Open Access
The journal of neuroscience : the official journal of the Society for Neuroscience.
Reads0
Chats0
About:
The article was published on 1981-01-01 and is currently open access. It has received 1737 citations till now.read more
Citations
More filters
Journal ArticleDOI
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
F. Kyle Satterstrom,F. Kyle Satterstrom,Jack A. Kosmicki,Jiebiao Wang,Michael S. Breen,Silvia De Rubeis,Joon Yong An,Joon Yong An,Minshi Peng,Ryan Collins,Jakob Grove,Jakob Grove,Lambertus Klei,Christine Stevens,Jennifer Reichert,Maureen Mulhern,Mykyta Artomov,Sherif Gerges,Brooke Sheppard,Xinyi Xu,Aparna Bhaduri,Utku Norman,Harrison Brand,Grace Schwartz,Rachel Nguyen,Elizabeth E. Guerrero,Caroline Dias,Branko Aleksic,Richard Anney,Mafalda Barbosa,Somer L. Bishop,Alfredo Brusco,Jonas Bybjerg-Grauholm,Angel Carracedo,Marcus C.Y. Chan,Andreas G. Chiocchetti,Brian H.Y. Chung,Hilary Coon,Michael L. Cuccaro,Aurora Currò,Bernardo Dalla Bernardina,Ryan N. Doan,Enrico Domenici,Shan Dong,Chiara Fallerini,Montserrat Fernández-Prieto,Giovanni Battista Ferrero,Christine M. Freitag,Menachem Fromer,J. Jay Gargus,Daniel H. Geschwind,Elisa Giorgio,Javier González-Peñas,Stephen J. Guter,Danielle Halpern,Emily Hansen-Kiss,Xin He,Gail E. Herman,Irva Hertz-Picciotto,David M. Hougaard,Christina M. Hultman,Iuliana Ionita-Laza,Suma Jacob,Jesslyn Jamison,Astanand Jugessur,Miia Kaartinen,Gun Peggy Knudsen,Alexander Kolevzon,Itaru Kushima,So Lun Lee,Terho Lehtimäki,Elaine T. Lim,Carla Lintas,W. Ian Lipkin,Diego Lopergolo,Fátima Lopes,Yunin Ludena,Patrícia Maciel,Per Magnus,Behrang Mahjani,Nell Maltman,Dara S. Manoach,Gal Meiri,Idan Menashe,Judith Miller,Nancy J. Minshew,Eduarda Montenegro M. de Souza,Danielle de Paula Moreira,Eric M. Morrow,Ole Mors,Preben Bo Mortensen,Matthew W. Mosconi,Pierandrea Muglia,Benjamin M. Neale,Merete Nordentoft,Norio Ozaki,Aarno Palotie,Mara Parellada,Maria Rita Passos-Bueno,Margaret A. Pericak-Vance,Antonio M. Persico,Isaac N. Pessah,Kaija Puura,Abraham Reichenberg,Alessandra Renieri,Evelise Riberi,Elise B. Robinson,Elise B. Robinson,Kaitlin E. Samocha,Sven Sandin,Sven Sandin,Susan L. Santangelo,Susan L. Santangelo,Gerry Schellenberg,Stephen W. Scherer,Sabine Schlitt,Rebecca J. Schmidt,Lauren M. Schmitt,Isabela Maya Wahys Silva,Tarjinder Singh,Tarjinder Singh,Paige M. Siper,Moyra Smith,Gabriela Soares,Camilla Stoltenberg,Pål Surén,Ezra Susser,John A. Sweeney,Peter Szatmari,Lara Tang,Flora Tassone,Karoline Teufel,Elisabetta Trabetti,Maria del Pilar Trelles,Christopher A. Walsh,Lauren A. Weiss,Thomas Werge,Donna M. Werling,Emilie M. Wigdor,Emilie M. Wigdor,Emma Wilkinson,A. Jeremy Willsey,Timothy W. Yu,Mullin H.C. Yu,Ryan Yuen,Elaine Cristina Zachi,Esben Agerbo,Thomas Damm Als,Vivek Appadurai,Marie Bækvad-Hansen,Rich Belliveau,Alfonso Buil,Caitlin E. Carey,Felecia Cerrato,Kimberly Chambert,Claire Churchhouse,Claire Churchhouse,Søren Dalsgaard,Ditte Demontis,Ashley Dumont,Jacqueline I. Goldstein,Christine Søholm Hansen,Mads E. Hauberg,Mads E. Hauberg,Mads E. Hauberg,Mads V. Hollegaard,Daniel P. Howrigan,Hailiang Huang,Julian Maller,Alicia R. Martin,Joanna Martin,Manuel Mattheisen,Jennifer L. Moran,Jonatan Pallesen,Duncan S. Palmer,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Timothy Poterba,Jesper Buchhave Poulsen,Stephan Ripke,Andrew J. Schork,Wesley K. Thompson,Patrick Turley,Raymond K. Walters,Catalina Betancur,Edwin H. Cook,Louise Gallagher,Michael Gill,James S. Sutcliffe,Audrey Thurm,Michael E. Zwick,Anders D. Børglum,Matthew W. State,A. Ercument Cicek,A. Ercument Cicek,Michael E. Talkowski,David J. Cutler,Bernie Devlin,Stephen Sanders,Kathryn Roeder,Mark J. Daly,Joseph D. Buxbaum +201 more
TL;DR: The largest exome sequencing study of autism spectrum disorder (ASD) to date, using an enhanced analytical framework to integrate de novo and case-control rare variation, identifies 102 risk genes at a false discovery rate of 0.1 or less, consistent with multiple paths to an excitatory-inhibitory imbalance underlying ASD.
Independent optical excitation of distinct neural populations
Nathan C. Klapoetke,Yasunobu Murata,Sung Soo Kim,Stefan R. Pulver,Amanda Birdsey-Benson,Yong Ku Cho,Tania K. Morimoto,Amy S. Chuong,Eric J. Carpenter,Zhijian Tian,Jun Wang,Yinlong Xie,Zhixiang Yan,Yong Zhang,Brian Y. Chow,Barbara Surek,Michael Melkonian,Vivek Jayaraman,Martha Constantine-Paton,Gane Ka-Shu Wong,Edward S. Boyden +20 more
TL;DR: Chronos and Chrimson as mentioned in this paper have been shown to enable two-color activation of neural spiking and downstream synaptic transmission in independent neural populations without detectable cross-talk in mouse brain slice.
Journal ArticleDOI
Visual Areas Exert Feedforward and Feedback Influences through Distinct Frequency Channels
André M. Bastos,André M. Bastos,André M. Bastos,Julien Vezoli,Conrado A. Bosman,Conrado A. Bosman,Jan-Mathijs Schoffelen,Robert Oostenveld,Jarrod R Dowdall,Peter De Weerd,Peter De Weerd,Henry Kennedy,Henry Kennedy,Pascal Fries,Pascal Fries +14 more
TL;DR: It is demonstrated that feedforward and feedback signaling use distinct frequency channels, suggesting that they subserve differential communication requirements.
Journal ArticleDOI
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
Agnes Roczniak-Ferguson,Constance S. Petit,Florian Froehlich,Sharon Qian,Jennifer Ky,Brittany Angarola,Tobias C. Walther,Shawn M. Ferguson +7 more
TL;DR: TFEB is identified as a target of mTOR and a mechanism for matching the transcriptional regulation of genes encoding proteins of autophagosomes and lysosomes to cellular need is suggested.
Journal ArticleDOI
Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo
Jonathan Viventi,Dae-Hyeong Kim,Leif Vigeland,Eric S. Frechette,Justin A. Blanco,Yun-Soung Kim,Andrew E. Avrin,Vineet Tiruvadi,Suk Won Hwang,Ann C. Vanleer,Drausin Wulsin,Kathryn A. Davis,Casey E. Gelber,Larry A. Palmer,Jan Van der Spiegel,Jian Wu,Jianliang Xiao,Yonggang Huang,Diego Contreras,John A. Rogers,Brian Litt +20 more
TL;DR: This system is used to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures, and it is found that seizures may manifest as recurrent spiral waves that propagate in the neocortex.
References
More filters
Journal ArticleDOI
Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy.
Julius O. Enoru,Barbara Yang,Sesha Krishnamachari,Ernesto Villanueva,William DeMaio,Adiba Watanyar,Ramesh Chinnasamy,Jeffrey B. Arterburn,Ruth G. Perez +8 more
TL;DR: FTY720-C2 and FTY 720-Mitoxy both crossed the blood-brain-barrier; produced metabolites similar to FTY720, except without phosphorylated species that cause S1P1-mediated-immunosuppression; and were stimulated in vivo PP2A activity, all of which encourage additional preclinical assessment.
Journal ArticleDOI
Hypermetabolic Cerebellar Connectome in Alzheimer's Disease.
TL;DR: It is suggested that hypermetabolism in the cerebellum associated with AD may play an important role in forming the AD-related metabolic network.
Journal ArticleDOI
Central Nervous Activity upon Systemic Salicylate Application in Animals with Kanamycin-Induced Hearing Loss - A Manganese-Enhanced MRI (MEMRI) Study
TL;DR: In this article, the effect of systemic salicylate on central auditory and non-auditory structures in mice was investigated using the non-invasive manganeseenhanced magnetic resonance imaging technique.
Journal ArticleDOI
New Phosphospecific Antibody Reveals Isoform-Specific Phosphorylation of CPEB3 Protein.
Lech Kaczmarczyk,Étienne Labrie-Dion,Kapil Sehgal,Marc Sylvester,Magdalena Skubal,Michele Josten,Christian Steinhäuser,Paul De Koninck,Martin Theis +8 more
TL;DR: It is determined that putative neuronal isoforms of CPEB3 are phosphorylated, and the existence of a splicing-based regulatory mechanism of C PEB function is suggested, and a robust phosphospecific antibody is described to study it in future.
Journal ArticleDOI
Electrophysiological and hemodynamic mismatch responses in rats listening to human speech syllables.
TL;DR: It is suggested that rats more effectively processed the speech envelope than fine temporal cues in contrast with human preterm neonates, in whom the opposite effects were observed.