Journal ArticleDOI
The oral and gut microbiome in rheumatoid arthritis patients: a systematic review
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In this paper, the authors conducted a comprehensive review of the pertinent literature to describe the possible association between RA and the microbiome of the oral cavity and gut, and identified the microbiome associated with RA patients in comparison with controls.Abstract:
Background Recently, researchers have proposed a possible relationship between RA and the microbiome of the oral cavity and gut. However, this relation has not been systematically established. Herein, we conducted a comprehensive review of the pertinent literature to describe this possible association. Methods We systematically performed searches in databases, namely EMBASE, the Cochrane Library, and PubMed, from inception to 7 June 2020 to identify case-control studies that compared the oral and gut microbiome in adult RA patients with those of controls. The primary outcome was specific bacterial changes between RA and controls. The secondary outcome was microbial diversity changes between RA and controls. Results In total, 26 articles were considered eligible for inclusion and reported some differences. Therein, ≥3 articles reported decreased Faecalibacterium in the gut of early-RA (ERA)/RA patients compared with healthy controls (HCs). Also, ≥3 articles reported decreased Streptococcus and Haemophilus and increased Prevotella in the oral cavity of ERA/RA patients compared with HCs. In addition, some Prevotella species, including P. histicola and P. oulorum, showed increased trends in RA patients' oral cavity, compared with HCs. The α-diversity of the microbiome was either increased or not changed in the oral cavity of RA patients, but it was more commonly either decreased or not changed in the gut of RA patients. Conclusions In this systematic review, we identified the microbiome associated with RA patients in comparison with controls. More research is needed in the future to find the deep relationship between RA and the microbiome.read more
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Journal ArticleDOI
Targeting Probiotics in Rheumatoid Arthritis.
Simona Bungau,Tapan Behl,Anuja Singh,Aayush Sehgal,Sukhbir Singh,Sridevi Chigurupati,Shantini Vijayabalan,Suprava Das,Vasanth Raj Palanimuthu +8 more
TL;DR: A recent review as discussed by the authors highlights the known data on the therapeutic and preventative effects of probiotic microorganisms in RA, as well as their interactions, and concludes that probiotic administration has anti-inflammatory benefits, helps people with RA enhance daily activities and alleviates symptoms.
Journal ArticleDOI
The Gut Microbiome and Metabolites Are Altered and Interrelated in Patients With Rheumatoid Arthritis
Die Yu,Juping Du,Xia Pu,Liyuan Zheng,Shuaishuai Chen,Na Wang,Jun Li,Shiyong Chen,Shaobiao Pan,Bo Shen +9 more
TL;DR: The overall landscape of the intestinal microbiome and metabolome in RA patients was depicted to provide possible novel research directions regarding RA pathogenesis and targeted therapy and revealed that the gut microbiome and metabolites were interrelated in the RA patients, while Escherichia was the core genus.
Journal ArticleDOI
Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies
Yilun Wang,Jie Wei,Wei Zhang,Michael Doherty,Yuqing Zhang,Haibin Xie,Wei Li,Ning Wang,Guanghua Lei,Chao Zeng +9 more
TL;DR: In this article , Wu et al. synthesize the accumulating evidence for the relation of gut microbiota to rheumatic diseases by searching the PubMed, Embase and Cochrane Library from inception to March 11, 2022 to include observational studies evaluating the associations between gut microbiota and rheumatoid diseases.
Journal ArticleDOI
Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of Lactobacillus casei and Lactobacillus acidophilus
Alok Kumar Paul,Anita Paul,Rownak Jahan,Khoshnur Jannat,Tohmina Afroze Bondhon,Anamul Hasan,Veeranoot Nissapatorn,Maria de Lourdes Pereira,Polrat Wilairatana,Mohammed Rahmatullah +9 more
TL;DR: In this paper, the authors summarize the findings of recent studies to understand the overall pathogenesis of rheumatoid arthritis and the roles of probiotics, particularly Lactobacillus casei or L. acidophilus, in clinical and preclinical studies.
Journal ArticleDOI
The Role of Medicinal and Aromatic Plants against Obesity and Arthritis: A Review
Alok Kumar Paul,Rownak Jahan,Anita Paul,Tooba Mahboob,Tohmina Afroze Bondhon,Khoshnur Jannat,Anamul Hasan,Veeranoot Nissapatorn,Polrat Wilairatana,Maria de Lourdes Pereira,Christophe Wiart,Mohammed Rahmatullah +11 more
TL;DR: This review is an attempt to understand the pathophysiological connections between obesity and arthritis, and describes treatment options derived from medicinal, spice, and aromatic plants.
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TL;DR: The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Journal ArticleDOI
Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
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The pathogenesis of rheumatoid arthritis.
Iain B. McInnes,Georg Schett +1 more
TL;DR: The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.
Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Jose U. Scher,Andrew Sczesnak,Andrew Sczesnak,Randy S. Longman,Randy S. Longman,Nicola Segata,Nicola Segata,Carles Ubeda,Carles Ubeda,Craig M. Bielski,Tim Rostron,Vincenzo Cerundolo,Eric G. Pamer,Steven B. Abramson,Curtis Huttenhower,Dan R. Littman +15 more
TL;DR: The presence of Prevotella copri is identified as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients and uniquePrevotella genes that correlate with disease are identified.