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The journal of neuroscience : the official journal of the Society for Neuroscience.
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The article was published on 1981-01-01 and is currently open access. It has received 1737 citations till now.read more
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Journal ArticleDOI
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
F. Kyle Satterstrom,F. Kyle Satterstrom,Jack A. Kosmicki,Jiebiao Wang,Michael S. Breen,Silvia De Rubeis,Joon Yong An,Joon Yong An,Minshi Peng,Ryan Collins,Jakob Grove,Jakob Grove,Lambertus Klei,Christine Stevens,Jennifer Reichert,Maureen Mulhern,Mykyta Artomov,Sherif Gerges,Brooke Sheppard,Xinyi Xu,Aparna Bhaduri,Utku Norman,Harrison Brand,Grace Schwartz,Rachel Nguyen,Elizabeth E. Guerrero,Caroline Dias,Branko Aleksic,Richard Anney,Mafalda Barbosa,Somer L. Bishop,Alfredo Brusco,Jonas Bybjerg-Grauholm,Angel Carracedo,Marcus C.Y. Chan,Andreas G. Chiocchetti,Brian H.Y. Chung,Hilary Coon,Michael L. Cuccaro,Aurora Currò,Bernardo Dalla Bernardina,Ryan N. Doan,Enrico Domenici,Shan Dong,Chiara Fallerini,Montserrat Fernández-Prieto,Giovanni Battista Ferrero,Christine M. Freitag,Menachem Fromer,J. Jay Gargus,Daniel H. Geschwind,Elisa Giorgio,Javier González-Peñas,Stephen J. Guter,Danielle Halpern,Emily Hansen-Kiss,Xin He,Gail E. Herman,Irva Hertz-Picciotto,David M. Hougaard,Christina M. Hultman,Iuliana Ionita-Laza,Suma Jacob,Jesslyn Jamison,Astanand Jugessur,Miia Kaartinen,Gun Peggy Knudsen,Alexander Kolevzon,Itaru Kushima,So Lun Lee,Terho Lehtimäki,Elaine T. Lim,Carla Lintas,W. Ian Lipkin,Diego Lopergolo,Fátima Lopes,Yunin Ludena,Patrícia Maciel,Per Magnus,Behrang Mahjani,Nell Maltman,Dara S. Manoach,Gal Meiri,Idan Menashe,Judith Miller,Nancy J. Minshew,Eduarda Montenegro M. de Souza,Danielle de Paula Moreira,Eric M. Morrow,Ole Mors,Preben Bo Mortensen,Matthew W. Mosconi,Pierandrea Muglia,Benjamin M. Neale,Merete Nordentoft,Norio Ozaki,Aarno Palotie,Mara Parellada,Maria Rita Passos-Bueno,Margaret A. Pericak-Vance,Antonio M. Persico,Isaac N. Pessah,Kaija Puura,Abraham Reichenberg,Alessandra Renieri,Evelise Riberi,Elise B. Robinson,Elise B. Robinson,Kaitlin E. Samocha,Sven Sandin,Sven Sandin,Susan L. Santangelo,Susan L. Santangelo,Gerry Schellenberg,Stephen W. Scherer,Sabine Schlitt,Rebecca J. Schmidt,Lauren M. Schmitt,Isabela Maya Wahys Silva,Tarjinder Singh,Tarjinder Singh,Paige M. Siper,Moyra Smith,Gabriela Soares,Camilla Stoltenberg,Pål Surén,Ezra Susser,John A. Sweeney,Peter Szatmari,Lara Tang,Flora Tassone,Karoline Teufel,Elisabetta Trabetti,Maria del Pilar Trelles,Christopher A. Walsh,Lauren A. Weiss,Thomas Werge,Donna M. Werling,Emilie M. Wigdor,Emilie M. Wigdor,Emma Wilkinson,A. Jeremy Willsey,Timothy W. Yu,Mullin H.C. Yu,Ryan Yuen,Elaine Cristina Zachi,Esben Agerbo,Thomas Damm Als,Vivek Appadurai,Marie Bækvad-Hansen,Rich Belliveau,Alfonso Buil,Caitlin E. Carey,Felecia Cerrato,Kimberly Chambert,Claire Churchhouse,Claire Churchhouse,Søren Dalsgaard,Ditte Demontis,Ashley Dumont,Jacqueline I. Goldstein,Christine Søholm Hansen,Mads E. Hauberg,Mads E. Hauberg,Mads E. Hauberg,Mads V. Hollegaard,Daniel P. Howrigan,Hailiang Huang,Julian Maller,Alicia R. Martin,Joanna Martin,Manuel Mattheisen,Jennifer L. Moran,Jonatan Pallesen,Duncan S. Palmer,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Timothy Poterba,Jesper Buchhave Poulsen,Stephan Ripke,Andrew J. Schork,Wesley K. Thompson,Patrick Turley,Raymond K. Walters,Catalina Betancur,Edwin H. Cook,Louise Gallagher,Michael Gill,James S. Sutcliffe,Audrey Thurm,Michael E. Zwick,Anders D. Børglum,Matthew W. State,A. Ercument Cicek,A. Ercument Cicek,Michael E. Talkowski,David J. Cutler,Bernie Devlin,Stephen Sanders,Kathryn Roeder,Mark J. Daly,Joseph D. Buxbaum +201 more
TL;DR: The largest exome sequencing study of autism spectrum disorder (ASD) to date, using an enhanced analytical framework to integrate de novo and case-control rare variation, identifies 102 risk genes at a false discovery rate of 0.1 or less, consistent with multiple paths to an excitatory-inhibitory imbalance underlying ASD.
Independent optical excitation of distinct neural populations
Nathan C. Klapoetke,Yasunobu Murata,Sung Soo Kim,Stefan R. Pulver,Amanda Birdsey-Benson,Yong Ku Cho,Tania K. Morimoto,Amy S. Chuong,Eric J. Carpenter,Zhijian Tian,Jun Wang,Yinlong Xie,Zhixiang Yan,Yong Zhang,Brian Y. Chow,Barbara Surek,Michael Melkonian,Vivek Jayaraman,Martha Constantine-Paton,Gane Ka-Shu Wong,Edward S. Boyden +20 more
TL;DR: Chronos and Chrimson as mentioned in this paper have been shown to enable two-color activation of neural spiking and downstream synaptic transmission in independent neural populations without detectable cross-talk in mouse brain slice.
Journal ArticleDOI
Visual Areas Exert Feedforward and Feedback Influences through Distinct Frequency Channels
André M. Bastos,André M. Bastos,André M. Bastos,Julien Vezoli,Conrado A. Bosman,Conrado A. Bosman,Jan-Mathijs Schoffelen,Robert Oostenveld,Jarrod R Dowdall,Peter De Weerd,Peter De Weerd,Henry Kennedy,Henry Kennedy,Pascal Fries,Pascal Fries +14 more
TL;DR: It is demonstrated that feedforward and feedback signaling use distinct frequency channels, suggesting that they subserve differential communication requirements.
Journal ArticleDOI
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
Agnes Roczniak-Ferguson,Constance S. Petit,Florian Froehlich,Sharon Qian,Jennifer Ky,Brittany Angarola,Tobias C. Walther,Shawn M. Ferguson +7 more
TL;DR: TFEB is identified as a target of mTOR and a mechanism for matching the transcriptional regulation of genes encoding proteins of autophagosomes and lysosomes to cellular need is suggested.
Journal ArticleDOI
Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo
Jonathan Viventi,Dae-Hyeong Kim,Leif Vigeland,Eric S. Frechette,Justin A. Blanco,Yun-Soung Kim,Andrew E. Avrin,Vineet Tiruvadi,Suk Won Hwang,Ann C. Vanleer,Drausin Wulsin,Kathryn A. Davis,Casey E. Gelber,Larry A. Palmer,Jan Van der Spiegel,Jian Wu,Jianliang Xiao,Yonggang Huang,Diego Contreras,John A. Rogers,Brian Litt +20 more
TL;DR: This system is used to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures, and it is found that seizures may manifest as recurrent spiral waves that propagate in the neocortex.
References
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YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells
Yannick Poitelon,Camila Lopez-Anido,Kathleen K. Catignas,Caterina Berti,Marilena Palmisano,Courtney Williamson,Dominique Ameroso,Kansho Abiko,Yoonchan Hwang,Alex Gregorieff,Jeffrey L. Wrana,Mohammadnabi Asmani,Ruogang Zhao,Fraser J. Sim,Lawrence Wrabetz,John Svaren,Maria Laura Feltri +16 more
TL;DR: Yap and Taz are activated in Schwann cells by mechanical stimuli and regulate Schwann cell proliferation and transcription of basal lamina receptor genes, both necessary for radial sorting of axons and subsequent myelination.
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Sensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.
TL;DR: Robust evidence of disrupted sensory processing in individuals with ASD and FXS is outlined, and in respective animal models, focusing on the auditory sensory domain.
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Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination
Jayshree Samanta,Ethan M. Grund,Hernandez Moura Silva,Juan J. Lafaille,Gord Fishell,James L. Salzer +5 more
TL;DR: Recruitment of endogenous neural stem cells can be mobilized for the repair of demyelinated lesions by inhibiting Gli1, identifying a new therapeutic avenue for the treatment of demYelinating disorders.
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Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1
TL;DR: These findings suggest that a form of long-term visual recognition memory is stored via synaptic plasticity in primary sensory cortex, and suggest that stimulus-selective response potentiation occurred in layer 4 of V1 as OSH developed.
Journal ArticleDOI
Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer
TL;DR: It is found that prostate and breast cancer stem cells secreted vesicles of endosomal origin, calledExosomes showed strong connection between autophagy and exosomes released from CSCs, which may be useful to understand the mechanism of exosome formation, release and function.