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Carlos Bustamante
Researcher at Stanford University
Publications - 799
Citations - 122303
Carlos Bustamante is an academic researcher from Stanford University. The author has contributed to research in topics: Population & DNA. The author has an hindex of 161, co-authored 770 publications receiving 106053 citations. Previous affiliations of Carlos Bustamante include Lawrence Berkeley National Laboratory & University of California.
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Proceedings ArticleDOI
Imputation-based assessment of next generation rare exome variant arrays
TL;DR: It is found that imputation is more accurate across both the genome and exome for common variant arrays than the next generation array for all allele frequencies, including rare alleles, and accuracy is substantially improved for rare variants when the same population is included in the reference panel.
Journal ArticleDOI
Assignment of structural transitions during mechanical unwrapping of nucleosomes and their disassembly products
César Díaz-Celis,Cristhian Cañari-Chumpitaz,Robert P Sosa,Juan P. Castillo,Meng Zhang,Enze Cheng,A. Chen,Michael Vien,JeongHoon Kim,Bibiana Onoa,Carlos Bustamante +10 more
TL;DR: Combined optical tweezers and single-molecule fluorescence measurements are performed to annotate the specific DNA segments unwrapped during the force transitions observed in mechanical unwrapping of nucleosomes, and the mechanical signatures of subnucleosomal particles: hexasomes and tetrasomes are characterized.
Journal ArticleDOI
Human origins: Shadows of early migrations.
Carlos Bustamante,Brenna M. Henn +1 more
TL;DR: The genome of a female archaic hominin from Denisova Cave in southern Siberia has now been sequenced from DNA extracted from a finger bone and the morphology of a tooth with a mitochondrial genome very similar to that of the finger bone suggests that these hominins are evolutionarily distinct from both Neanderthals and modern humans.
Posted ContentDOI
Network Enhancement: a general method to denoise weighted biological networks
Bo Wang,Armin Pourshafeie,Marinka Zitnik,Junjie Zhu,Carlos Bustamante,Serafim Batzoglou,Jure Leskovec +6 more
TL;DR: Network Enhancement (NE) is proposed, a novel method for improving the signal-to-noise ratio of undirected, weighted networks, and thereby improving the performance of downstream analysis and is used in denoising biological networks for several challenging yet important problems.