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The journal of neuroscience : the official journal of the Society for Neuroscience.
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The article was published on 1981-01-01 and is currently open access. It has received 1737 citations till now.read more
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Journal ArticleDOI
Cortisol-dehydroepiandrosterone ratios are inversely associated with hippocampal and prefrontal brain volume in schizophrenia
Ellen Ji,Cynthia Shannon Weickert,Tertia D. Purves-Tyson,Christopher J. White,David J. Handelsman,Reena Desai,Maryanne O'Donnell,Dennis Liu,Cherrie Galletly,Rhoshel K. Lenroot,Thomas W. Weickert +10 more
TL;DR: The results further implicate the role of DHEA and hypothalamic-pituitary-adrenal axis dysfunction in the pathophysiology of schizophrenia, and suggest that the cortisol/DHEA ratio may be a molecular blood signature of hippocampal and cortical damage.
Posted ContentDOI
3′ UTR Remodelling of Axonal Transcripts in Sympathetic Neurons
Catia Andreassi,Raphaëlle Luisier,Hamish Crerar,Sasja Franke,Nicholas M. Luscombe,Giovanni Cuda,Marco Gaspari,Antonella Riccio +7 more
TL;DR: It is concluded that the 3’ UTR of neuronal transcripts undergo post-transcriptional remodelling and an alternative mechanism that regulates local protein synthesis is described that regulatesLocal protein synthesis.
Journal ArticleDOI
Neuronal network remodeling and Wnt pathway dysregulation in the intra-hippocampal kainate mouse model of temporal lobe epilepsy
Kunal Gupta,Eric Schnell +1 more
TL;DR: The results demonstrate regional variation in Wnt pathway dysregulation early after seizure induction, and suggest that some Wnt-mediated effects might actually temper aberrant neurogenesis after seizures, and provide suitable targets for novel therapies that prevent network remodeling and the development of epileptic foci in high-risk patients.
Antagonistic negative and positive neurons of the basolateral amygdala
TL;DR: The authors identified two genetic markers defining non-overlapping populations of principal cells in the amygdala that respond to stimuli of opposite valence, which contribute to behavioral responses to aversive or rewarding experiences, are distributed along antero-posterior gradients that run in opposite directions.
Journal ArticleDOI
Image identification from brain activity using the population receptive field model.
TL;DR: The biologically inspired population receptive field (pRF) approach is used to identify presented images from fMRI recordings of the visual cortex, using an explicit model of the underlying neural response selectivity to identify visual images using the most fundamental low-parameter pRF model estimated from conventional pRF mapping stimuli.
References
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Journal ArticleDOI
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
F. Kyle Satterstrom,F. Kyle Satterstrom,Jack A. Kosmicki,Jiebiao Wang,Michael S. Breen,Silvia De Rubeis,Joon Yong An,Joon Yong An,Minshi Peng,Ryan Collins,Jakob Grove,Jakob Grove,Lambertus Klei,Christine Stevens,Jennifer Reichert,Maureen Mulhern,Mykyta Artomov,Sherif Gerges,Brooke Sheppard,Xinyi Xu,Aparna Bhaduri,Utku Norman,Harrison Brand,Grace Schwartz,Rachel Nguyen,Elizabeth E. Guerrero,Caroline Dias,Branko Aleksic,Richard Anney,Mafalda Barbosa,Somer L. Bishop,Alfredo Brusco,Jonas Bybjerg-Grauholm,Angel Carracedo,Marcus C.Y. Chan,Andreas G. Chiocchetti,Brian H.Y. Chung,Hilary Coon,Michael L. Cuccaro,Aurora Currò,Bernardo Dalla Bernardina,Ryan N. Doan,Enrico Domenici,Shan Dong,Chiara Fallerini,Montserrat Fernández-Prieto,Giovanni Battista Ferrero,Christine M. Freitag,Menachem Fromer,J. Jay Gargus,Daniel H. Geschwind,Elisa Giorgio,Javier González-Peñas,Stephen J. Guter,Danielle Halpern,Emily Hansen-Kiss,Xin He,Gail E. Herman,Irva Hertz-Picciotto,David M. Hougaard,Christina M. Hultman,Iuliana Ionita-Laza,Suma Jacob,Jesslyn Jamison,Astanand Jugessur,Miia Kaartinen,Gun Peggy Knudsen,Alexander Kolevzon,Itaru Kushima,So Lun Lee,Terho Lehtimäki,Elaine T. Lim,Carla Lintas,W. Ian Lipkin,Diego Lopergolo,Fátima Lopes,Yunin Ludena,Patrícia Maciel,Per Magnus,Behrang Mahjani,Nell Maltman,Dara S. Manoach,Gal Meiri,Idan Menashe,Judith Miller,Nancy J. Minshew,Eduarda Montenegro M. de Souza,Danielle de Paula Moreira,Eric M. Morrow,Ole Mors,Preben Bo Mortensen,Matthew W. Mosconi,Pierandrea Muglia,Benjamin M. Neale,Merete Nordentoft,Norio Ozaki,Aarno Palotie,Mara Parellada,Maria Rita Passos-Bueno,Margaret A. Pericak-Vance,Antonio M. Persico,Isaac N. Pessah,Kaija Puura,Abraham Reichenberg,Alessandra Renieri,Evelise Riberi,Elise B. Robinson,Elise B. Robinson,Kaitlin E. Samocha,Sven Sandin,Sven Sandin,Susan L. Santangelo,Susan L. Santangelo,Gerry Schellenberg,Stephen W. Scherer,Sabine Schlitt,Rebecca J. Schmidt,Lauren M. Schmitt,Isabela Maya Wahys Silva,Tarjinder Singh,Tarjinder Singh,Paige M. Siper,Moyra Smith,Gabriela Soares,Camilla Stoltenberg,Pål Surén,Ezra Susser,John A. Sweeney,Peter Szatmari,Lara Tang,Flora Tassone,Karoline Teufel,Elisabetta Trabetti,Maria del Pilar Trelles,Christopher A. Walsh,Lauren A. Weiss,Thomas Werge,Donna M. Werling,Emilie M. Wigdor,Emilie M. Wigdor,Emma Wilkinson,A. Jeremy Willsey,Timothy W. Yu,Mullin H.C. Yu,Ryan Yuen,Elaine Cristina Zachi,Esben Agerbo,Thomas Damm Als,Vivek Appadurai,Marie Bækvad-Hansen,Rich Belliveau,Alfonso Buil,Caitlin E. Carey,Felecia Cerrato,Kimberly Chambert,Claire Churchhouse,Claire Churchhouse,Søren Dalsgaard,Ditte Demontis,Ashley Dumont,Jacqueline I. Goldstein,Christine Søholm Hansen,Mads E. Hauberg,Mads E. Hauberg,Mads E. Hauberg,Mads V. Hollegaard,Daniel P. Howrigan,Hailiang Huang,Julian Maller,Alicia R. Martin,Joanna Martin,Manuel Mattheisen,Jennifer L. Moran,Jonatan Pallesen,Duncan S. Palmer,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Timothy Poterba,Jesper Buchhave Poulsen,Stephan Ripke,Andrew J. Schork,Wesley K. Thompson,Patrick Turley,Raymond K. Walters,Catalina Betancur,Edwin H. Cook,Louise Gallagher,Michael Gill,James S. Sutcliffe,Audrey Thurm,Michael E. Zwick,Anders D. Børglum,Matthew W. State,A. Ercument Cicek,A. Ercument Cicek,Michael E. Talkowski,David J. Cutler,Bernie Devlin,Stephen Sanders,Kathryn Roeder,Mark J. Daly,Joseph D. Buxbaum +201 more
TL;DR: The largest exome sequencing study of autism spectrum disorder (ASD) to date, using an enhanced analytical framework to integrate de novo and case-control rare variation, identifies 102 risk genes at a false discovery rate of 0.1 or less, consistent with multiple paths to an excitatory-inhibitory imbalance underlying ASD.
Independent optical excitation of distinct neural populations
Nathan C. Klapoetke,Yasunobu Murata,Sung Soo Kim,Stefan R. Pulver,Amanda Birdsey-Benson,Yong Ku Cho,Tania K. Morimoto,Amy S. Chuong,Eric J. Carpenter,Zhijian Tian,Jun Wang,Yinlong Xie,Zhixiang Yan,Yong Zhang,Brian Y. Chow,Barbara Surek,Michael Melkonian,Vivek Jayaraman,Martha Constantine-Paton,Gane Ka-Shu Wong,Edward S. Boyden +20 more
TL;DR: Chronos and Chrimson as mentioned in this paper have been shown to enable two-color activation of neural spiking and downstream synaptic transmission in independent neural populations without detectable cross-talk in mouse brain slice.
Journal ArticleDOI
Visual Areas Exert Feedforward and Feedback Influences through Distinct Frequency Channels
André M. Bastos,André M. Bastos,André M. Bastos,Julien Vezoli,Conrado A. Bosman,Conrado A. Bosman,Jan-Mathijs Schoffelen,Robert Oostenveld,Jarrod R Dowdall,Peter De Weerd,Peter De Weerd,Henry Kennedy,Henry Kennedy,Pascal Fries,Pascal Fries +14 more
TL;DR: It is demonstrated that feedforward and feedback signaling use distinct frequency channels, suggesting that they subserve differential communication requirements.
Journal ArticleDOI
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
Agnes Roczniak-Ferguson,Constance S. Petit,Florian Froehlich,Sharon Qian,Jennifer Ky,Brittany Angarola,Tobias C. Walther,Shawn M. Ferguson +7 more
TL;DR: TFEB is identified as a target of mTOR and a mechanism for matching the transcriptional regulation of genes encoding proteins of autophagosomes and lysosomes to cellular need is suggested.
Journal ArticleDOI
Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo
Jonathan Viventi,Dae-Hyeong Kim,Leif Vigeland,Eric S. Frechette,Justin A. Blanco,Yun-Soung Kim,Andrew E. Avrin,Vineet Tiruvadi,Suk Won Hwang,Ann C. Vanleer,Drausin Wulsin,Kathryn A. Davis,Casey E. Gelber,Larry A. Palmer,Jan Van der Spiegel,Jian Wu,Jianliang Xiao,Yonggang Huang,Diego Contreras,John A. Rogers,Brian Litt +20 more
TL;DR: This system is used to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures, and it is found that seizures may manifest as recurrent spiral waves that propagate in the neocortex.