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The journal of neuroscience : the official journal of the Society for Neuroscience.
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The article was published on 1981-01-01 and is currently open access. It has received 1737 citations till now.read more
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Journal ArticleDOI
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
F. Kyle Satterstrom,F. Kyle Satterstrom,Jack A. Kosmicki,Jiebiao Wang,Michael S. Breen,Silvia De Rubeis,Joon Yong An,Joon Yong An,Minshi Peng,Ryan Collins,Jakob Grove,Jakob Grove,Lambertus Klei,Christine Stevens,Jennifer Reichert,Maureen Mulhern,Mykyta Artomov,Sherif Gerges,Brooke Sheppard,Xinyi Xu,Aparna Bhaduri,Utku Norman,Harrison Brand,Grace Schwartz,Rachel Nguyen,Elizabeth E. Guerrero,Caroline Dias,Branko Aleksic,Richard Anney,Mafalda Barbosa,Somer L. Bishop,Alfredo Brusco,Jonas Bybjerg-Grauholm,Angel Carracedo,Marcus C.Y. Chan,Andreas G. Chiocchetti,Brian H.Y. Chung,Hilary Coon,Michael L. Cuccaro,Aurora Currò,Bernardo Dalla Bernardina,Ryan N. Doan,Enrico Domenici,Shan Dong,Chiara Fallerini,Montserrat Fernández-Prieto,Giovanni Battista Ferrero,Christine M. Freitag,Menachem Fromer,J. Jay Gargus,Daniel H. Geschwind,Elisa Giorgio,Javier González-Peñas,Stephen J. Guter,Danielle Halpern,Emily Hansen-Kiss,Xin He,Gail E. Herman,Irva Hertz-Picciotto,David M. Hougaard,Christina M. Hultman,Iuliana Ionita-Laza,Suma Jacob,Jesslyn Jamison,Astanand Jugessur,Miia Kaartinen,Gun Peggy Knudsen,Alexander Kolevzon,Itaru Kushima,So Lun Lee,Terho Lehtimäki,Elaine T. Lim,Carla Lintas,W. Ian Lipkin,Diego Lopergolo,Fátima Lopes,Yunin Ludena,Patrícia Maciel,Per Magnus,Behrang Mahjani,Nell Maltman,Dara S. Manoach,Gal Meiri,Idan Menashe,Judith Miller,Nancy J. Minshew,Eduarda Montenegro M. de Souza,Danielle de Paula Moreira,Eric M. Morrow,Ole Mors,Preben Bo Mortensen,Matthew W. Mosconi,Pierandrea Muglia,Benjamin M. Neale,Merete Nordentoft,Norio Ozaki,Aarno Palotie,Mara Parellada,Maria Rita Passos-Bueno,Margaret A. Pericak-Vance,Antonio M. Persico,Isaac N. Pessah,Kaija Puura,Abraham Reichenberg,Alessandra Renieri,Evelise Riberi,Elise B. Robinson,Elise B. Robinson,Kaitlin E. Samocha,Sven Sandin,Sven Sandin,Susan L. Santangelo,Susan L. Santangelo,Gerry Schellenberg,Stephen W. Scherer,Sabine Schlitt,Rebecca J. Schmidt,Lauren M. Schmitt,Isabela Maya Wahys Silva,Tarjinder Singh,Tarjinder Singh,Paige M. Siper,Moyra Smith,Gabriela Soares,Camilla Stoltenberg,Pål Surén,Ezra Susser,John A. Sweeney,Peter Szatmari,Lara Tang,Flora Tassone,Karoline Teufel,Elisabetta Trabetti,Maria del Pilar Trelles,Christopher A. Walsh,Lauren A. Weiss,Thomas Werge,Donna M. Werling,Emilie M. Wigdor,Emilie M. Wigdor,Emma Wilkinson,A. Jeremy Willsey,Timothy W. Yu,Mullin H.C. Yu,Ryan Yuen,Elaine Cristina Zachi,Esben Agerbo,Thomas Damm Als,Vivek Appadurai,Marie Bækvad-Hansen,Rich Belliveau,Alfonso Buil,Caitlin E. Carey,Felecia Cerrato,Kimberly Chambert,Claire Churchhouse,Claire Churchhouse,Søren Dalsgaard,Ditte Demontis,Ashley Dumont,Jacqueline I. Goldstein,Christine Søholm Hansen,Mads E. Hauberg,Mads E. Hauberg,Mads E. Hauberg,Mads V. Hollegaard,Daniel P. Howrigan,Hailiang Huang,Julian Maller,Alicia R. Martin,Joanna Martin,Manuel Mattheisen,Jennifer L. Moran,Jonatan Pallesen,Duncan S. Palmer,Carsten Bøcker Pedersen,Marianne Giørtz Pedersen,Timothy Poterba,Jesper Buchhave Poulsen,Stephan Ripke,Andrew J. Schork,Wesley K. Thompson,Patrick Turley,Raymond K. Walters,Catalina Betancur,Edwin H. Cook,Louise Gallagher,Michael Gill,James S. Sutcliffe,Audrey Thurm,Michael E. Zwick,Anders D. Børglum,Matthew W. State,A. Ercument Cicek,A. Ercument Cicek,Michael E. Talkowski,David J. Cutler,Bernie Devlin,Stephen Sanders,Kathryn Roeder,Mark J. Daly,Joseph D. Buxbaum +201 more
TL;DR: The largest exome sequencing study of autism spectrum disorder (ASD) to date, using an enhanced analytical framework to integrate de novo and case-control rare variation, identifies 102 risk genes at a false discovery rate of 0.1 or less, consistent with multiple paths to an excitatory-inhibitory imbalance underlying ASD.
Independent optical excitation of distinct neural populations
Nathan C. Klapoetke,Yasunobu Murata,Sung Soo Kim,Stefan R. Pulver,Amanda Birdsey-Benson,Yong Ku Cho,Tania K. Morimoto,Amy S. Chuong,Eric J. Carpenter,Zhijian Tian,Jun Wang,Yinlong Xie,Zhixiang Yan,Yong Zhang,Brian Y. Chow,Barbara Surek,Michael Melkonian,Vivek Jayaraman,Martha Constantine-Paton,Gane Ka-Shu Wong,Edward S. Boyden +20 more
TL;DR: Chronos and Chrimson as mentioned in this paper have been shown to enable two-color activation of neural spiking and downstream synaptic transmission in independent neural populations without detectable cross-talk in mouse brain slice.
Journal ArticleDOI
Visual Areas Exert Feedforward and Feedback Influences through Distinct Frequency Channels
André M. Bastos,André M. Bastos,André M. Bastos,Julien Vezoli,Conrado A. Bosman,Conrado A. Bosman,Jan-Mathijs Schoffelen,Robert Oostenveld,Jarrod R Dowdall,Peter De Weerd,Peter De Weerd,Henry Kennedy,Henry Kennedy,Pascal Fries,Pascal Fries +14 more
TL;DR: It is demonstrated that feedforward and feedback signaling use distinct frequency channels, suggesting that they subserve differential communication requirements.
Journal ArticleDOI
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
Agnes Roczniak-Ferguson,Constance S. Petit,Florian Froehlich,Sharon Qian,Jennifer Ky,Brittany Angarola,Tobias C. Walther,Shawn M. Ferguson +7 more
TL;DR: TFEB is identified as a target of mTOR and a mechanism for matching the transcriptional regulation of genes encoding proteins of autophagosomes and lysosomes to cellular need is suggested.
Journal ArticleDOI
Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo
Jonathan Viventi,Dae-Hyeong Kim,Leif Vigeland,Eric S. Frechette,Justin A. Blanco,Yun-Soung Kim,Andrew E. Avrin,Vineet Tiruvadi,Suk Won Hwang,Ann C. Vanleer,Drausin Wulsin,Kathryn A. Davis,Casey E. Gelber,Larry A. Palmer,Jan Van der Spiegel,Jian Wu,Jianliang Xiao,Yonggang Huang,Diego Contreras,John A. Rogers,Brian Litt +20 more
TL;DR: This system is used to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures, and it is found that seizures may manifest as recurrent spiral waves that propagate in the neocortex.
References
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Journal ArticleDOI
Re-evaluating the functional landscape of the cardiovascular system during development
Norio Takada,Madoka Omae,Fumihiko Sagawa,Neil C. Chi,Satsuki Endo,Satoshi Kozawa,Thomas N. Sato +6 more
TL;DR: A comprehensive and body-wide functional landscape of the cardiovascular functions during development may provide clues as to why the cardiovascular system is the first organ to develop.
Journal ArticleDOI
Ameliorative Effects of Different Transcranial Electrical Stimulation Paradigms on the Novel Object Recognition Task in a Rat Model of Alzheimer Disease.
Amir Hossein Zarifkar,Asadollah Zarifkar,Mohammad Nami,Mohammad Nami,Ali Rafati,Hadi Aligholi,Farzaneh Vafaee +6 more
TL;DR: The results of this study showed that the use of multiple sessions of different tES paradigms could improve Aβ-induced memory impairment in the NOR test, and it can be expected that in addition to using tDCS, other stimulatory paradigm may also be considered in the treatment of AD.
Posted ContentDOI
Calcium channel levels at single synapses predict release probability and are upregulated in homeostatic potentiation
Scott J. Gratz,Joseph J. Bruckner,Roberto X. Hernandez,Karam Khateeb,Gregory T. Macleod,Kate M. O'Connor-Giles +5 more
TL;DR: It is proposed that dynamic reorganization of the active zone cytomatrix during short-term plasticity generates new sites for the incorporation of calcium channels to modulate release properties and circuit function.
Journal ArticleDOI
Altered balance control in thoracic adolescent idiopathic scoliosis during obstructed gait
Kuan-Wen Wu,Tung-Wu Lu,Wei-Chun Lee,Wei-Chun Lee,Ya-Ting Ho,Ting-Chun Huang,Jyh-Horng Wang,Ting-Ming Wang +7 more
TL;DR: The results suggest that the thoracic spinal deformity in Lenke 1 AIS affects the whole-body balance control during obstacle-crossing, which should be monitored for signs of increased risk of loss of balance in the management of such patient groups.
Journal ArticleDOI
Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin
Jianying Li,Qihui Wang,Ying Cui,Xueqin Yang,Yan Li,Xiaoyun Zhang,Mengsheng Qiu,Ze Zhang,Zunyi Zhang +8 more
TL;DR: Evidence is provided that Sufu is involved in the genetic network that restricts the posterior expression of Gli2/3/Hand2 and Gremlin/Fgf in limb bud patterning.