The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease.
Jose Ordovas-Montanes,Seth Rakoff-Nahoum,Seth Rakoff-Nahoum,Siyi Huang,Lorena Riol-Blanco,Olga Barreiro,Ulrich H. von Andrian,Ulrich H. von Andrian +7 more
TLDR
The contribution of the somatosensory system to autoimmune, autoinflammatory, allergic, and infectious processes in barrier tissues is examined and opportunities for therapeutic manipulation of neuro-immune interactions are discussed.About:
This article is published in Trends in Immunology.The article was published on 2015-10-01 and is currently open access. It has received 124 citations till now. The article focuses on the topics: Inflammatory reflex & Nervous system.read more
Citations
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Journal ArticleDOI
The Sleep-Immune Crosstalk in Health and Disease
TL;DR: The induction of a hormonal constellation that supports immune functions is one likely mechanism underlying the immune-supporting effects of sleep, and sleep appears to promote inflammatory homeostasis through effects on several inflammatory mediators, such as cytokines.
Journal ArticleDOI
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch
Landon K. Oetjen,Madison R. Mack,Jing Feng,Timothy M. Whelan,Haixia Niu,Changxiong J. Guo,Sisi Chen,Anna M. Trier,Amy Z. Xu,Shivani V. Tripathi,Jialie Luo,Xiaofei Gao,Lihua Yang,Samantha L. Hamilton,Peter L. Wang,Jonathan R. Brestoff,Richard Brasington,Andras Schaffer,Frank Brombacher,Chyi-Song Hsieh,Robert W. Gereau,Mark J. Miller,Zhou-Feng Chen,Hongzhen Hu,Steve Davidson,Qin Liu,Brian S. Kim +26 more
TL;DR: An evolutionarily conserved paradigm is revealed in which the sensory nervous system employs classical immune signaling pathways to influence mammalian behavior, including chronic itch.
Journal ArticleDOI
Mechanisms and Therapeutic Relevance of Neuro-immune Communication
TL;DR: Mechanisms of peripheral sensory neuronal function in response to immune challenges, the neural regulation of immunity and inflammation, and the therapeutic implications of those mechanistic insights are reviewed.
Journal ArticleDOI
TFOS DEWS II pain and sensation report
Carlos Belmonte,Jason J. Nichols,Stephanie Cox,James A. Brock,Carolyn G. Begley,David A. Bereiter,Darlene A. Dartt,Anat Galor,Anat Galor,Pedram Hamrah,Jason J. Ivanusic,Deborah S. Jacobs,Nancy A. McNamara,Nancy A. McNamara,Mark I. Rosenblatt,Fiona Stapleton,James S. Wolffsohn +16 more
TL;DR: Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect wetness and reflexly maintain basal tear production and blinking rate, thereby evoking dryness sensations and pain.
Journal ArticleDOI
Effect of neuropeptides on production of inflammatory cytokines by human monocytes
TL;DR: The findings identify a potent mechanism for nervous system regulation of host defense responses in inflammation and immunity and since neuropeptides can be released from peripheral nerve endings into surrounding tissues.
References
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Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Lyudmila V. Borovikova,Svetlana Ivanova,Minghuang Zhang,Huan Yang,Galina I. Botchkina,Linda R. Watkins,Haichao Wang,Naji N. Abumrad,John W. Eaton,Kevin J. Tracey +9 more
TL;DR: Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxaemia in rats inhibited TNF synthesis in liver, attenuated peak serum TNF amounts, and prevented the development of shock.
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Cellular and Molecular Mechanisms of Pain
TL;DR: Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain.
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Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
Michael J. Caterina,A. Leffler,Annika B. Malmberg,William J. Martin,Jodie A. Trafton,K. R. Petersen-Zeitz,Martin Koltzenburg,Allan I. Basbaum,David Julius +8 more
TL;DR: Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.
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Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Simón Méndez-Ferrer,Tatyana V. Michurina,Francesca Ferraro,Amin R. Mazloom,Ben D. MacArthur,Ben D. MacArthur,Sergio A. Lira,David T. Scadden,Avi Ma'ayan,Grigori Enikolopov,Paul S. Frenette,Paul S. Frenette +11 more
TL;DR: It is demonstrated that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs.
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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Mehrdad Matloubian,Charles G. Lo,Guy Cinamon,Matthew J. Lesneski,Ying Xu,Volker Brinkmann,Maria L. Allende,Richard L. Proia,Jason G. Cyster +8 more
TL;DR: It is established that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs.
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Isaac M. Chiu,Balthasar A. Heesters,Balthasar A. Heesters,Nader Ghasemlou,Christian A. von Hehn,Fan Zhao,Johnathan V. Tran,Brian J. Wainger,Amanda Strominger,Sriya Muralidharan,Alexander R. Horswill,Juliane Bubeck Wardenburg,Sun Wook Hwang,Sun Wook Hwang,Michael C. Carroll,Clifford J. Woolf +15 more