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Carlos Bustamante
Researcher at Stanford University
Publications - 799
Citations - 122303
Carlos Bustamante is an academic researcher from Stanford University. The author has contributed to research in topics: Population & DNA. The author has an hindex of 161, co-authored 770 publications receiving 106053 citations. Previous affiliations of Carlos Bustamante include Lawrence Berkeley National Laboratory & University of California.
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Journal ArticleDOI
Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding.
TL;DR: In this paper, the authors compare the folding kinetics of a ribosome-bound, multi-domain calcium-binding protein stalled at different points in translation with the nascent chain as is being synthesized in real-time, via optical tweezers.
Posted ContentDOI
Germline determinants of the somatic mutation landscape in 2,642 cancer genomes
Sebastian M. Waszak,Grace Tiao,Bin Zhu,Tobias Rausch,Francesc Muyas,Bernardo Rodriguez-Martin,Raquel Rabionet,Sergei Yakneen,Geòrgia Escaramís,Yang Li,Natalie Saini,Steven A. Roberts,German Demidov,Esa Pitkänen,Olivier Delaneau,Jose Maria Heredia-Genestar,Joachim Weischenfeldt,Suyash Shringarpure,Jieming Chen,Hidewaki Nakagawa,Ludmil B. Alexandrov,Oliver Drechsel,L. J. Dursi,Ayellet V. Segrè,Erik Garrison,Serap Erkek,Nina Habermann,Lara Urban,Ekta Khurana,Andy Cafferkey,Shuto Hayashi,Seiya Imoto,Lauri A. Aaltonen,Eva G. Alvarez,Adrian Baez-Ortega,Matthew A. Bailey,Mattia Bosio,Alicia L. Bruzos,Ivo Buchhalter,Carlos Bustamante,Claudia Calabrese,Anthony DiBiase,Mark Gerstein,Aliaksei Holik,Xing Hua,Kuan-lin Huang,Ivica Letunic,Leszek J. Klimczak,Roelof Koster,Sushant Kumar,Michael D. McLellan,R. Jay Mashl,Lisa Mirabello,Steven Newhouse,Aparna Prasad,Gunnar Rätsch,Matthias Schlesner,Roland F. Schwarz,Pramod Sharma,Tal Shmaya,Nikos Sidiropoulos,Lei Song,Hana Susak,Tomas Tanskanen,Marta Tojo,David C. Wedge,Mark H. Wright,Ying Wu,Kai Ye,Venkata Yellapantula,Jorge Zamora,Atul J. Butte,Gad Getz,Jared T. Simpson,Li Ding,Tomas Marques-Bonet,Arcadi Navarro,Alvis Brazma,Peter J. Campbell,Stephen J. Chanock,Nilanjan Chatterjee,Oliver Stegle,Reiner Siebert,Stephan Ossowski,Olivier Harismendy,Dmitry A. Gordenin,Jose M. C. Tubio,Francisco M. De La Vega,Douglas F. Easton,Xavier Estivill,Jan O. Korbel,Icgc +91 more
TL;DR: This study highlights the major impact of rare and common germline variants on mutational landscapes in cancer and inferred over a hundred polymorphic L1/LINE elements with somatic retrotransposition activity in cancer.
Journal ArticleDOI
Imputation-Aware Tag SNP Selection To Improve Power for Large-Scale, Multi-ethnic Association Studies
Genevieve L. Wojcik,Christian Fuchsberger,Christian Fuchsberger,Daniel Taliun,Ryan P. Welch,Alicia R. Martin,Suyash Shringarpure,Christopher S. Carlson,Gonçalo R. Abecasis,Hyun Min Kang,Michael Boehnke,Carlos Bustamante,Christopher R. Gignoux,Eimear E. Kenny +13 more
TL;DR: A novel framework to select tag SNPs using the reference panel of 26 populations from Phase 3 of the 1000 Genomes Project, which demonstrates increased imputation accuracy for rare variants and examines array design strategies that contrast multi-ethnic cohorts vs. single populations.
Journal ArticleDOI
Efficient analysis of large datasets and sex bias with ADMIXTURE
TL;DR: Improvements to the ADMIXTURE software are described, allowing users to extract more information from large genomic datasets, and increased power to detect sex-biased admixture in African-American individuals from the 1000 Genomes project is demonstrated.
Journal ArticleDOI
Can estimates of genetic effective population size contribute to fisheries stock assessments
Jennifer R. Ovenden,G. M. Leigh,D. C. Blower,Andrew T. Jones,Andy Moore,Carlos Bustamante,Rik C. Buckworth,Michael B. Bennett,Christine L. Dudgeon +8 more
TL;DR: This work reviews and evaluates a fisheries-independent method of indexing population size; inferring adult abundance from estimates of the genetic effective size of a population (Ne), and shows that declines in Ne track declines in the abundance of model fisheries species.