigel Fosker,Alberto C.C. Frasch,Audrey Fraser,Monika Fuchs,Claudia Gabel,Arlette Goble,André Goffeau,David Harris,Christiane Hertz-Fowler,Helmut Hilbert,David Horn,Yiting Huang,Sven Klages,Andrew J Knights,Michael Kube,Natasha Larke,Lyudmila Litvin,Angela Lord,Tin Louie,Marco A. Marra,David Masuy,Keith R. Matthews,Shulamit Michaeli,Jeremy C. Mottram,Silke Müller-Auer,Heather Munden,Siri Nelson,Halina Norbertczak,Karen Oliver,Susan O'Neil,Martin Pentony,Thomas M. Pohl,Claire Price,Bénédicte Purnelle,Michael A. Quail,Ester Rabbinowitsch,Richard Reinhardt,Michael A. Rieger,Joel Rinta,Johan Robben,Laura Robertson,Jeronimo C. Ruiz,Simon Rutter,David L. Saunders,Melanie Schäfer,Jacquie Schein,David C. Schwartz,Kathy Seeger,Amber Seyler,Sarah Sharp,Heesun Shin,Dhileep Sivam,Rob Squares,Steve Squares,Valentina Tosato,Christy Vogt,Guido Volckaert,Rolf Wambutt,T. Warren,Holger Wedler,John Woodward,Shiguo Zhou,Wolfgang Zimmermann,Deborah F. Smith,Jenefer M. Blackwell,Kenneth Stuart,Kenneth Stuart,Bart Barrell,Peter J. Myler,Peter J. Myler +103 more
TL;DR: The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Tritryp genomes suggest that the mechanisms regulating RNA polymerase II–directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling.
Journal ArticleDOI
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
Najib M. El-Sayed,Peter J. Myler,Peter J. Myler,Daniella Castanheira Bartholomeu,Daniel Nilsson,Gautam Aggarwal,Anh-Nhi Tran,Elodie Ghedin,Elizabeth A. Worthey,Arthur L. Delcher,Gaëlle Blandin,Scott J. Westenberger,Elisabet Caler,Gustavo C. Cerqueira,Carole Branche,Brian J. Haas,Atashi Anupama,Erik Arner,Lena Åslund,Philip Attipoe,Esteban J. Bontempi,Frédéric Bringaud,Peter Burton,Eithon Cadag,David A. Campbell,Mark Carrington,Jonathan Crabtree,Hamid Darban,José Franco da Silveira,Pieter J. de Jong,Kimberly Edwards,Paul T. Englund,Gholam Fazelina,Tamara Feldblyum,Marcela Ferella,Alberto C.C. Frasch,Keith Gull,David Horn,Lihua Hou,Yiting Huang,Ellen Kindlund,Michele M. Klingbeil,Sindy Kluge,Hean Koo,Daniela R. Lacerda,Mariano J. Levin,Hernan Lorenzi,Tin Louie,Carlos Renato Machado,Richard McCulloch,Alan McKenna,Yumi Mizuno,Jeremy C. Mottram,Siri Nelson,Stephen Ochaya,Kazutoyo Osoegawa,Grace Pai,Marilyn Parsons,Marilyn Parsons,Martin Pentony,Ulf Pettersson,Mihai Pop,José Luis Ramírez,Joel Rinta,Laura Robertson,Steven L. Salzberg,Daniel O. Sánchez,Amber Seyler,Reuben Sunil Kumar Sharma,Jyoti Shetty,Anjana J. Simpson,Ellen Sisk,Martti T. Tammi,Martti T. Tammi,Rick L. Tarleton,Santuza M. R. Teixeira,Susan Van Aken,Christy Vogt,Pauline N. Ward,Bill Wickstead,Jennifer R. Wortman,Owen White,Claire M. Fraser,Kenneth Stuart,Kenneth Stuart,Björn Andersson +85 more
TL;DR: Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
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Specific chemotherapy of Chagas disease: controversies and advances.
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