Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis.
Liyan Mei,Zhihua Yang,Xiaolin Zhang,Zehao Liu,Maojie Wang,Maojie Wang,Xiaodong Wu,Xiu-Min Chen,Qingchun Huang,Run-Yue Huang +9 more
TLDR
Huang et al. as mentioned in this paper tracked the longitudinal changes in gut bacteria in 22 rheumatoid arthritis patients who were randomized into two groups and treated with Huayu-Qiangshen-Tongbi formula (HQT) plus methotrexate (MTX) or leflunomide (LEF) plus MTX.Abstract:
Several studies have investigated the causative role of the microbiome in the development of rheumatoid arthritis (RA), but changes in the gut microbiome in RA patients during drug treatment have been less well studied. Here, we tracked the longitudinal changes in gut bacteria in 22 RA patients who were randomized into two groups and treated with Huayu-Qiangshen-Tongbi formula (HQT) plus methotrexate (MTX) or leflunomide (LEF) plus MTX. There were differences in the gut microbiome between untreated (at baseline) RA patients and healthy controls, with 37 species being more abundant in the RA patients and 21 species (including Clostridium celatum) being less abundant. Regarding the functional analysis, vitamin K2 biosynthesis was associated with RA-enriched bacteria. Additionally, in RA patients, alterations in gut microbial species appeared to be associated with RA-related clinical indicators through changing various gut microbiome functional pathways. The clinical efficacy of the two treatments was further observed to be similar, but the response trends of RA-related clinical indices in the two treatment groups differed. For example, HQT treatment affected the erythrocyte sedimentation rate (ESR), while LEF treatment affected the C-reactive protein (CRP) level. Further, 11 species and 9 metabolic pathways significantly changed over time in the HQT group (including C. celatum, which increased), while only 4 species and 2 metabolic pathways significantly changed over time in the LEF group. In summary, we studied the alterations in the gut microbiome of RA patients being treated with HQT or LEF. The results provide useful information on the role of the gut microbiota in the pathogenesis of RA, and they also provide potentially effective directions for developing new RA treatments.read more
Citations
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Journal ArticleDOI
Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities
TL;DR: The impact of gut dysbiosis in the pathogenesis of RA, the selection of gut microbiota-related biomarkers for diagnosing RA, and examples of cross-modulation between the gut microbiota and some drugs commonly used to treat RA are discussed.
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Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases
TL;DR: This review aims to summarize the current knowledge about gut microbiota dysbiosis and the potential of FMT in studying the pathogeneses and therapies of autoimmune diseases and discusses the extraintestinal autoimmune pathologies with at least one published or ongoing FMT study in human or animal models.
Journal ArticleDOI
Intestinal microbiome–rheumatoid arthritis crosstalk: The therapeutic role of probiotics
Yeboah Kwaku Opoku,Kwame Kumi Asare,George Ghartey-Quansah,Justice Afrifa,Felicity Bentsi-Enchill,Eric Gyamerah Ofori,Charles Kwesi Koomson,Rosemary Naana Kumi-Manu +7 more
TL;DR: Although strain-specific, probiotic supplementation as adjuvant therapy for the management of RA is very promising and warrants more research.
Journal ArticleDOI
Deleterious Effect of Air Pollution on Human Microbial Community and Bacterial Flora: A Short Review
Nishant Gupta,Virendra Kumar Yadav,A. Gacem,Mona Al-Dossari,Krishna Kumar Yadav,N. S. Abd El-Gawaad,N. Ben Khedher,Nisha Choudhary,Pankaj Kumar,Simona Cavalu +9 more
TL;DR: In this paper , the authors have summarized and discussed recent studies' outcomes related to air pollution-driven microbiotas' dysbiosis (including oral, nasal, respiratory, gut, skin, and thyroid) and its potential multi-organ health risks.
Journal ArticleDOI
Effects of Metabolic Disorders in Immune Cells and Synoviocytes on the Development of Rheumatoid Arthritis
Alexander V. Blagov,Andrey V. Grechko,Nikita G. Nikiforov,A.D. Zhuravlev,Nikolay K. Sadykhov,Alexander N. Orekhov +5 more
TL;DR: The connection between metabolism and inflammation in the context of rheumatoid arthritis is described and in detail the changes in metabolic processes and their subsequent immunomodulatory effects are considered.
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TL;DR: It is suggested that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma and high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment.
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