A
Anna Richardson
Researcher at University of Manchester
Publications - 39
Citations - 8026
Anna Richardson is an academic researcher from University of Manchester. The author has contributed to research in topics: Frontotemporal dementia & Frontotemporal lobar degeneration. The author has an hindex of 23, co-authored 39 publications receiving 7069 citations. Previous affiliations of Anna Richardson include University of Salford & Salford Royal NHS Foundation Trust.
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Journal ArticleDOI
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
Alan E. Renton,Elisa Majounie,Adrian James Waite,Javier Simón-Sánchez,Javier Simón-Sánchez,Sara Rollinson,J. Raphael Gibbs,J. Raphael Gibbs,Jennifer C. Schymick,Hannu Laaksovirta,John C. van Swieten,John C. van Swieten,Liisa Myllykangas,Hannu Kalimo,Anders Paetau,Yevgeniya Abramzon,Anne M. Remes,Alice Kaganovich,Sonja W. Scholz,Sonja W. Scholz,Sonja W. Scholz,Jamie Duckworth,Jinhui Ding,Daniel W. Harmer,Dena G. Hernandez,Dena G. Hernandez,Janel O. Johnson,Janel O. Johnson,Kin Y. Mok,Mina Ryten,Danyah Trabzuni,Rita Guerreiro,Richard W. Orrell,James Neal,Alexandra Murray,J. P. Pearson,Iris E. Jansen,David Sondervan,Harro Seelaar,Derek J. Blake,Kate Young,Nicola Halliwell,Janis Bennion Callister,Greg Toulson,Anna Richardson,Alexander Gerhard,Julie S. Snowden,David M. A. Mann,David Neary,Mike A. Nalls,Terhi Peuralinna,Lilja Jansson,Veli-Matti Isoviita,Anna-Lotta Kaivorinne,Maarit Hölttä-Vuori,Elina Ikonen,Raimo Sulkava,Michael Benatar,Joanne Wuu,Adriano Chiò,Gabriella Restagno,Giuseppe Borghero,Mario Sabatelli,David Heckerman,Ekaterina Rogaeva,Lorne Zinman,Jeffrey D. Rothstein,Michael Sendtner,Carsten Drepper,Evan E. Eichler,Can Alkan,Ziedulla Abdullaev,Svetlana Pack,Amalia Dutra,Evgenia Pak,John Hardy,Andrew B. Singleton,Nigel Williams,Peter Heutink,Stuart Pickering-Brown,Huw R. Morris,Huw R. Morris,Huw R. Morris,Pentti J. Tienari,Bryan J. Traynor,Bryan J. Traynor +85 more
TL;DR: The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common neurodegenerative diseases, and a large hexanucleotide repeat expansion in the first intron of C9ORF72 is shown.
Journal ArticleDOI
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
Matt Baker,Ian R. A. Mackenzie,Stuart Pickering-Brown,Jennifer Gass,Rosa Rademakers,Caroline Lindholm,Julie S. Snowden,Jennifer Adamson,A. Dessa Sadovnick,Sara Rollinson,Ashley Cannon,Emily Dwosh,David Neary,Stacey Melquist,Anna Richardson,Dennis W. Dickson,Zdenek Berger,Jason L. Eriksen,Todd Robinson,Cynthia Zehr,Chad A. Dickey,Richard Crook,Eileen McGowan,David M. A. Mann,Bradley F. Boeve,Howard Feldman,Mike Hutton +26 more
TL;DR: It is demonstrated that in multiple FTD families with significant evidence for linkage to the same region on chromosome 17q21, FTD is caused by mutations in progranulin (PGRN) that are likely to create null alleles and identified mutations in PGRN as a cause of neurodegenerative disease.
Journal ArticleDOI
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations
Julie S. Snowden,Sara Rollinson,Jennifer C. Thompson,Jennifer C. Thompson,Jennifer M. Harris,Jennifer M. Harris,Cheryl L. Stopford,Cheryl L. Stopford,Anna Richardson,Anna Richardson,Matthew Jones,Matthew Jones,Alexander Gerhard,Alexander Gerhard,Yvonne S Davidson,Andrew C Robinson,Linda Gibbons,Quan Hu,Daniel DuPlessis,David Neary,David Neary,David M. A. Mann,Stuart Pickering-Brown +22 more
TL;DR: Mutations in the C9ORF72 gene may be a major cause not only of frontotemporal dementia with motor neuron disease but also of late onset psychosis, and the behavioural characteristics of patients with C9 ORF72 mutations are qualitatively distinct.
Journal ArticleDOI
Frontotemporal dementia and its subtypes: a genome-wide association study
Raffaele Ferrari,Raffaele Ferrari,Dena G. Hernandez,Dena G. Hernandez,Mike A. Nalls,Jonathan D. Rohrer,Adaikalavan Ramasamy,Adaikalavan Ramasamy,John B.J. Kwok,John B.J. Kwok,Carol Dobson-Stone,Carol Dobson-Stone,William S. Brooks,William S. Brooks,Peter R. Schofield,Peter R. Schofield,Glenda M. Halliday,Glenda M. Halliday,John R. Hodges,John R. Hodges,Olivier Piguet,Olivier Piguet,Lauren Bartley,Elizabeth Thompson,Elizabeth Thompson,Eric Haan,Eric Haan,Isabel Hernández,Agustín Ruiz,Mercè Boada,Barbara Borroni,Alessandro Padovani,Carlos Cruchaga,Nigel J. Cairns,Luisa Benussi,Giuliano Binetti,Roberta Ghidoni,Gianluigi Forloni,Daniela Galimberti,Chiara Fenoglio,Maria Serpente,Elio Scarpini,Jordi Clarimón,Alberto Lleó,Rafael Blesa,Maria Landqvist Waldö,Karin Nilsson,Christer Nilsson,Ian R. A. Mackenzie,Ging-Yuek Robin Hsiung,David M. A. Mann,Jordan Grafman,Jordan Grafman,Jordan Grafman,Christopher Morris,Johannes Attems,Timothy D. Griffiths,Ian G. McKeith,Alan J. Thomas,Pietro Pietrini,Edward D. Huey,Eric M. Wassermann,Atik Baborie,Evelyn Jaros,Evelyn Jaros,Michael Tierney,Pau Pastor,Cristina Razquin,Sara Ortega-Cubero,Elena Alonso,Robert Perneczky,Robert Perneczky,Janine Diehl-Schmid,Panagiotis Alexopoulos,Alexander Kurz,Innocenzo Rainero,Elisa Rubino,Lorenzo Pinessi,Ekaterina Rogaeva,Peter St George-Hyslop,Peter St George-Hyslop,Giacomina Rossi,Fabrizio Tagliavini,Giorgio Giaccone,James B. Rowe,James B. Rowe,Johannes C. M. Schlachetzki,Johannes C. M. Schlachetzki,James Uphill,John Collinge,Simon Mead,Adrian Danek,Adrian Danek,Vivianna M. Van Deerlin,Murray Grossman,John Q. Trojanowski,Julie van der Zee,William Deschamps,Tim Van Langenhove,Marc Cruts,Christine Van Broeckhoven,Stefano F. Cappa,Isabelle Le Ber,Didier Hannequin,Véronique Golfier,Martine Vercelletto,Alexis Brice,Benedetta Nacmias,Sandro Sorbi,Silvia Bagnoli,Irene Piaceri,Jørgen E. Nielsen,Jørgen E. Nielsen,Lena E. Hjermind,Lena E. Hjermind,Matthias Riemenschneider,Manuel Mayhaus,Bernd Ibach,Gilles Gasparoni,Sabrina Pichler,Wei Gu,Wei Gu,Martin N. Rossor,Nick C. Fox,Jason D. Warren,Maria Grazia Spillantini,Huw R. Morris,Patrizia Rizzu,Peter Heutink,Julie S. Snowden,Sara Rollinson,Anna Richardson,Alexander Gerhard,Amalia C. Bruni,Raffaele Maletta,Francesca Frangipane,Chiara Cupidi,Livia Bernardi,Maria Anfossi,Maura Gallo,Maria Elena Conidi,Nicoletta Smirne,Rosa Rademakers,Matthew C. Baker,Dennis W. Dickson,Neill R. Graff-Radford,Ronald C. Petersen,David S. Knopman,Keith A. Josephs,Bradley F. Boeve,Joseph E. Parisi,William W. Seeley,Bruce L. Miller,Anna Karydas,Howard J. Rosen,John C. van Swieten,John C. van Swieten,Elise G.P. Dopper,Harro Seelaar,Yolande A.L. Pijnenburg,Philip Scheltens,Giancarlo Logroscino,Rosa Capozzo,Valeria Novelli,Annibale Alessandro Puca,Massimo Franceschi,Alfredo Postiglione,Graziella Milan,Paolo Sorrentino,Mark Kristiansen,Huei-Hsin Chiang,Caroline Graff,Florence Pasquier,Adeline Rollin,Vincent Deramecourt,Florence Lebert,Dimitrios Kapogiannis,Luigi Ferrucci,Stuart Pickering-Brown,Andrew B. Singleton,John Hardy,Parastoo Momeni +181 more
TL;DR: The findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways ( link to 11q14) are potentially involved in FTD.
Journal ArticleDOI
Working memory, attention, and executive function in Alzheimer's disease and frontotemporal dementia.
TL;DR: A comparison of working memory, attention and executive test performance in patients with AD and frontotemporal dementia shows characteristic frontal lobe abnormalities in FTD and temporoparietal change in typical-AD, highlighting the importance of the posterior hemispheres in working memory.