The microRNA World: Small Is Mighty
TLDR
The immense potential of small RNAs as controllers of gene networks is just beginning to unfold.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2003-10-01 and is currently open access. It has received 323 citations till now. The article focuses on the topics: Small nucleolar RNA & Argonaute.read more
Citations
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Oncomirs : microRNAs with a role in cancer
TL;DR: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
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Oncomirs — microRNAs with a role in cancer
TL;DR: Evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes.
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The MicroRNA Spectrum in 12 Body Fluids
Jessica A. Weber,David Baxter,Shile Zhang,David Huang,Kuo-How Huang,Ming-Jen Lee,David J. Galas,David J. Galas,Kai Wang +8 more
TL;DR: The changes in miRNA spectra observed in the urine samples from patients with different urothelial conditions demonstrates the potential for using concentrations of specific miRNAs in body fluids as biomarkers for detecting and monitoring various physiopathological conditions.
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An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues
Chang Gong Liu,George A. Calin,Brian Meloon,Nir Gamliel,Cinzia Sevignani,Manuela Ferracin,Calin Dan Dumitru,Masayoshi Shimizu,Simona Zupo,Mariella Dono,Hansjuerg Alder,Florencia Bullrich,Massimo Negrini,Massimo Negrini,Carlo M. Croce +14 more
TL;DR: A recently developed methodology for miRNA gene expression profiling based on the development of a microchip containing oligonucleotides corresponding to 245 miRNAs from human and mouse genomes is described.
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MicroRNA-143 regulates adipocyte differentiation.
Christine Esau,Xiaolin Kang,Eigen R. Peralta,Elaine Hanson,Eric G. Marcusson,Lingamanaidu V. Ravichandran,Yingqing Sun,Seongjoon Koo,Ranjan J. Perera,Ravi Jain,Nicholas M. Dean,Susan M. Freier,C. Frank Bennett,Bridget Lollo,Richard H. Griffey +14 more
TL;DR: It is reported that the combination of expression data and functional assay results identified a role for miR-143 in adipocyte differentiation and may act through target gene ERK5.
References
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Andrew Fire,SiQun Xu,Mary K. Montgomery,Steven A. Kostas,Steven A. Kostas,Samuel E. Driver,Craig C. Mello +6 more
TL;DR: To their surprise, it was found that double-stranded RNA was substantially more effective at producing interference than was either strand individually, arguing against stochiometric interference with endogenous mRNA and suggesting that there could be a catalytic or amplification component in the interference process.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
TL;DR: 21-nucleotide siRNA duplexes provide a new tool for studying gene function in mammalian cells and may eventually be used as gene-specific therapeutics.
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Role for a bidentate ribonuclease in the initiation step of RNA interference
TL;DR: Dicer is a member of the RNase III family of nucleases that specifically cleave double-stranded RNAs, and is evolutionarily conserved in worms, flies, plants, fungi and mammals, and has a distinctive structure, which includes a helicase domain and dualRNase III motifs.
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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
George A. Calin,Calin Dan Dumitru,Masayoshi Shimizu,Roberta Bichi,Simona Zupo,Evan Noch,Hansjuerg Aldler,Sashi Rattan,Michael J. Keating,Kanti R. Rai,Laura Z. Rassenti,Thomas J. Kipps,Massimo Negrini,Florencia Bullrich,Carlo M. Croce +14 more
TL;DR: Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority (≈68%) of CLL cases.